Results 131 to 140 of about 3,383,900 (322)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Curves on a quadric surface over $\overline{\mathbb {F}}_p$

open access: yesLe Matematiche, 2012
Here (following a paper by Giuffida, Maggioni and Re) we study the existence of curve $C\in \vert \mathcal {O}_{\mathbb {P}^1\times \mathbb {P}^1}(a,b)\vert$defined over small fields and with $h^0(C,\mathcal {O}_C(x,y))\cdot h^1(C, \mathcal {O}_C(x,y))=0$
Edoardo Ballico
doaj  

Evaluation of Pile Lateral Bearing Capacity-Based on Cone Penetration Test Results

open access: yesAdvances in Civil Engineering
To analyze the bearing capacity of pile foundations under horizontal loads, a new method based on the piezocone penetration test (CPTU) data for calculating pile p-y curves was proposed.
Yi He   +4 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Prediksi Kurva P-h dan Nilai Kekerasan pada Indentasi Bulat Berbasis Pendekatan Tegangan Representatif (?r)

open access: yesJurnal Energi Dan Manufaktur, 2016
Abstrak: Dalam penelitian ini model elemen hingga untuk indentasi bulat (Spherical) telah dikembangkan dan divalidasi. Sebuahpendekatan untuk memprediksi kurva P-h dari sifat material konstitutif telah dikembangkan dan diuji berdasarkanhubungan antara ...
I Nyoman Budiarsa
doaj  

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