Results 1 to 10 of about 123,491 (119)

Multifunctional properties of the transmembrane LPxTG-motif protein derived from Limosilactobacillus reuteri SH-23

open access: yesJournal of Dairy Science, 2023
: The LPxTG-motif protein is an important transmembrane protein with high hydrophilicity and stability, as evidenced by its stress tolerance and adhesion ability.
Qianwen Ye   +7 more
doaj   +1 more source

A Potent Micron Neoantigen Tumor Vaccine GP‐Neoantigen Induces Robust Antitumor Activity in Multiple Tumor Models

open access: yesAdvanced Science, 2022
Therapeutic tumor neoantigen vaccines have been widely studied given their good safety profile and ability to avoid central thymic tolerance. However, targeting antigen‐presenting cells (APCs) and inducing robust neoantigen‐specific cellular immunity ...
Zhe Jing   +9 more
doaj   +1 more source

Mild‐Photothermal Effect Induced High Efficiency Ferroptosis‐Boosted‐Cuproptosis Based on Cu2O@Mn3Cu3O8 Nanozyme

open access: yesAdvanced Science, 2023
A core‐shell‐structured Cu2O@Mn3Cu3O8 (CMCO) nanozyme is constructed to serve as a tumor microenvironment (TME)‐activated copper ionophore to achieve safe and efficient cuproptosis.
Wei Chen   +6 more
doaj   +1 more source

Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I [PDF]

open access: yesPeerJ, 2017
Synaptotagmin I (Syt I) is most abundant in the brain and is involved in multiple cellular processes. Its two C2 domains, C2A and C2B, are the main functional regions.
Tianyao Guo   +6 more
doaj   +2 more sources

Translocation of Structural P Proteins in the Phloem [PDF]

open access: yesThe Plant Cell, 1999
Phloem-specific proteins (P proteins) are particularly useful markers to investigate long-distance trafficking of macromolecules in plants. In this study, genus-specific molecular probes were used in combination with intergeneric grafts to reveal the presence of a pool of translocatable P protein subunits.
Golecki, B., Schulz, A., Thompson, G. A.
openaire   +3 more sources

Nanozyme for tumor therapy: Surface modification matters

open access: yesExploration, 2021
As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease of production and modification, paving the way for its biomedical ...
Guoheng Tang   +4 more
doaj   +1 more source

Poroptosis: A form of cell death depending on plasma membrane nanopores formation

open access: yesiScience, 2022
Summary: Immunogenic cell death (ICD) in malignant cells can decrease tumor burden and activate antitumor immune response to obtain lasting antitumor immunity, leading to the elimination of distant metastases and prevention of recurrence. Here, we reveal
Hao Li   +9 more
doaj   +1 more source

Tuberculosis: Past, present and future of the treatment and drug discovery research

open access: yesCurrent Research in Pharmacology and Drug Discovery, 2021
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Despite decades of research driving advancements in drug development and discovery against TB, it still leads among the causes of deaths due to infectious ...
Ameya D. Bendre   +2 more
doaj   +1 more source

Large Oncosome‐Loaded VAPA Promotes Bone‐Tropic Metastasis of Hepatocellular Carcinoma Via Formation of Osteoclastic Pre‐Metastatic Niche

open access: yesAdvanced Science, 2022
Tumor‐derived extracellular vesicles (EVs) function as critical mediators in selective modulation of the microenvironment of distant organs to generate a pre‐metastatic niche that facilitates organotropic metastasis.
Shuxia Zhang   +16 more
doaj   +1 more source

Anti-inflammation and gut microbiota regulation properties of fatty acids derived from fermented milk in mice with dextran sulfate sodium-induced colitis

open access: yesJournal of Dairy Science, 2022
: The by-products of milk fermentation by lactic acid bacteria provide potential health benefits to the balance of host intestinal microflora. In this study, the anti-inflammatory properties of fatty acids from monoculture-strain (Lactiplantibacillus ...
Lifeng Lao   +7 more
doaj   +1 more source

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