Results 201 to 210 of about 54,143 (245)

The roles of P-selectin in cancer cachexia

Medical Oncology, 2023
P-selectin, a cell adhesion molecule of the selectin family, is expressed on the surface of activated endothelial cells (ECs) and platelets. Binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) supports the leukocytes capture and rolling on stimulated ECs and increases the aggregation of leukocytes and activated platelets. Cancer cachexia
Tingting Ling, Jing Liu, Liang Dong, Ju Liu   +3 more
openaire   +2 more sources

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo

Blood, 2000
Selectin-dependent rolling is the earliest observable event in the recruitment of leukocytes to inflamed tissues. Several glycoproteins decorated with sialic acid, fucose, and/or sulfate have been shown to bind the selectins. The best-characterized selectin ligand is P-selectin glycoprotein-1 (PSGL-1) that supports P-selectin– dependent rolling in ...
K E, Norman, A G, Katopodis, G, Thoma, F, Kolbinger, A E, Hicks, M J, Cotter, A G, Pockley, P G, Hellewell   +7 more
openaire   +2 more sources

Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G

Blood, 2001
In the inflammatory response, leukocyte rolling before adhesion and transmigration through the blood vessel wall is mediated by specific cell surface adhesion receptors. Neutrophil rolling involves the interaction of P-selectin expressed on activated endothelium and its counter-receptor on neutrophils, P-selectin glycoprotein ligand-1 (PSGL-1).
Gardiner, Elizabeth E., De Luca, Mariagrazia, McNally, Tracy, Michelson, Alan D., Andrews, Robert K., Berndt, Michael C.   +5 more
openaire   +3 more sources

Effects of desmopressin on circulating P‐selectin

British Journal of Haematology, 1996
Von Willebrand factor (VWF) and P‐selectin share an identical intracellular storage compartment and transport to the cell surface. We induced degranulation of the Weibel‐Palade bodies and measured circulating (c)P‐selectin in plasma to test whether soluble P‐selectin is present in the Weibel‐Palade bodies, or if P‐selectin bound to the cell membrane of
B, Jilma, H G, Eichler, B, Vondrovec, H, Breiteneder, P A, Kyrle, E, Kitzweger, S, Kapiotis, W, Speiser   +7 more
openaire   +2 more sources

P-Selectin Antagonism in Inflammatory Disease

Current Pharmaceutical Design, 2010
Inflammation plays a fundamental role in many chronic diseases, including atherosclerosis associated cardiovascular disease. Adhesion of immune cells plays a critical role in the inflammatory response and indeed the pathophysiology of inflammatory related diseases.
Kevin J, Woollard, Jaye, Chin-Dusting
openaire   +2 more sources

Targeting P-selectin in acute pancreatitis

Expert Opinion on Therapeutic Targets, 2010
Acute pancreatitis (AP) is a multifactorial disorder not fully understood yet. In particular, the pathogenetic pathways promoting a severe life-threatening course of AP are the subject of ongoing investigations. P-selectin has been shown to play a central role in the complex pathophysiology in AP as well as various other inflammatory conditions.P ...
Thilo, Hackert, Markus W, Büchler, Jens, Werner   +2 more
openaire   +2 more sources

P-selectin as a candidate target in atherosclerosis

Biochemical Pharmacology, 2003
P-selectin is of critical importance in early atherogenesis by initiating leukocyte rolling at the site of endothelial injury. In order to validate P-selectin as a candidate target for the development of anti-atherogenic strategies, we wanted to obtain quantitative information on P-selectin expression, and identify novel peptide-based lead structures ...
Tom J M, Molenaar, Jaap, Twisk, Sonja A M, de Haas, Niels, Peterse, Bram J C P, Vogelaar, Steven H, van Leeuwen, Ingrid N, Michon, Theo J C, van Berkel, Johan, Kuiper, Erik A L, Biessen   +9 more
openaire   +2 more sources

P-selectin paradox and dementia of the Alzheimer type: Circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised

Scandinavian Journal of Clinical and Laboratory Investigation, 2013
Knowledge concerning the neurobiological importance of platelets in Alzheimer's disease (AD) is sparse. P-selectin, which is located together with β-amyloid precursor proteins in platelet α-granules, is also found in endothelial cells. Upon activation, P-selectin is relocated to cell surfaces where it acts as a receptor.
Petter, Järemo, Micha, Milovanovic, Caroline, Buller, Staffan, Nilsson, Bengt, Winblad   +4 more
openaire   +2 more sources

Therapeutic Targeting of P-Selectin in Atherosclerosis

Inflammation & Allergy-Drug Targets, 2007
P-selectin is an inflammatory adhesion molecule expressed on activated platelets and endothelial cells. The role of inflammatory cells and adhesion molecules in the development and progression of vascular diseases has been well studied in the past two decades and it is now recognised that many of the cellular and molecular events that underlie ...
Kevin J, Woollard, Jaye, Chin-Dusting
openaire   +2 more sources

Plasma levels of P-selectin are determined by platelet turn-over and the P-selectin Thr715Pro polymorphism

Thrombosis Research, 2008
Plasma levels of soluble P-selectin (sP-selectin) are often used to demonstrate platelet activation.We determined sP-selectin in a variety of disorders characterized by high or low platelet counts and compared their levels with those in healthy subjects.
Simon, Panzer, Sergio, Rosales, Heinz, Gisslinger, Lea, Jungbauer, Alexandra, Kaider, Paul, Knöbl, Christian, Sillaber, Ingrid, Pabinger   +7 more
openaire   +2 more sources