Results 61 to 70 of about 30,659,002 (304)
An artificial immune system for clustering amino acids in the context of protein function classification [PDF]
, 2009 This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon +5 more
core +1 more source
Marine Drugs, 2016 Microorganisms living in extreme environments represent a huge reservoir of novel antimicrobial compounds and possibly of novel chemical families.
Pietro Tedesco +10 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga +3 more
wiley +1 more source
Analysis of Disulfide Bond Formation [PDF]
, 2017 In this unit, protocols are provided for detection of disulfide bond formation in cultures of intact cells and in an in vitro translation system containing isolated microsomes or semi-permeabilized cells.
Sub Cellular Protein Chemistry +9 more
core +2 more sources
Antitumor Effect of Anti‐c‐Myc Aptamer‐Based PROTAC for Degradation of the c‐Myc Protein
Advanced ScienceTargeting “undruggable” targets with intrinsically disordered structures is of great significance for the treatment of disease. The transcription factor c‐Myc controls global gene expression and is an attractive therapeutic target for multiple types of ...
Yuchun Wang +15 more
doaj +1 more source
Cornichons: Evolution, AMPA receptor modulation, and emerging roles beyond the nervous system
Brain DisordersCornichons are auxiliary proteins that regulate the functions of AMPA receptors (AMPARs), which mediate fast excitatory transmission in the central nervous system.
Pratibha Bharti +3 more
doaj +1 more source
Clinical and serologic associations of the antiribosomal P protein antibody [PDF]
Arthritis & Rheumatism, 1986 AbstractAntibodies to the ribosomal P proteins (anti‐P) were detected, by Western blot analysis, in the sera of 20 of 114 patients with various autoimmune disorders. Eighty‐five percent of the patients with anti‐P had systemic lupus erythematosus (SLE). Of 93 randomly selected patients, the frequency of anti‐P was 7 of 59 SLE patients (12%) and 0 of 34
E, Bonfa, K B, Elkon
openaire +2 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source
Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]
, 2009 To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
core +1 more source
The P body protein Dcp1a is hyper-phosphorylated during mitosis. [PDF]
PLoS ONE, 2013 Processing bodies (PBs) are non-membranous cytoplasmic structures found in all eukaryotes. Many of their components such as the Dcp1 and Dcp2 proteins are highly conserved.
Adva Aizer +3 more
doaj +1 more source