Results 11 to 20 of about 24,345,005 (317)

USP7 promotes non‐small‐cell lung cancer cell glycolysis and survival by stabilizing and activating c‐Abl

Clinical and Translational Medicine, 2023
Background Abelson tyrosine kinase (c‐Abl) is frequently mutated and highly expressed, and promotes non‐small‐cell lung cancer (NSCLC) survival, metastasis and tumorigenesis.
Yuanming He, Shuoyi Jiang, Yueya Zhong, Xiaoge Wang, Yaoli Cui, Jingpei Liang, Yuening Sun, Zhigang Zhu, Zhenqian Huang, Xinliang Mao   +9 more
doaj   +1 more source

Anti-inflammation and gut microbiota regulation properties of fatty acids derived from fermented milk in mice with dextran sulfate sodium-induced colitis

Journal of Dairy Science, 2022
: The by-products of milk fermentation by lactic acid bacteria provide potential health benefits to the balance of host intestinal microflora. In this study, the anti-inflammatory properties of fatty acids from monoculture-strain (Lactiplantibacillus ...
Lifeng Lao, Guo Yang, Ao Zhang, Lianliang Liu, Yuxing Guo, Liwei Lian, Daodong Pan, Zhen Wu   +7 more
doaj   +1 more source

Fluorescence Spectroscopy Approaches for the Development of a Real-Time Organophosphate Detection System Using an Enzymatic Sensor

Sensors, 2015
Organophosphates are organic substances that contain a phosphoryl or a thiophosphoryl bond. They are mainly used around the world as pesticides, but can also be used as chemical warfare agents. Their detection is normally entrusted to techniques like GC-
Paola Carullo, Giovanni Paolo Cetrangolo, Luigi Mandrich, Giuseppe Manco, Ferdinando Febbraio   +4 more
doaj   +1 more source

Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V

Channels, 2022
JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus oocytes but had no effects on Kv1 ...
Xu Dehong, Wu Wenmei, Hong Siqin, Zeng Peng, Wang Xianchun, Zeng Xiongzhi   +5 more
doaj   +1 more source

CASSPER is a semantic segmentation-based particle picking algorithm for single-particle cryo-electron microscopy

Communications Biology, 2021
George, Assaiya et al. develop a deep learning tool, CASSPER, that automates the detection of protein particles in transmission microscope images. This algorithm uses semantic segmentation and visually prepared training samples to capture the differences
Blesson George, Anshul Assaiya, Robin J. Roy, Ajit Kembhavi, Radha Chauhan, Geetha Paul, Janesh Kumar, Ninan S. Philip   +7 more
doaj   +1 more source

Combined Raman Spectroscopy and Digital Holographic Microscopy for Sperm Cell Quality Analysis

Journal of Spectroscopy, 2017
The diagnosis of male infertility is vastly complex. To date, morphology, motility, and concentration have been used as key parameters to establish the sperm normality and achieve pregnancy both in natural and in assisted fecundation.
A. De Angelis, S. Managò, M. A. Ferrara, M. Napolitano, G. Coppola, A. C. De Luca   +5 more
doaj   +1 more source

Fab Fragment of V_HH-Based Antibody Netakimab: Crystal Structure and Modeling Interaction with Cytokine IL-17A

Crystals, 2019
Interleukin 17A (IL-17A) is a proinflammatory cytokine produced by Th17 cells. Antibody BCD-085 (netakimab) against human IL-17A is one of the new inhibitors of this cytokine.
Olga Kostareva, Ilya Kolyadenko, Andrey Ulitin, Victoria Ekimova, Stanislav Evdokimov, Maria Garber, Svetlana Tishchenko, Azat Gabdulkhakov   +7 more
doaj   +1 more source

Anti-ribosomal P protein antibodies

Autoimmunity, 2005
Anti-ribosomal P protein antibodies (Abs) recognize three specific ribosomal proteins located in the large ribosome's subunit. The term anti-ribosomal P protein Abs, often shortened in anti-P Abs, is due to the fact that these three proteins, P0, P1 and P2, of 38, 19 and 17 Kd molecular weight, respectively, are phosphorylated.
GERLI, Roberto, Caponi L.
openaire   +4 more sources

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]

, 2018
Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias, Sub Cellular Protein Chemistry, Kityk, R., Rüdiger, S.G.D., Morán Luengo, T., Cellular Protein Chemistry   +5 more
core   +1 more source

A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein

Journal of General Virology, 2020
Peptide-based inhibitors hold promising potential in the development of antiviral therapy. Here, we investigated the antiviral potential of fragmented viral proteins derived from ribonucleoprotein (RNP) components of the human respiratory syncytial virus (HRSV).
Koyu Hara, Kenichiro Yaita, Pattara Khamrin, Kattareeya Kumthip, Takahito Kashiwagi, Jean-François Eléouët, Marie-Anne Rameix-Welti, Hiroshi Watanabe   +7 more
openaire   +3 more sources