Results 221 to 230 of about 80,651 (264)

P-selectin in arterial thrombosis

Zeitschrift f�r Kardiologie, 2004
P-selectin is a transmembrane protein present in the alpha granules of platelets and the Weibel-Palade bodies of endothelial cells. Following activation, it is rapidly translocated to the cell surface. P-selectin expression in platelets has been shown to be elevated in disorders associated with arterial thrombosis such as coronary artery disease, acute
M, Merten, P, Thiagarajan
openaire   +2 more sources

P-Selectin Antagonism in Inflammatory Disease

Current Pharmaceutical Design, 2010
Inflammation plays a fundamental role in many chronic diseases, including atherosclerosis associated cardiovascular disease. Adhesion of immune cells plays a critical role in the inflammatory response and indeed the pathophysiology of inflammatory related diseases.
Kevin J, Woollard, Jaye, Chin-Dusting
openaire   +2 more sources

Targeting P-selectin in acute pancreatitis

Expert Opinion on Therapeutic Targets, 2010
Acute pancreatitis (AP) is a multifactorial disorder not fully understood yet. In particular, the pathogenetic pathways promoting a severe life-threatening course of AP are the subject of ongoing investigations. P-selectin has been shown to play a central role in the complex pathophysiology in AP as well as various other inflammatory conditions.P ...
Thilo, Hackert, Markus W, Büchler, Jens, Werner   +2 more
openaire   +2 more sources

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo

Blood, 2000
Selectin-dependent rolling is the earliest observable event in the recruitment of leukocytes to inflamed tissues. Several glycoproteins decorated with sialic acid, fucose, and/or sulfate have been shown to bind the selectins. The best-characterized selectin ligand is P-selectin glycoprotein-1 (PSGL-1) that supports P-selectin– dependent rolling in ...
K E, Norman, A G, Katopodis, G, Thoma, F, Kolbinger, A E, Hicks, M J, Cotter, A G, Pockley, P G, Hellewell   +7 more
openaire   +2 more sources

Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G

Blood, 2001
In the inflammatory response, leukocyte rolling before adhesion and transmigration through the blood vessel wall is mediated by specific cell surface adhesion receptors. Neutrophil rolling involves the interaction of P-selectin expressed on activated endothelium and its counter-receptor on neutrophils, P-selectin glycoprotein ligand-1 (PSGL-1).
Gardiner, Elizabeth E., De Luca, Mariagrazia, McNally, Tracy, Michelson, Alan D., Andrews, Robert K., Berndt, Michael C.   +5 more
openaire   +3 more sources

Platelet surface p‐selectin, platelet–granulocyte heterotypic aggregates, and plasma‐soluble p‐selectin during plateletpheresis

Transfusion, 1999
BACKGROUND: Plateletpheresis components have been shown to contain p‐selectin‐positive platelets after collection and storage. P‐selectin mediates binding of activated platelets to granulocytes and monocytes. This study was undertaken to assess platelet activation, granulocyte activation, platelet–granulocyte heterotypic aggregate formation, and the ...
Barnard, Marc R., Macgregor, Hollace, Mercier, R., Ragno, G., Pivacek, L. E., Hechtman, Herbert B., Michelson, Alan D., Valeri, C. Robert   +7 more
openaire   +3 more sources

Interaction between Soluble P-Selectin and Soluble P-Selectin Glycoprotein Ligand 1:  Equilibrium Binding Analysis

Biochemistry, 1998
Leukocyte rolling in the vasculature is mediated by the interaction of endothelial P-selectin and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1). Since cell-cell interaction mediated by P-selectin and PSGL-1 is cooperative and complex, we have developed a model system to examine the binding of P-selectin to PSGL-1 in a soluble system.
K, Croce, S J, Freedman, B C, Furie, B, Furie   +3 more
openaire   +2 more sources

Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke

Thrombosis and Haemostasis, 2004
SummaryThe pathophysiology of ischaemic stroke involves the platelet. In this study, we hypothesised that abnormalities in platelet morphology, as well as soluble (sPsel) and total platelet P-selectin (pPsel) levels would be present in patients presenting with an acute ischaemic stroke, and that these changes would improve at ≥ 3 months’ follow-up.
Sunil K, Nadar, Gregory Y H, Lip, Andrew D, Blann   +2 more
openaire   +2 more sources

P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised

Scandinavian Journal of Clinical and Laboratory Investigation, 2013
Knowledge concerning the neurobiological importance of platelets in Alzheimer's disease (AD) is sparse. P-selectin, which is located together with β-amyloid precursor proteins in platelet α-granules, is also found in endothelial cells. Upon activation, P-selectin is relocated to cell surfaces where it acts as a receptor.
Petter, Järemo, Micha, Milovanovic, Caroline, Buller, Staffan, Nilsson, Bengt, Winblad   +4 more
openaire   +2 more sources

[Expression and identification of recombinant P-selectin and P-selectin glycoprotein ligand-1].

Sheng li xue bao : [Acta physiologica Sinica], 2015
P-selectin, one of the membrane proteins, expresses on platelet and endothelia and interacts with P-selectin glycoprotein ligand-1 (PSGL-1) on leukocyte membrane. This interaction mediates leukocytes rolling on endothelial membrane and then induces leukocyte recruitment to the site of infection or tissue injury. In the present study, we constructed the
Xin-Hui, Pei, Zhi-Xin, Lin, Jian-Guo, Geng   +2 more
openaire   +1 more source