Results 81 to 90 of about 3,904,130 (286)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science
Castration‐resistant prostate cancer (CRPC) remains the leading cause of mortality among prostate cancer patients. While second‐generation androgen receptor (AR) pathway‐targeted therapies, such as Abiraterone, have significantly improved survival ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Synaptophysin and synaptoporin expression in the developing rat olfactory system [PDF]

, 1993
The expressions of two closely related synaptic vesicle antigens synaptophysin and synaptoporin were examined in the olfactory system of the adult rat and during pre- and postnatal development.
Bayer, Bergmann, Betz, Bixby, Breipohl, Brunjes, Elferink, Farbman, Farbman, Fletcher, Geppert, Gesteland, Graziadei, Halász, Halász, Hinds, Hsu, Huttner, Jahn, Jahn, Knaus, Kosaka, Lahr, Lahr, Leube, Mandell, Marchand, Margolis, Marquèze-Pouey, Matteoli, McLean, Navone, Ovtscharoff, Pedersen, Rehn, Schwob, Schwob, Shipley, Smotherman, Specht, Specht, Südhof, Thomas, Thomas, Tixier-Vidal, Trimble, Van Lookeren Campagne, Verhaagen, Wendland, Wiedenmann, Zhong   +50 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]

, 2017
Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Alexis M. Kalergis, Alexis M. Kalergis, Claudia A. Riedel, Emma Rey-Jurado, Gisela Canedo-Marroquín, Juan M. Saavedra, Margarita K. Lay, Margarita K. Lay, Orlando Acevedo-Acevedo, Susan M. Bueno   +9 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The nutritive value of lupins in sole cropping systems and mixed intercropping with spring cereals for grain production [PDF]

, 2008
In total 572 experimental plots were established at two sites during three years with different grain legume species, such as lupins, field beans and peas as well as mixed intercropping of different legumes or legumes with spring cereals for grain ...
Aulrich, Karen, Berk, Andreas, Bramm, Andreas, Böhm, Herwart, Rühl, Gerhard   +4 more
core  

Regions on Nucleocapsid Protein of Newcastle Disease Virus that Interact with its Phosphoprotein [PDF]

, 2004
Summary. The nucloecapsid (NP) and phosphor-(P) proteins of paramyxoviruses are involved in transcription and replication of the viral genome. An in vitro protein binding assay was used to investigate the regions on NP protein that interact with the P ...
Chiew, Ling Kho, Tan, Wen Siang, Tey, Beng Ti, Yusoff, Khatijah   +3 more
core   +1 more source

Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp.

Marine Drugs, 2018
The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity-guided fractionation scheme was applied on the Gram-negative bacterium Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized culture chip technique.
Giuseppina Chianese, Fortunato Palma Esposito, Delphine Parrot, Colin Ingham, Donatella de Pascale, Deniz Tasdemir   +5 more
doaj   +1 more source