Results 141 to 150 of about 24,158,011 (265)

A distinct profile of six soluble adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin, L-selectin and P-selectin) in rheumatoid arthritis.

, 1997
Soluble forms of ICAM-1, VCAM-1, E-selectin, L-selectin, P-selectin and, more recently, ICAM-3 are known to exist in human serum and have elevated levels in numerous diseases.
Simmons, DL, Buckley, Christopher, Collins, I, Buckley, CD, Wordsworth, P, Littler, A.J., Littler, AJ, Wordsworth, Bryan, Martinson, J   +8 more
core   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

P-selectin components and simulation system.

, 2015
(A) Schematic representation of P-selectin domain components. (B) Maximal components of the P-selectin-PSGL-1 complex for the simulations, which included the Lec, EGF, CR1 and CR2 domains of P-selectin and the SGP-3 ligand of PSGL-1.
Mian Long (163806), Yan Zhang (8098), Shouqin Lü (163792), Shenbao Chen (692011), Debin Mao (207672)   +4 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

P-selectin polymorphism Thr715Pro impairs terminal glycosylation of P-selectin

, 2012
Auf der Oberfläche von aktivierten Blutplättchen löst P-Selektin die Plättchen-Leukozyten Interaktion aus und fördert so die Thrombogenese. Das P-Selektin Gen (SELP) ist polymorph und es konnten 17 nicht-synonyme Polymorphismen identifiziert werden.
Subramanian, Hariharan
core  

E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice

, 2007
In multiple sclerosis and in its animal model experimental autoimmune encephalomyelitis (EAE), inflammatory cells migrate across the endothelial blood-brain barrier (BBB) and gain access to the CNS.
Engelhardt, B., Martin Wild, Engelhardt, Britta, Wild, Martin, Deutsch, Urban, Wild, M., Dietmar Vestweber, Doring, A., Britta Engelhardt, Döring, Axinia, Axinia Döring, Vestweber, Dietmar, Vestweber, D., Deutsch, U., Urban Deutsch   +14 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

肿瘤患者血浆可溶性P-选择素的检测及意义 附视频

Zhongguo shiyan zhenduanxue, 1998
探讨肿瘤患者血浆可溶性Ｐ－选择素（Ｐ－ｓｅｌｅｃｔｉｎ）检测的意义。方法用ＥＬＩＳＡ法检测１１６例不同肿瘤患者血浆中可溶性Ｐ－ｓｅｌｅｃｔｉｎ的含量。结果各组肿瘤患者血浆可溶性Ｐ－ｓｅｌｅｃｔｉｎ均明显高于正常人对照组（Ｐ＜０．０５或Ｐ＜０．０１）。结论肿瘤患者血浆可溶性Ｐ－ｓｅｌｅｃｔｉｎ含量与正常人有差异，检测可溶性Ｐ－ｓｅｌｅｃｔｉｎ有可能成为肿瘤辅助诊断的一项有价值的指标。
徐军发, 官成浓, 陈小芳, 林满华, 周克元, 广东医学院检验系   +5 more
doaj  

P-Selectin [PDF]

, 2020
openaire   +1 more source

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source