Results 21 to 30 of about 30,659,002 (304)
Communications Biology, 2021 George, Assaiya et al. develop a deep learning tool, CASSPER, that automates the detection of protein particles in transmission microscope images. This algorithm uses semantic segmentation and visually prepared training samples to capture the differences
Blesson George +7 more
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Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]
, 2018 Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias +5 more
core +2 more sources
Combined Raman Spectroscopy and Digital Holographic Microscopy for Sperm Cell Quality Analysis
Journal of Spectroscopy, 2017 The diagnosis of male infertility is vastly complex. To date, morphology, motility, and concentration have been used as key parameters to establish the sperm normality and achieve pregnancy both in natural and in assisted fecundation.
A. De Angelis +5 more
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Journal of General Virology, 2020 Peptide-based inhibitors hold promising potential in the development of antiviral therapy. Here, we investigated the antiviral potential of fragmented viral proteins derived from ribonucleoprotein (RNP) components of the human respiratory syncytial virus (HRSV).
Koyu Hara +7 more
openaire +3 more sources
Crystals, 2019 Interleukin 17A (IL-17A) is a proinflammatory cytokine produced by Th17 cells. Antibody BCD-085 (netakimab) against human IL-17A is one of the new inhibitors of this cytokine.
Olga Kostareva +7 more
doaj +1 more source
Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]
, 2007 An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core +1 more source
Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp. [PDF]
, 2012 The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp).
Rüdiger, Stefan G. D. +10 more
core +3 more sources
Label-Free Imaging and Biochemical Characterization of Bovine Sperm Cells
Biosensors, 2015 A full label-free morphological and biochemical characterization is desirable to select spermatozoa during preparation for artificial insemination. In order to study these fundamental parameters, we take advantage of two attractive techniques: digital ...
Maria Antonietta Ferrara +6 more
doaj +1 more source
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer
Cancer Communications, 2022 With the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction between long non‐coding RNAs (lncRNAs) and RBPs has also received increasing attention.
Zi‐Ting Yao +6 more
doaj +1 more source
Virology, 1996 Previously we showed that the Sendai virus P protein (568 aa) in virus-infected cells and in virions was primarily and constitutively phosphorylated on serine(s) in a single tryptic phosphopeptide TP1. By two-dimensional thin-layer electrophoresis and chromatography analysis of tryptic phosphopeptides of several deletion and point mutants of the P ...
BYRAPPA, SRIDHAR +2 more
openaire +2 more sources