Results 41 to 50 of about 18,638,167 (297)
PLoS ONE, 2020 Acute inflammation begins with leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin on inflamed endothelium and platelets. In pathologic conditions, this process may contribute to secondary organ damage, like sepsis-induced liver ...
Fong Wilson Lam +5 more
doaj +1 more source
Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics [PDF]
, 2011 Colloidal gold particles with functionalized organic shells were applied as novel selectin binders. The ligand shell was terminated with different monocyclic carbohydrate mimetics as simplified analogs of the sLe(x) unit found in biological selectin ...
Dekaris, Vjekoslav +7 more
core +1 more source
P-selectin binds to bacterial lipopolysaccharide [PDF]
European Journal of Immunology, 1998 Multiple organ failure associated with disseminated intravascular coagulation is a frequent complication in septic shock patients. Accumulation of platelets and neutrophils in the organs contributes to the manifestation of lipopolysaccharide (LPS)-induced organ failure.
R, Malhotra +3 more
openaire +2 more sources
تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی [PDF]
مجله دانشگاه علوم پزشکی سبزوار, 2020 زمینه و هدف مولکولهای چسبان، نشانگرهای سلولی شناسایی روند تشکیل پلاک آترواسکلروزی دیواره اندوتلیال عروق هستند. هدف، بررسی تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی، پس از هشت هفته تمرین هوازی تداومی و تناوبی بود. مواد و روشها
لادن حسینی ابریشمی +2 more
doaj
Journal of Nuclear Medicine, 2019 P-selectin is an adhesion molecule translocated to the surface of endothelial cells and platelets under inflammatory stimuli, and its potential as a biomarker in inflammatory conditions has driven preclinical studies to investigate its application for ...
L. Perkins, C. Anderson, E. Novelli
semanticscholar +1 more source
Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]
, 2017 Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette +11 more
core +2 more sources
Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry
Research and Practice in Thrombosis and Haemostasis, 2020 Background Hemostatic clots have a P‐selectin positive platelet core covered with a shell of P‐selectin negative platelets. Objective To develop a new human blood microfluidic assay to interrogate core/shell mechanics.
Michael E. DeCortin +2 more
doaj +1 more source
Innate immune basis for rift valley fever susceptibility in mouse models [PDF]
, 2017 Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the
Bruhns, Pierre +7 more
core +3 more sources
A Novel Glycosulfopeptide Binds to P-selectin and Inhibits Leukocyte Adhesion to P-selectin [PDF]
Journal of Biological Chemistry, 1999 P-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric membrane mucin on leukocytes that binds selectins. The molecular features of PSGL-1 that determine this high affinity binding are unclear. Here we demonstrate the in vitro synthesis of a novel glycosulfopeptide (GSP-6) modeled after the extreme N terminus of PSGL-1, which has been predicted to be ...
A, Leppänen +9 more
openaire +2 more sources
Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]
, 2018 Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz +12 more
core +1 more source