Results 171 to 180 of about 53,857 (243)

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells. [PDF]

Nat Commun
Zhang P, Li X, Liang J, Zheng Y, Tong Y, Shen J, Chen Y, Han P, Chu S, Liu R, Zheng M, Zhai Y, Tang X, Zhang C, Qu H, Mi P, Chai J, Yuan D, Li S.   +18 more
europepmc   +1 more source

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Tumor-educated-platelets interact with breast cancer-stem-cells via P-selectin-PSGL1 and ensure stemness and metastasis through WNT-β-catenin-VEGF-VEGFR2 intra-cellular signaling: therapeutic modulation by aspirin. [PDF]

Breast Cancer Res
Guha A, Sultana J, Bhuniya A, Chakravarti M, Bera S, Sarkar A, Dhar S, Choudhury PR, Das P, Das J, Ganguly N, Guha I, Bairagya D, Das T, Alam N, Ghosh I, Hajra S, Barik S, Mukherjee KK, Baral R, Bose A, Banerjee S.   +21 more
europepmc   +1 more source

Pregnancy shifts endothelial progenitor cell morphology and function: Role of metabolism, pro‐inflammatory cytokines and fetal sex

The Journal of Physiology, Volume 604, Issue 11, Page 4585-4604, 1 June 2026.
Abstract figure legend We recruited non‐pregnant women (NP), women in early pregnancy (EP) and late pregnancy (LP) for isolation of endothelial colony forming cells (ECFCs) via density gradient centrifugation. Plasma supernatant was collected for analysis of markers of glucose and lipid metabolism (fasting glucose, triglycerides, cholesterol, low ...
Marie‐Therese Weiser‐Fuchs, Andreas Jantscher, Simone Tischler, Elena Osto, Lusik Balayan, Hubert Scharnagl, Gabriele Jäger, Bettina Amtmann, Azra Kulovic‐Sissawo, Sabrina Puster, Herbert Fluhr, Barbara Obermayer‐Pietsch, Christina Stern, Ursula Hiden, Evelyn Jantscher‐Krenn   +14 more
wiley   +1 more source

Two-in-one nanoparticle platform induces a strong therapeutic effect of targeted therapies in P-selectin-expressing cancers. [PDF]

Sci Adv
Koshrovski-Michael S, Ajamil DR, Dey P, Kleiner R, Tevet S, Epshtein Y, Green Buzhor M, Khoury R, Pozzi S, Shenbach-Koltin G, Yeini E, Woythe L, Blau R, Scomparin A, Barshack I, Florindo HF, Lazar S, Albertazzi L, Amir RJ, Satchi-Fainaro R.   +19 more
europepmc   +1 more source

Platelet glycoprotein VI modulates leukocyte characteristics in sepsis‐induced systemic inflammatory response in male mice

Physiological Reports, Volume 14, Issue 12, June 2026.
Abstract Platelets are responsible for maintaining vascular integrity through the process of hemostasis with glycoprotein VI (GPVI) acting as a major receptor for platelet activation. Interestingly, platelet participation in inflammation is an evolving concept with few studies exploring GPVI in the framework of inflammation and even less in the context
Adam Corken, Jerry Ware, Keshari M. Thakali   +2 more
wiley   +1 more source

Soluble P-Selectin as an Indicator of Cutaneous Microangiopathy in Uncomplicated Young Patients with Type 1 Diabetes. [PDF]

Life (Basel)
Neubauer-Geryk J, Myśliwiec M, Zorena K, Bieniaszewski L.   +3 more
europepmc   +1 more source

Intact quantitation and evaluation of a PEG-glycosulfopeptide as a therapeutic P-selectin antagonist. [PDF]

RSC Adv
Park DD, Park SS, Dai E, Haller CA, Wong DJ, Wever WJ, Cummings RD, Chaikof EL.   +7 more
europepmc   +1 more source