Results 51 to 60 of about 18,638,167 (297)
Affinity and Kinetic Analysis of P-selectin Binding to P-selectin Glycoprotein Ligand-1 [PDF]
Journal of Biological Chemistry, 1998 Leukocytes use the cell-surface mucin P-selectin glycoprotein ligand-1 (PSGL-1) to tether to and roll on P-selectin on activated endothelial cells and platelets. By using surface plasmon resonance, we measured the affinity and kinetics of binding of soluble monomeric human P-selectin to immobilized PSGL-1 from human neutrophils.
P, Mehta, R D, Cummings, R P, McEver
openaire +2 more sources
Thrombin-anti-thrombin levels and patency of arterio-venous fistula in patients undergoing haemodialysis compared to healthy volunteers : a prospective analysis [PDF]
, 2013 Peer reviewedPublisher ...
Brittenden, Julie +4 more
core +6 more sources
Force-dependent calcium signaling and its pathway of human neutrophils on P-selectin in flow
Protein & Cell, 2017 P-selectin engagement of P-selectin glycoprotein ligand-1 (PSGL-1) causes circulating leukocytes to roll on and adhere to the vascular surface, and mediates intracellular calcium flux, a key but unclear event for subsequent arresting firmly at and ...
Bing Huang +5 more
doaj +1 more source
Further Findings Concerning Endothelial Damage in COVID-19 Patients
Biomolecules, 2021 Systemic vascular damage with micro/macro-thrombosis is a typical feature of severe COVID-19. However, the pathogenesis of this damage and its predictive biomarkers remain poorly defined. For this reason, in this study, serum monocyte chemotactic protein
Monica Gelzo +12 more
doaj +1 more source
P-selectin-mediated platelet adhesion promotes tumor growth
OncoTarget, 2015 Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and ...
Cuiling Qi +15 more
semanticscholar +1 more source
Remote assessment of platelet function in patients with acute stroke or transient ischaemic attack [PDF]
, 2017 Background: Antiplatelets reduce recurrence after cerebral ischaemia. The international TARDIS trial assessed the safety and efficacy of intensive (combined aspirin, dipyridamole and clopidogrel) versus guideline (aspirin and dipyridamole, or clopidogrel
Jane May +11 more
core +4 more sources
International Journal on Biological Sciences, 2015 Studies have indicated that platelets play an important role in tumorigenesis, and an abundance of platelets accumulate in the ovarian tumor microenvironment outside the vasculature.
Cuiling Qi +11 more
semanticscholar +1 more source
BMC Medical Genetics, 2012 Background E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals. Methods Five hundred twenty
Wu Semon +7 more
doaj +1 more source
Glycopeptide Analogues of PSGL-1 Inhibit P-Selectin In Vitro and In Vivo
Nature Communications, 2015 Blockade of P-selectin (P-sel)/PSGL-1 interactions holds significant potential for treatment of disorders of innate immunity, thrombosis and cancer. Current inhibitors remain limited due to low binding affinity or by the recognized disadvantages inherent
Venkata R. Krishnamurthy +13 more
semanticscholar +1 more source
Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]
, 2017 NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina +8 more
core +1 more source