Results 161 to 170 of about 21,376,824 (184)
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Bromocriptine Modulates P-Glycoprotein Function
Biochemical and Biophysical Research Communications, 1998 The multidrug resistance (MDR)-associated P-glycoprotein (P-gp) is a membrane transporter which carries, at the expense of MgATP hydrolysis, many amphiphilic molecules, such as the MDR-related cytotoxic drugs vincristine and vinblastine, and the MDR-reversing agents verapamil and progesterone.S, Orlowski, D, Valente, M, Garrigos, E, Ezan +3 moreopenaire +2 more sourcesHerbal Modulation of P‐Glycoprotein
Drug Metabolism Reviews, 2004 P-glycoprotein (Pgp) is a 170 kDa phosphorylated glycoprotein encoded by human MDR1 gene. It is responsible for the systemic disposition of numerous structurally and pharmacologically unrelated lipophilic and amphipathic drugs, carcinogens, toxins, and other xenobiotics in many organs, such as the intestine, liver, kidney, and brain.Zhou, Shufeng, Lim, Lee Yong, Chowbay, Balram +2 moreopenaire +3 more sourcesThe P-glycoprotein multidrug transporter
Essays in Biochemistry, 2011 Pgp (P-glycoprotein) (ABCB1) is an ATP-powered efflux pump which can transport hundreds of structurally unrelated hydrophobic amphipathic compounds, including therapeutic drugs, peptides and lipid-like compounds. This 170 kDa polypeptide plays a crucial physiological role in protecting tissues from toxic xenobiotics and endogenous metabolites, and also openaire +2 more sourcesThe multidrug resistance P-glycoprotein
Current Opinion in Cell Biology, 1993 P-glycoprotein plays an important role in the resistance of cancers to chemotherapy. Thus, an understanding of the mechanism by which it functions, and its 'normal' physiological role, is of clinical relevance as well as intrinsic interest. Considerable progress towards this goal has been made in the last year or so.openaire +2 more sourcesMeasurement of P-glycoprotein Function
2003 The MDR1-encoded P-glycoprotein (Pgp), when overexpressed in tumor cells, confers resistance to many clinically important classes of anticancer drugs. This phenomenon is called multidrug resistance (MDR). The finding that this gene was expressed in many types of human cancers has stimulated many studies into the relevance of this protein for clinical ...openaire +2 more sourcesDisruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.
Cell, 1994 A. Schinkel, J. Smit, O. Tellingen, J. Beijnen, E. Wagenaar, L. V. Deemter, C. A. Mol, M. Valk, E. Robanus-Maandag, H. T. Riele, A. Berns, P. Borst +11 moresemanticscholar +1 more sourceP-glycoprotein
RCSB Protein Data Bank, 2010 R. Hamish McAllister-Williams, Daniel Bertrand, Hans Rollema, Raymond S. Hurst, Linda P. Spear, Tim C. Kirkham, Thomas Steckler, Delphine Capdevielle, Jean-Philippe Boulenger, Delphine Capdevielle, Jean-Philippe Boulenger, Delphine Capdevielle, Jean-Philippe Boulenger, Cyril Höschl, Martine Cador, Ben J. Harrison, Christos Pantelis, Anthony Riley, Steve Kohut, Alex Hofer, Ben J. Harrison, Christos Pantelis, Seithikurippu R. Pandi-Perumal, D. Warren Spence, Shelby Freedman Harris, Michael J. Thorpy, Milton Kramer, Ian Stolerman, Holden D. Brown, Michael Ragozzino, Klaus A. Miczek, Anne Jackson, Sven Ove Ögren, Oliver Stiedl, Paul R. Pentel, Mark LeSage, Victoria L. Harvey, Tony Dickenson, Christine A. Franco, Marc N. Potenza, Gail Winger, Mei-Chuan Ko, James H. Woods, Matthew I. Palmatier, Rick A. Bevins, Stephan G. Anagnostaras, Jennifer R. Sage, Stephanie A. Carmack, Jos Prickaerts, Jos Prickaerts, Jos Prickaerts, Warren H. Meck, Catalin V. Buhushi, Christoph U. Correll, Ian Stolerman, Mohammed Shoaib, Trevor Robbins, Daniel Hoyer, Thomas Steckler, Linda P. Spear, Luzio Tremolizzo, Gessica Sala, Carlo Ferrarese, Seiya Miyamoto, Thomas Steckler, David S. Tait, Verity J. Brown, Richard A. Depue, Tara L. White, Craig A. Erickson, David J. Posey, Kelly Blankenship, Kimberly A. Stigler, Christopher J. McDougle, Craig A. Erickson, David J. Posey, Kelly Blankenship, Kimberly A. Stigler, Christopher J. McDougle, Ian Stolerman, Jean-Michel Scherrmann, S. Stevens Negus, Dana E. Selley, Laura J. Sim-Selley, Christoph Hiemke, Sophie Tambour, John C. Crabbe, Pierre Baumann, Kim Wolff, Christof Baltes, Thomas Mueggler, Markus Rudin, Alan J. Budney, Robert L. Balster, Sharon Walsh, Robert L. Balster, Sharon Walsh, Robert L. Balster, Sharon Walsh, Andrea Bari, Johannes Mosbacher, Paul Willner, Klaus A. Miczek, Trevor Robbins, Wolfgang Fleischhacker, Etienne Sibille, Nicole Edgar, Sabine M. Hölter, John F. Cryan, Michel Le Moal, Marco Leyton, Sara Tomlinson, Glen Baker, Bernard Le Foll, Naheed (Max) Mirza, Tomasz Schneider, Jos Prickaerts, Jos Prickaerts, Robert L. Balster, Sharon Walsh, Yogita Chudasama, Thomas Steckler, Thomas Steckler, Daniel Hoyer, Stan Floresco, Christine A. Franco, Marc Potenza, Fabrizio Benedetti, Peter Riederer, Siegfried Hoyer, Luzio Tremolizzo, Gessica Sala, Carlo Ferrarese, Luzio Tremolizzo, Gessica Sala, Carlo Ferrarese, Lucio Tremolizzo, Gessica Sala, Carlo Ferrarese, Arthur Christopoulos, Gregory D. Stewart, Patrick M. Sexton, Christoph Hiemke, Malcolm Lader, Stefan Leucht, Mark Slifstein, Linda P. Spear, Samuel G. Siris, Susan Jones, Peter Verheart, Per Svenningsson, Per Andrén, Seithikurippu R. Pandi-Perumal, Milton Kramer, Michael J. Thorpy, Shelby Freedman Harris, D. Warren Spence, John Atack, Hilde Lavreysen, Stephen C. Fowler, Harriet de Wit, Britta Hahn, Stephen C. Fowler, Helen Cassaday, Paul Willner, Darren R. Christensen, Warren K. Bickel, Michael Minzenberg, David Baldwin, C. Neill Epperson, C. Neill Epperson, Lawrence Scahill, I. T. Uzbay, Lisiane Bizarro, Bart Ellenbroek, Linda P. Spear, Patrick D. McGorry, Alison R. Yung, Mark A. Geyer, Johannes Mosbacher, Malcolm Lader, Angela Roberts, Celia Morgan, Valerie Curran, Christine A. Franco, Marc Potenza, Celia Morgan, Valerie Curran, Thomas Steckler, Harriet de Wit, Jill B. Becker, Mary Cain, Michael T. Bardo, Thomas Steckler, Trevor Robbins, Theodora Duka, Sam Hutton, C. Neill Epperson, Celia Morgan, Valerie Curran +199 moreopenaire +2 more sourcesMolecular biology of P-glycoprotein
1991 The molecular genetic characterization of MDR human, mouse, and hamster P-glycoprotein genes has identified several elements that may contribute to the diversity in multidrug-resistance phenotype associated with P-glycoprotein expression. First, spontaneous mutations within the MDR genes may alter the relative affinity of P-glycoprotein for certain ...openaire +2 more sources
