Results 71 to 80 of about 21,376,824 (184)
Overview of P-glycoprotein inhibitors: a rational outlook
Brazilian Journal of Pharmaceutical Sciences, 2012 P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP binding cassette (ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It is widely distributed throughout the body and
Kale Mohana Raghava Srivalli +1 more
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Pharmaceutical and Biomedical Research, 2020 Background: Multi drug resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression or overactivation of ATP-binding cassette (ABC) transporters, especially P-glycoprotein (P-gp), in the ...
Morteza Ghandadi
doaj
Marine Natural Products with P-Glycoprotein Inhibitor Properties
Marine Drugs, 2014 P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases.
Dioxelis Lopez, Sergio Martinez-Luis
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The translocation mechanism of P‐glycoprotein
FEBS Letters, 2005 Multidrug transporters are involved in mediating the failure of chemotherapy in treating several serious diseases. The archetypal multidrug transporter P‐glycoprotein (P‐gp) confers resistance to a large number of chemically and functionally unrelated anti‐cancer drugs by mediating efflux from cancer cells.
Callaghan, Richard +2 more
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Slipping past P glycoprotein [PDF]
Science-Business eXchange, 2012 NIH researchers have shown that sphingosine 1-phosphate receptor agonists such as Novartis' Gilenya could transiently reduce P glycoprotein–mediated drug efflux and enhance drug delivery to the brain. The group is evaluating the approach for improving drug delivery to brain tumors.
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P-glycoprotein and its role in drug-drug interactions
, 2014 Efflux transporters such as P-glycoprotein play an important role in drug transport in many organs. In the gut, P-glycoprotein pumps drugs back into the lumen, decreasing their absorption. Drugs which induce P-glycoprotein, such as rifampicin, can reduce
A. Finch, P. Pillans
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The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver*
Journal of Biological Chemistry, 1998 Canalicular secretion of bile salts is a vital function of the vertebrate liver, yet the molecular identity of the involved ATP-dependent carrier protein has not been elucidated.
T. Gerloff +7 more
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Citation: 'P-glycoprotein' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12704 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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Proceedings of the National Academy of Sciences of the United States of America, 2000 Sven Hoffmeyer +10 more
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