Results 151 to 160 of about 507,211 (287)

P-glycoprotein-9-mediated multidrug tolerance in Caenorhabditis elegans. [PDF]

Parasit Vectors
Blancfuney C, Guchen E, Lespine A, Alberich M.   +3 more
europepmc   +1 more source

Analyzing conformational dynamics of single P-glycoprotein transporters by Förster resonance energy transfer using hidden Markov models

, 2013
Nawid Zarrabi, Stefan Ernst, Brandy Verhalen, Stephan Wilkens, Michael Börsch   +4 more
openalex   +1 more source

Relevance of p‐glycoprotein for the enteral absorption of cyclosporin A: in vitro‐in vivo correlation [PDF]

, 1996
Gert Fricker, Jürgen Drewe, Jörg Huwyler, Heike Gutmann, Christoph Beglinger   +4 more
openalex   +1 more source

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

P-glycoprotein and Alzheimer's Disease: Threats and Opportunities. [PDF]

ASN Neuro
Asante JJ, Barger SW.
europepmc   +1 more source

Interspecies comparison of putative ligand binding sites of human, rat and mouse P-glycoprotein

, 2018
Sankalp Jain, Melanie Grandits, Gerhard F. Ecker   +2 more
openalex   +1 more source

Cytochrome P450 3A4 and P-glycoprotein Activity and Assimilation of Tacrolimus in Transplant Patients with Persistent Diarrhea [PDF]

, 2005
Wim Lemahieu, Bart Maes, Kristin Verbeke, Paul Rutgeerts, Karel Geboes, Yves Vanrenterghem   +5 more
openalex   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Targeting the MEK/ERK Pathway to Suppress P-Glycoprotein and Reverse Carfilzomib Resistance in Multiple Myeloma. [PDF]

Int J Mol Sci
Laletina LA, Cherkasova AI, Scherbakova EA, Iamshchikov PS, Koroleva NA, Lushnikova AA, Komissarov AA, Kalitin N, Moiseeva NI.   +8 more
europepmc   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source