Results 131 to 140 of about 24,158,011 (265)
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk +18 more
wiley +1 more source
The sorting nexin Snx21 promotes flotillin‐mediated endocytosis
The FEBS Journal, EarlyView.In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs +9 more
wiley +1 more source
, 2012 BACKGROUND: Plateletpheresis components have been shown to contain p-selectin-positive platelets after collection and storage. P-selectin mediates binding of activated platelets to granulocytes and monocytes.
Ragno, G. +7 more
core +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Aim A growing body of research supports an association between periapical inflammation and an increased risk of various systemic effects. However, there is currently no scientific evidence demonstrating a causal relationship between this inflammation and changes in epithelial or endothelial permeability in patients with apical periodontitis ...
Loredana Bergandi +9 more
wiley +1 more source
, 2011 Background: An adverse pattern of blood lipids and atherosclerosis begin in childhood. Unfortunately, data for children and adolescents, particularly those in the Indian population, are scarce.
Gururajan, P. +4 more
core +1 more source
Testing for Non‐Severe Heritable Platelet Function Disorders
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley +3 more
wiley +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction Heparin‐induced thrombocytopenia (HIT) is a rare but potentially life‐threatening, immune‐mediated adverse reaction to heparin. PF4‐dependent immunoassays are sensitive screening tests, but they detect both platelet‐activating and nonactivating antibodies; therefore, positive results require interpretation in clinical context and,
Elvira Maličev +4 more
wiley +1 more source
Increased levels of soluble P-selectin in hypercholesterolemic patients
, 1998 BACKGROUND: Hypercholesterolemia is considered a major risk factor for the development of atherosclerosis. Enhanced lipid peroxidation and persistent platelet activation can be observed in vivo in hypercholesterolemic patients and may have ...
Bittolo Bon G. +9 more
core
Zhongguo shiyan zhenduanxue, 1998 探讨肿瘤患者血浆可溶性Ｐ－选择素（Ｐ－ｓｅｌｅｃｔｉｎ）检测的意义。方法用ＥＬＩＳＡ法检测１１６例不同肿瘤患者血浆中可溶性Ｐ－ｓｅｌｅｃｔｉｎ的含量。结果各组肿瘤患者血浆可溶性Ｐ－ｓｅｌｅｃｔｉｎ均明显高于正常人对照组（Ｐ＜０．０５或Ｐ＜０．０１）。结论肿瘤患者血浆可溶性Ｐ－ｓｅｌｅｃｔｉｎ含量与正常人有差异，检测可溶性Ｐ－ｓｅｌｅｃｔｉｎ有可能成为肿瘤辅助诊断的一项有价值的指标。
徐军发 +4 more
doaj
Immunology, EarlyView.Human plasmacytoid dendritic cell‐based vaccines efficiently migrate from blood to lymph nodes and prime naive T cells in humanised mice. Irradiation‐induced CD62L shedding, mediated by p38 MAP kinase and ADAM17, is involved in the regulation of PDC migration to secondary lymphoid organs in this model.
Estelle Leplus +11 more
wiley +1 more source