Results 31 to 40 of about 1,976 (130)

Neonatal Wet Gangrene With Early Auto‐Amputation in a Resource‐Limited Setting With Incomplete Etiologic Workup: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Neonatal limb gangrene with auto‐amputation is rare and often idiopathic. Early recognition, prompt referral, and thorough etiologic workup—despite resource limitations—are critical. Wet gangrene requires broad‐spectrum antibiotics, wound care, and timely surgical amputation to preserve growth plates and allow future prosthesis fitting.
Milki Tufa Feyisa, Beza Eshetu, Tolosa Dibisa, Mulatu Gshaw, Birhanu Tolera, Endalew Dessie Birara, Adugna Lamessa, Tamirat Godebo Woyimo   +7 more
wiley   +1 more source

An Uncommon Case of Ecthyma Gangrenosum in a Three‐Year‐Old Immunocompetent Child

Clinical Case Reports, Volume 14, Issue 6, June 2026.
The necrotic lesions on day 10. ABSTRACT Ecthyma gangrenosum (EG) is a rare cutaneous finding of Pseudomonas aeruginosa sepsis, typically in immunocompromised patients. We present EG with septic shock in a previously healthy three‐year‐old child who presented with rapidly progressing necrotic eschars and severe neutropenia.
Shobha Maharjan, Nipun Shrestha, Dhruba Shrestha   +2 more
wiley   +1 more source

Analysis of the Phenotype and Gene Mutations of Two Families With Combined Mutations of Anticoagulant Protein Genes

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
In these two pedigrees, we identified distinct mutations in the AT and PC genes. Individuals harboring both mutations exhibited a significantly higher incidence of venous thrombosis. ABSTRACT Background AT and PC are key components of the anticoagulant system. Mutations in their encoding genes, SERPINC1 and PROC, can lead to insufficient protein levels
Yueli Guo, Tingting Shan, Wenjieying Zheng, Chun Zhao, Wanzhong Kong, Xiaojing Zou   +5 more
wiley   +1 more source

Protein C Deficiency Caused by a Novel Mutation in the PROC Gene in an Infant with Delayed Onset Purpura Fulminans

Case Reports in Dermatological Medicine, 2017
Protein C is an anticoagulant that is encoded by the PROC gene. Protein C deficiency (PCD) is inherited in an autosomal dominant or recessive pattern.
Mariam S. Al Harbi, Ayman W. El-Hattab
doaj   +1 more source

The use of negative-pressure wound therapy over a cultured epithelial autograft for full-thickness wounds secondary to purpura fulminans in an infant

Archives of Plastic Surgery, 2021
Purpura fulminans is a serious condition that can result in severe morbidity in the pediatric population. Although autologous skin grafts remain the gold standard for the coverage of partial- to full-thickness wounds, they have several limitations in ...
Benjamin Kah Liang Goh, Alvin Wen Choong Chua, Khong Yik Chew, Gavin Chun-Wui Kang, Li-Wei Chiang, Bien-Keem Tan, Savitha Ramachandran   +6 more
doaj   +1 more source

A Retrospective Study of Adult and Pediatric D‐Dimer Tests to Identify Opportunities for Improved Utilization

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 392-401, April 2026.
ABSTRACT Introduction D‐dimers are produced by lysis of cross‐linked fibrin. In children, D‐dimer testing is used to evaluate disseminated intravascular coagulation (DIC) and some inflammatory states, but its use is not validated for screening or ruling out suspected venous thromboembolic events (VTE).
Rabab Al Dawood, Hassan Abu Sabah, Natalie Mathews, James Douketis, Catherine Hayward   +4 more
wiley   +1 more source

Rare presentation of rickettsial infection as purpura fulminans: a case report

Journal of Medical Case Reports, 2018
Background Purpura fulminans is an acute life-threatening disorder characterized by intravascular thrombosis and hemorrhagic infarction of the skin complicated with disseminated intravascular coagulation. It is commonly seen in acute infections following
Chamara Dalugama, Indika Bandara Gawarammana   +1 more
doaj   +1 more source

Fatal meningococcal septicemia without meningeal signs, contribution of the peripheral smear in diagnosis: Report of a case

Indian Journal of Pathology and Microbiology, 2018
Acute meningococcemia is characterized by extensive purpurae consisting of both petechiae and ecchymoses. This condition can be rapidly fatal without treatment due to shock and severe consumptive coagulopathy.
Deepti Mutreja, Nikhil Moorchung, S J Manasa, Jeenu Varghese   +3 more
doaj   +1 more source

Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure

Brain Sciences, 2020
Neisseria meningitidis-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic ...
Meng-Yu Wu, Chien-Sheng Chen, Chih-Yi Tsay, Giou-Teng Yiang, Jian-Yu Ke, Po-Chen Lin   +5 more
doaj   +1 more source

Capnocytophaga canimorsus Septicaemia Presenting With Multiorgan Dysfunction Syndrome (MODS) and Disseminated Intravascular Coagulation (DIC) in an Immunocompetent Individual

Case Reports in Critical Care, Volume 2026, Issue 1, 2026.
We present a rare case of fulminant Capnocytophaga canimorsus septicaemia in a previously well 52‐year‐old immunocompetent woman, following a minor dog‐related forehead abrasion. Despite a recent course of amoxicillin/clavulanate prescribed by her general practitioner, the patient developed profound sepsis characterised by disseminated intravascular ...
Kadison Michel, Prashant Pruthi, Charlie Corke, Lipi Buch   +3 more
wiley   +1 more source