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Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution in Mice. [PDF]

open access: yesArterioscler Thromb Vasc Biol
Kral-Pointner JB   +18 more
europepmc   +1 more source
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P-selectin in arterial thrombosis

Zeitschrift f�r Kardiologie, 2004
P-selectin is a transmembrane protein present in the alpha granules of platelets and the Weibel-Palade bodies of endothelial cells. Following activation, it is rapidly translocated to the cell surface. P-selectin expression in platelets has been shown to be elevated in disorders associated with arterial thrombosis such as coronary artery disease, acute
M, Merten, P, Thiagarajan
openaire   +2 more sources

Uncharged P-selectin blockers

Glycoconjugate Journal, 2003
The blocking potency of P- and L-selectin was studied for certain small molecule mannosides and their polyacrylamide (PAA, 30 kDa) conjugates in comparison to SiaLe(x) and fucoidan. Two experimental systems were used: (1) solid phase static assay based on recombinant selectins, and (2) P-selectin dependent rat peritoneal inflammation. betaMan-SC6H4NO2-
Pochechueva, T.V.   +9 more
openaire   +2 more sources

The roles of P-selectin in cancer cachexia

Medical Oncology, 2023
P-selectin, a cell adhesion molecule of the selectin family, is expressed on the surface of activated endothelial cells (ECs) and platelets. Binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) supports the leukocytes capture and rolling on stimulated ECs and increases the aggregation of leukocytes and activated platelets. Cancer cachexia
Tingting Ling   +3 more
openaire   +2 more sources

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo

Blood, 2000
Selectin-dependent rolling is the earliest observable event in the recruitment of leukocytes to inflamed tissues. Several glycoproteins decorated with sialic acid, fucose, and/or sulfate have been shown to bind the selectins. The best-characterized selectin ligand is P-selectin glycoprotein-1 (PSGL-1) that supports P-selectin– dependent rolling in ...
K E, Norman   +7 more
openaire   +2 more sources

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