Results 11 to 20 of about 3,942,196 (308)

USP7 promotes non‐small‐cell lung cancer cell glycolysis and survival by stabilizing and activating c‐Abl

Clinical and Translational Medicine, 2023
Background Abelson tyrosine kinase (c‐Abl) is frequently mutated and highly expressed, and promotes non‐small‐cell lung cancer (NSCLC) survival, metastasis and tumorigenesis.
Yuanming He, Shuoyi Jiang, Yueya Zhong, Xiaoge Wang, Yaoli Cui, Jingpei Liang, Yuening Sun, Zhigang Zhu, Zhenqian Huang, Xinliang Mao   +9 more
doaj   +1 more source

Anti-inflammation and gut microbiota regulation properties of fatty acids derived from fermented milk in mice with dextran sulfate sodium-induced colitis

Journal of Dairy Science, 2022
: The by-products of milk fermentation by lactic acid bacteria provide potential health benefits to the balance of host intestinal microflora. In this study, the anti-inflammatory properties of fatty acids from monoculture-strain (Lactiplantibacillus ...
Lifeng Lao, Guo Yang, Ao Zhang, Lianliang Liu, Yuxing Guo, Liwei Lian, Daodong Pan, Zhen Wu   +7 more
doaj   +1 more source

A functional RNase P protein subunit of bacterial origin in some eukaryotes [PDF]

, 2011
RNase P catalyzes 5′-maturation of tRNAs. While bacterial RNase P comprises an RNA catalyst and a protein cofactor, the eukaryotic (nuclear) variant contains an RNA and up to ten proteins, all unrelated to the bacterial protein.
Bernal Bayard, Pilar, Gopalan, Venkat, Lai, Lien B., Lai, Stella M., Mohannath, Gireesha, Vioque Peña, Agustín   +5 more
core   +1 more source

Fluorescence Spectroscopy Approaches for the Development of a Real-Time Organophosphate Detection System Using an Enzymatic Sensor

Sensors, 2015
Organophosphates are organic substances that contain a phosphoryl or a thiophosphoryl bond. They are mainly used around the world as pesticides, but can also be used as chemical warfare agents. Their detection is normally entrusted to techniques like GC-
Paola Carullo, Giovanni Paolo Cetrangolo, Luigi Mandrich, Giuseppe Manco, Ferdinando Febbraio   +4 more
doaj   +1 more source

Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V

Channels, 2022
JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus oocytes but had no effects on Kv1 ...
Xu Dehong, Wu Wenmei, Hong Siqin, Zeng Peng, Wang Xianchun, Zeng Xiongzhi   +5 more
doaj   +1 more source

Structural Analysis of Human Respiratory Syncytial Virus P Protein: Identification of Intrinsically Disordered Domains [PDF]

, 2014
Human Respiratory Syncytial Virus P protein plus the viral RNA, N and L viral proteins, constitute the viral replication complex. In this report we describe that HRSV P protein has putative intrinsically disordered domains predicted by in silico methods.
Asara, John M., Guerrero, Manuel C., Libermann, Towia A., Simabuco, Fernando M., Ventura, Armando M., Zerbini, Luiz F.   +5 more
core   +1 more source

Production and purification of the phosphoprotein of Nipah virus in Escherichia coli for use in diagnostic assays. [PDF]

, 2011
Nipah Virus (NiV) is an emerging zoonotic paramyxovirus that can be fatal in humans and various types of animals. The phospho (P) protein of NiV plays an important role in RNA synthesis, replication, and genome synthesis.
Salvamani, Shamala, Tan, Wen Siang, Tey, Beng Ti, Wen, Cheng Ng   +3 more
core   +1 more source

Algebraic shortcuts for leave-one-out cross-validation in supervised network inference [PDF]

, 2020
Supervised machine learning techniques have traditionally been very successful at reconstructing biological networks, such as protein-ligand interaction, protein-protein interaction and gene regulatory networks.
Airola, Antti, De Baets, Bernard, Pahikkala, Tapio, Stock, Michiel, Waegeman, Willem   +4 more
core   +1 more source

CASSPER is a semantic segmentation-based particle picking algorithm for single-particle cryo-electron microscopy

Communications Biology, 2021
George, Assaiya et al. develop a deep learning tool, CASSPER, that automates the detection of protein particles in transmission microscope images. This algorithm uses semantic segmentation and visually prepared training samples to capture the differences
Blesson George, Anshul Assaiya, Robin J. Roy, Ajit Kembhavi, Radha Chauhan, Geetha Paul, Janesh Kumar, Ninan S. Philip   +7 more
doaj   +1 more source

The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1. [PDF]

J Virol, 2016
Spring viremia of carp virus (SVCV) is an efficient pathogen causing high mortality in the common carp. Fish interferon (IFN) is a powerful cytokine enabling host cells to establish an antiviral response; therefore, the strategies that SVCV uses to avoid
Li S, Lu LF, Wang ZX, Lu XB, Chen DD, Nie P, Zhang YA.   +6 more
europepmc   +3 more sources