Results 151 to 160 of about 24,158,011 (265)

Understanding exosomes: A history of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), including exosomes, have emerged as fundamental regulators of cell‐to‐cell communication and are increasingly recognized for their therapeutic and diagnostic promise. While EV research has expanded remarkably over the past two decades, the discipline is rooted in a much longer history of observations ...
Richard J. Miron, Paras Ahmad, Anton Sculean   +2 more
wiley   +1 more source

Value of adhesion molecules for evaluating the efficiency of therapy for ulcerative colitis and Crohn's disease

Терапевтический архив, 2014
AIM: To define the value of adhesion molecules (sVCAM-1 integrin, P-selectin, E-selectin, and L-selectin) for the prediction and evaluation of the efficiency of treatment in patients with ulcerative colitis (UC) and Crohn's disease/MATERIAL AND METHODS ...
A I Parfenov, O N Boldyreva, I N Ruchkina, O V Kniazev, V É Sagynbaeva, P L Shcherbakov, S G Khomeriki, L B Lazebnik, A G Konopliannikov   +8 more
doaj  

Functional validation of a modified platelet desialylation test for immune and hereditary thrombocytopenias

Transfusion Medicine, EarlyView.
Abstract Background Thrombocytopenia arises from heterogeneous inherited and acquired disorders, and identifying the underlying platelet clearance mechanisms remains challenging. Platelet desialylation, characterised by loss of sialic acid and consequent exposure of terminal β‐galactose residues recognised by the Ashwell–Morell receptor, represents an ...
Karen Nogueira Chinoca Ziza, Thamy Caroline Silva, Mateus Domentino, Marina Cavalcanti Albuquerque Veiga Conrado, João Vitor Bernardo Oliveira, Felipe Augusto Rós, Caroline Gabe, Elyse Moritz, Akemi Chiba, Paula Villaça, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Dante Langhi, Carla Luana Dinardo   +14 more
wiley   +1 more source

Downscaling to small‐volume storage bags supports platelet quality and efficient use of cold‐stored platelets for preclinical studies

Transfusion, EarlyView.
Abstract Background To maximize the utilization of cold‐stored platelets (CSPs) in preclinical research, the use of small‐volume storage bags (mini‐bags) or tubes would allow multiple treatment groups to be investigated from a single component. It is necessary to determine the effect of using downscaled storage formats on CSP quality and function ...
Janhavi Mahajan, Matthew P. Padula, Denese C. Marks, Lacey Johnson   +3 more
wiley   +1 more source

A functionally distinct HPA‐1a‐specific alloantibody associated with fetal/neonatal alloimmune thrombocytopenia that activates platelets via FcγRIIa

Transfusion, EarlyView.
Abstract Background Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies directed against fetal platelet antigens, most commonly human platelet antigen‐1a (HPA‐1a). These antibodies mediate platelet destruction and can lead to fetal and neonatal thrombocytopenia severe enough to cause life‐threatening organ bleeds ...
Huiying Zhi, Cathy Paddock, Daniel Villalobos‐Garcia, Janita Oosterhoff, Heng Zhang, Gestur Vidarsson, Renren Wen, Jieqing Zhu, Debra Newman, Peter J Newman   +9 more
wiley   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Continuous agitation induces aggregate formation in cold‐stored platelets during extended storage in platelet additive solution

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Reduced metabolic activity of cold‐stored platelets (CSPs) has led to the assumption that agitation is not required during cold storage. However, guidelines from the Food and Drug Administration state that agitation is ‘optional’ and there is a degree of international variability described in the literature.
Janhavi Mahajan, Pearl Lei, Christopher Roan, Matthew P. Padula, Denese C. Marks, Lacey Johnson   +5 more
wiley   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Peripheral non‐invasive focused ultrasound alleviates constipation by reducing gastrointestinal inflammation

Experimental Physiology, EarlyView.
Abstract Constipation affects approximately 20% of the US population, with diverse treatment options available due to the unclear onset and causes of the condition. Recently, focused ultrasound (FUS) has been proposed as a novel, non‐invasive peripheral neuromodulatory treatment that may reduce this inflammation.
Dia Shah, Kainat Akhtar, Dev Dwivedi, Amal Siddiqui, Griffin Haggas, Nicole Forman, Tatiana Gervase, Yifan Kao, John Chen, Julia Brzac, Eric Molho, Damian Shin   +11 more
wiley   +1 more source

Tumor-Associated Platelets Suppress T-cell Function and Promote Immune Evasion in TNBC via the P-selectin/P-selectin Glycoprotein Ligand 1 Pathway. [PDF]

Cancer Res Commun
Smith-Oliver MR, Gautam D, Petrarca GC, Sullivan ME, Clarke EM, Goggi G, Spasic M, Kane N, Brown J, Roweth HG, Baginska J, Garrido-Castro AC, Davenport P, McAllister SS, Battinelli EM.   +14 more
europepmc   +1 more source