Results 161 to 170 of about 9,946 (182)

p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways

Bone, 2013
Recent data suggest that several uremic toxins may contribute to the development of bone abnormalities in chronic kidney disease. p-Cresyl sulfate (PCS), the sulfate conjugate of p-cresol, is a protein-bound uremic toxin associated with the progression of chronic kidney disease, cardiovascular risk, and mortality.
Hisae, Tanaka, Yoshiko, Iwasaki, Hideyuki, Yamato, Yoshitaka, Mori, Hirotaka, Komaba, Hiroshi, Watanabe, Toru, Maruyama, Masafumi, Fukagawa   +7 more
openaire   +4 more sources

Dietary protein-fiber ratio associates with circulating levels of indoxyl sulfate and p-cresyl sulfate in chronic kidney disease patients

Nutrition, Metabolism and Cardiovascular Diseases, 2015
Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are uremic toxins derived solely from colonic bacterial fermentation of protein. Dietary fiber may counteract this by limiting proteolytic bacterial fermentation. However, the influence of dietary intake on the generation of IS and PCS has not been adequately explored in chronic kidney disease (CKD).This ...
Rossi, M., Johnson, D. W., Xu, H., Carrero, J. J., Pascoe, E., French, C., Campbell, K. L.   +6 more
openaire   +5 more sources

The Accumulation of Gut Microbiome–derived Indoxyl Sulfate and P-Cresyl Sulfate in Patients With End-stage Renal Disease

Journal of Renal Nutrition, 2022
Indoxyl sulfate (IS) and p-cresyl sulfate (pCS) are two important gut microbiota-generated protein-bound uremic toxins. The present study aims to explore the alterations of serum IS and pCS concentrations, their production, and daily removal in end-stage renal disease (ESRD).A case-controlled study was conducted based on 11 patients with ESRD and 11 ...
Xuechun Lin, Wangqun Liang, Li Li, Qianqian Xiong, Shuiqing He, Jing Zhao, Xiaolei Guo, Siyun Xiang, Piwei Zhang, Hong Wang, Chenjiang Ying, Ying Yao, Xuezhi Zuo   +12 more
openaire   +2 more sources

The Uremic Retention Solute p-Cresyl Sulfate and Markers of Endothelial Damage

American Journal of Kidney Diseases, 2009
Cardiovascular disease is highly prevalent in patients with chronic kidney disease. In hemodialysis patients, the protein-bound uremic retention solute p-cresol is independently associated with cardiovascular disease. The underlying mechanisms have not been elucidated.(1) Prospective observational study of humans and (2) in vitro study in human ...
Björn K I, Meijers, Soetkin, Van Kerckhoven, Kristin, Verbeke, Wim, Dehaen, Yves, Vanrenterghem, Marc F, Hoylaerts, Pieter, Evenepoel   +6 more
openaire   +2 more sources

Interaction between Two Sulfate-Conjugated Uremic Toxins, p-Cresyl Sulfate and Indoxyl Sulfate, during Binding with Human Serum Albumin

Drug Metabolism and Disposition, 2012
Recently, p-cresyl sulfate (PCS) has been identified as a protein-bound uremic toxin. Moreover, the serum-free concentration of PCS, which is associated with its efficacy of hemodialysis, appears to be a good predictor of survival in chronic kidney disease (CKD).
Hiroshi, Watanabe, Tsuyoshi, Noguchi, Yohei, Miyamoto, Daisuke, Kadowaki, Shunsuke, Kotani, Makoto, Nakajima, Shigeyuki, Miyamura, Yu, Ishima, Masaki, Otagiri, Toru, Maruyama   +9 more
openaire   +2 more sources

p -Cresyl sulfate decreases peripheral B cells in mice with adenine-induced renal dysfunction

Toxicology and Applied Pharmacology, 2018
Infection is a major cause of mortality in chronic kidney disease (CKD) patients. Although immune dysfunction is a risk factor for infection in CKD patients, its causes are not fully elucidated. In the present study, we evaluated whether p-cresyl sulfate (pCS), an intestinal bacteria-derived uremic toxin, was involved in immune dysfunction in CKD.
Takahiro, Shiba, Ikuyo, Makino, Takashi, Sasaki, Yuji, Fukuhara, Koji, Kawakami, Ikuo, Kato, Toshihide, Kobayashi   +6 more
openaire   +2 more sources

p-Cresyl sulfate suppresses lipopolysaccharide-induced anti-bacterial immune responses in murine macrophages in vitro

Toxicology Letters, 2016
p-Cresyl sulfate (pCS) is a known uremic toxin that is metabolized from p-cresol produced by intestinal bacteria. Abnormal accumulation of pCS in the blood is a characteristic of chronic kidney disease (CKD). pCS is suggested to cause immune dysfunction and increase the risk of infectious diseases in CKD patients.
Takahiro, Shiba, Ikuyo, Makino, Koji, Kawakami, Ikuo, Kato, Toshihide, Kobayashi, Kimiyuki, Kaneko   +5 more
openaire   +2 more sources

Indoxyl Sulfate and p-Cresyl Sulfate in Chronic Kidney Disease. Could These Toxins Modulate the Antioxidant Nrf2-Keap1 Pathway?

Journal of Renal Nutrition, 2014
Protein-bound uremic toxins (i.e., indoxyl sulfate or p-cresyl sulfate), produced by intestinal bacteria, are accumulated in the plasma of chronic kidney disease (CKD) patients. These toxins interact negatively with biological functions, having potent oxidative stress-inducing effects and a pathological effect on cardiovascular disease. Recent research
Milena Barcza Stockler-Pinto, Denis Fouque, Christophe O. Soulage, Marine Croze, Denise Mafra   +4 more
openaire   +3 more sources

Increased p-cresyl sulfate level is independently associated with poor outcomes in patients with heart failure

Heart and Vessels, 2015
Amino acid-derived metabolites, including protein-bound uremic toxins, may have prognostic value for patients with heart failure (HF). The aim of this study was to investigate whether p-cresyl sulfate (PCS), indoxyl sulfate (IS), and arginine metabolites provided prognostic values in addition to the traditional biomarker, B-type natriuretic peptide ...
Chao-Hung, Wang, Mei-Ling, Cheng, Min-Hui, Liu, Ming-Shi, Shiao, Kuang-Hung, Hsu, Yu-Yen, Huang, Cheng-Cheng, Lin, Jui-Fen, Lin   +7 more
openaire   +2 more sources

In Vivo Kinetics of the Uremic Toxin P‐Cresyl Sulfate in Mice With Variable Renal Function

Therapeutic Apheresis and Dialysis, 2014
AbstractUremic toxins such as p‐cresyl sulfate (PCS) are associated with increased mortality for chronic kidney disease (CKD) patients, but in vivo PCS toxicity studies are limited due to the lack of a standard animal model. To establish such a model, we measured the pharmacokinetics of PCS in mice with variable renal function.
Jingwei, Ni, Wenli, Zhang, Zhengbin, Zhu, Jinzhou, Zhu, Run, Du, Yajun, Jing, Lin, Lu, Ruiyan, Zhang   +7 more
openaire   +2 more sources