Results 221 to 230 of about 25,432,439 (260)

Electroacupuncture reduces cerebral ischemia-induced neuronal damage in the hippocampal CA1 region in rats by inhibiting HMGB1 and p-JNK overexpression

International Journal of Neuroscience, 2023
The cornu ammonis 1 (CA1) region of the hippocampus is a sensitive area that is susceptible to injury caused by cerebral ischemia. High-mobility group box 1 (HMGB1) and phosphorylated c-Jun N-terminal kinase (p-JNK) play important roles in mediating cerebral ischemic injury.To elucidate the mechanism through which electroacupuncture (EA) via the Baihui
Jian, Zhao, Zeyin, Nie, Huachun, Miao, Feng, Wu, Tongjun, Ma   +4 more
openaire   +2 more sources

LS8 cell apoptosis induced by NaF through p-ERK and p-JNK – a mechanism study of dental fluorosis

Acta Odontologica Scandinavica, 2016
To investigate the possible biological mechanism of dental fluorosis at a molecular level.Cultured LS8 were incubated with serum-free medium containing selected concentrations of NaF (0 ∼ 2 mM) for either 24 or 48 h. Subcellular microanatomy was characterized using TEM; meanwhile, selected biomolecules were analysed using various biochemistry ...
Lin, Zhao, Juedan, Li, Jiali, Su, Malcolm L, Snead, Jianping, Ruan   +4 more
openaire   +2 more sources

RAC1-dependent regulation of cholinergically induced lamellar protrusive activity is independent of MAPKinase and attenuated by active p-JNK

NeuroReport, 2002
In SH-SY5Y neuroblastoma cell bodies and growth cones the actin dynamics of cholinergically induced lamellar protrusion is demonstrated by live-imaging. Failure of this reaction in cells over-expressing a dominant negative RAC1-mutant (RAC1(T17N)) confirmed that the actin-dynamics of lamellar protrusion is also, in these cells, RAC1-dependent ...
Angelika, Jung, Harald, Rösner
openaire   +2 more sources

Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma

Life Sciences, 2005
To study the role of c-Jun N-terminal kinase (JNK) and its relation to transcription factor AP-1 and Jun family proteins in hepatocellular carcinoma (HCC) with or without hepatitis B virus (HBV) infection. Immunohistochemical and in situ hybridization techniques were performed for studying phosphorylated JNK (p-JNK), c-Jun, JunB, JunD and AP-1 in 40 ...
Linlang, Guo, Ying, Guo, Sha, Xiao, Xiaobao, Shi   +3 more
openaire   +2 more sources

Electroacupuncture protects against the striatum of ischemia stroke by inhibiting the HMGB1/RAGE/p-JNK signaling pathways

Journal of Chemical Neuroanatomy
The striatum (Str) is injured 20 min after permanent ischemic stroke, leading to neurological deficits. Here, we aimed to explore the effect of electroacupuncture (EA) on ischemic stroke and elucidate the possible underlying mechanism. Rat permanent middle cerebral artery occlusion (pMCAO) model, EA treatment, sham-EA (SEA) treatment, beam-balance test,
Zeyin, Nie, Chenying, Hu, Huachun, Miao, Feng, Wu   +3 more
openaire   +2 more sources

[Effects of electroacupuncture on neurological function and expressions of p-JNK and Beclin-1 in traumatic brain injury rats].

Zhen ci yan jiu = Acupuncture research, 2023
To observe the effect of electroacupuncture (EA) on neurological function, the expressions of phosphorylated c-Jun amino terminal kinase (p-JNK) and Beclin-1 in rats with traumatic brain injury (TBI), so as to explore the underlying mechanism of EA in the treatment of TBI.A total of 64 SD rats were randomly divided into blank, sham, modeling groups ...
Ruo-Chen, Liu, Tao, Wu, Rui-Hui, Wang, Ting, Gu   +3 more
openaire   +1 more source

Protective effect of celastrol in rat cerebral ischemia model: Down-regulating p-JNK, p-c-Jun and NF-κB

Brain Research, 2012
Oxidative stress and inflammatory damage play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Celastrol has been proved to elicit a vanity of biological effects through its anti-oxidant, anti-inflammatory properties in the treatment of Alzheimer's disease, systemic lupus erythematosus, and rheumatoid ...
Yanhua, Li, Dan, He, Xiangjian, Zhang, Zongjie, Liu, Xiaolin, Zhang, Lipeng, Dong, Yinxue, Xing, Chaohui, Wang, Huimin, Qiao, Chunhua, Zhu, Yulin, Chen   +10 more
openaire   +2 more sources

[Expressions of JNK and p-JNK in advanced prostate cancer and their clinical implications].

Zhonghua nan ke xue = National journal of andrology, 2018
To investigate the expressions of JNK and p-JNK in advanced prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their implications.Using immunohistochemistry, we detected the expressions of JNK and p-JNK proteins in 40 cases of paraffin wax-embedded PCa and 21 cases of BPH tissues and analyzed their relationships with advanced PCa and BPH ...
Peng, Zhang, Jian, Han, Lei, Zheng, Ke-Nan, Wang, Lian-Ming, Fan, Hua-Dong, Xie, Shu-Ren, Wang, Tao, Jiang   +7 more
openaire   +1 more source

PP2A Inhibits Cervical Cancer Cell Migration by Dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK Signaling Pathway

Current Medical Science, 2018
Protein phosphatase 2A (PP2A) was reported to play an important role in cancer development; however, the relationship between PP2A and cervical cancer development has yet to be fully understood. The present study aimed to explore the role of PP2A in the development of cervical cancer.
Hong-Yun, Zheng, Fu-Jin, Shen, Yong-Qing, Tong, Yan, Li   +3 more
openaire   +2 more sources

LDL protein nitration: implication for protein unfolding and mitochondrial function by p-JNK-2

2015
An elevated level of LDL cholesterol is associated with the development of atherosclerosis and is also associated with aging. Modification of LDL particle is one of the main contributors to the development of atherosclerosis and is elevated with increasing plasma LDL concentrations.
openaire   +1 more source