Results 31 to 40 of about 24,748 (316)

Cerebellar damage with inflammation upregulates oxytocin receptor expression in Bergmann Glia

Molecular Brain
The cerebellum plays an important role in cognitive and social functioning. Childhood damage in the cerebellum increases the risk of autism spectrum disorder. Cerebellar inflammation induces social avoidance in mice.
Ayumu Inutsuka, Aisa Hattori, Masahide Yoshida, Yuki Takayanagi, Tatsushi Onaka   +4 more
doaj   +1 more source

Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains

Nature Communications, 2020
The oxytocin receptor plays an important role in establishing mature neural circuits for social behavior during the early postnatal period. Here, the authors develop digital reference brains for different postnatal ages and provide a quantitative brain ...
Kyra T. Newmaster, Zachary T. Nolan, Uree Chon, Daniel J. Vanselow, Abigael R. Weit, Manal Tabbaa, Shizu Hidema, Katsuhiko Nishimori, Elizabeth A. D. Hammock, Yongsoo Kim   +9 more
doaj   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Moxie begets MOXI: The journey to a novel hypothesis about Mu-opioid and OXytocin system Interactions

Comprehensive Psychoneuroendocrinology
This narrative review summarizes the early life of the author, Khalin E. Nisbett, and highlights the factors that led to her career in research and her development of two novel research hypotheses: the Mu-opioid and OXytocin system Interaction (MOXI ...
Khalin E. Nisbett
doaj   +1 more source

Tph2-/- female mice restore socio-sexual recognition through upregulating ERα and OTR genes in the amygdala. [PDF]

PLoS ONE, 2018
The central 5-hydroxytryptamine system impairs sociosexual behaviors and olfaction preferences in sexually naive mice. However, it remains unknown whether reproductive experiences impart an effect on the sexual olfactory preferences of female mice ...
Ying Huo, Yaohua Zhang, Huifen Guo, Yingjuan Liu, Qi Fang, Jianxu Zhang   +5 more
doaj   +1 more source

Barriers and Breakthroughs in Targeting the Oxytocin System to Treat Alcohol Use Disorder

Frontiers in Psychiatry, 2022
Development of better treatments for alcohol use disorder (AUD) is urgently needed. One promising opportunity for this development is the potential of targeting the oxytocin peptide system.
Andrey E. Ryabinin, Yangmiao Zhang
doaj   +1 more source

Factor XIII Supplementation in Postpartum Hemorrhage: From Biological Rationale to Clinical Implementation

American Journal of Hematology, EarlyView.
ABSTRACT Postpartum hemorrhage (PPH) remains the leading cause of preventable maternal mortality despite standard interventions. Recent fibrinogen trials failed to improve outcomes, prompting interest in coagulation factor XIII (FXIII). FXIII functions as “molecular cement,” cross‐linking fibrin and stabilizing clots.
Jeremy W. Jacobs, Elizabeth A. Abels, Brian D. Adkins, Garrett S. Booth, Victoria Costa, Sheharyar Raza, Michelle Simon, Jennifer S. Woo, Allison P. Wheeler   +8 more
wiley   +1 more source

Oxytocin alleviates liver fibrosis via hepatic macrophages

JHEP Reports
Background & Aims: Previous studies demonstrated oxytocin treatment effectiveness in reducing mortality and reversing liver fibrosis in mice. However, the underlying mechanism remains obscure, given the absence of oxytocin receptor expression in ...
Xiangyu Zhai, Hao Zhang, Zhijia Xia, Mingkun Liu, Gang Du, Zhengchen Jiang, Huaxin Zhou, Dan Luo, Dandan Dou, Jingxin Li, Wei Wang, Xiaosong Li, Bin Jin   +12 more
doaj   +1 more source

Characterization and Expression of Oxytocin and the Oxytocin Receptor

Molecular Genetics and Metabolism, 2000
Oxytocin, a nonapeptide hormone and neurotransmitter, is expressed in a variety of tissues, as are its receptors. In vivo, oxytocin acts as a paracrine and/or autocrine mediator of multiple biological effects. These effects are exerted primarily through interactions with G-protein-coupled oxytocin/vasopressin receptors, which, via G(q) and G(i ...
H, Shojo, Y, Kaneko
openaire   +2 more sources

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source