Results 51 to 60 of about 6,242 (170)

Efficacy and Safety of Human Protein C Concentrate in Japanese Patients With Severe Congenital Protein C Deficiency

Pediatrics International, Volume 68, Issue 1, January/December 2026.
ABSTRACT Background Severe congenital protein C deficiency (SCPCD) is a rare disorder associated with life‐threatening thrombotic complications. Protein C concentrate is recommended for both acute and long‐term management of SCPCD. However, no efficacy and safety data in Japanese patients have been reported.
Katsuyoshi Koh, Keiji Nogami, Harumi Kakuda, Yuri Okimoto, Moeko Hino, Chihiro Suzuki, Souhei Terashio, Hitoshi Ueda, Shouichi Ohga   +8 more
wiley   +1 more source

Púrpura fulminans asociada al embarazo

, 2005
 PF is a serious cutaneous purpuric disease, associated with an intravascular disseminated coagulation syndrome. Among its known causes, besides those of thrombophilia, are viral and bacterial infections, mostly Neisseria meningitidis.
Rosa Echavez, Gisela de la, Donado Gómez, Jorge Hernando, González P., Luis G., Toro Escobar, Juan M., Restrepo C., Alvaro H., Vásquez, Martín E., Cadavid Gutiérrez, Carlos A., Saldarriaga Cartagena, Nora E., Bedoya A., Marisol, Quintero Ossa, Alvaro M.   +9 more
core   +1 more source

Capnocytophaga canimorsus Septicaemia Presenting With Multiorgan Dysfunction Syndrome (MODS) and Disseminated Intravascular Coagulation (DIC) in an Immunocompetent Individual

Case Reports in Critical Care, Volume 2026, Issue 1, 2026.
We present a rare case of fulminant Capnocytophaga canimorsus septicaemia in a previously well 52‐year‐old immunocompetent woman, following a minor dog‐related forehead abrasion. Despite a recent course of amoxicillin/clavulanate prescribed by her general practitioner, the patient developed profound sepsis characterised by disseminated intravascular ...
Kadison Michel, Prashant Pruthi, Charlie Corke, Lipi Buch   +3 more
wiley   +1 more source

Use of Double Dose Intravenous Immunoglobulin Therapy in the Treatment of Streptococcal Toxic Shock Syndrome

Case Reports in Critical Care, Volume 2026, Issue 1, 2026.
Streptococcal toxic shock syndrome (STSS) is a life‐threatening condition with increasing incidence and high mortality worldwide. It is characterised by hypotension and multiorgan failure, resultant of invasive group A Streptococcus (GAS) infections. Intravenous immunoglobulin (IVIG) has been proposed as an adjunctive therapy that reduces mortality in ...
Yuning Xue, Alex Yartsev, Lipi Buch
wiley   +1 more source

Current Understanding of Meningitis Pathogens, Immunity Gap, and Future Prevention Strategies in Sri Lanka: A Narrative Review

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Meningitis, an acute and life‐threatening inflammation of the protective membranes covering the brain and spinal cord caused primarily by bacterial, viral, fungal, or parasitic infections, remains a major global health challenge, causing significant morbidity and mortality, particularly among children and vulnerable populations.
Thashmila Heshani, Dilshan Sandaru, Sachindu Madhushara, Sarfaraz Ahmad Ejazi, Bhagya Deepachandi, Kadir Akar   +5 more
wiley   +1 more source

Purpura fulminans: MRSA sepsis compounded by diclofenac

, 2023
Purpura fulminans is a rare, albeit a life-threatening emergency which has been reportedly triggered by infections, congenital disorders of protein C or S deficiencies, as well as drugs.
Ijaz Hussain, Wajieha Saeed, Faria Altaf, Farwa Nasir Khan, Mahym Mansoor   +4 more
core   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1405-1421, December 2025.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Invasive Meningococcal Disease in a Patient With Complement 7 Deficiency

Journal of General and Family Medicine, Volume 26, Issue 6, Page 646-649, November 2025.
ABSTRACT Neisseria meningitidis can cause invasive meningococcal disease (IMD). Individuals with primary complement deficiencies are at a higher risk of developing IMD. However, cases of IMD associated with complement deficiency have rarely been reported in Japan.
Hiroaki Nishioka, Kazuki Maegawa, Shigeo Hara   +2 more
wiley   +1 more source

Esplenectomia na púrpura trombocitopênica imunológica crônica em crianças [PDF]

, 2011
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Otani, Flávia Helena
core  

Necrotizing Fasciitis of Eyelid in Children: A Rare Complication of Varicella Infection

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Necrotizing fasciitis (NF) of the eyelid is an extremely rare but severe complication of varicella zoster virus (VZV) infection in children. We present a case of an 8‐year‐old girl who developed necrotizing fasciitis of the left eyelid following varicella infection.
Govinda Bhandari, Himal Acharya, Richa Paudyal   +2 more
wiley   +1 more source