Results 91 to 100 of about 24,766 (261)

Alteration in oral and non‐oral tissues in ligature‐induced periodontitis mice with the Alzheimer's disease risk factor APOE4

European Journal of Oral Sciences, EarlyView.
Abstract The APOE4 gene, particularly the ε4 allele, is linked to susceptibility to Alzheimer's disease, and periodontitis can cause pathological changes in multiple organs, but combined effects of these conditions and the impact of tumor necrosis factor (TNF)‐α regulation on the combined effects remain unclear.
Ae Ri Kim, Yun‐Jung Yoo, Eun‐Jung Bak   +2 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA/CD151/ITGB1 signaling

Journal of Translational Medicine
Background Cervicovaginal microbiota dysbiosis has been implicated in the progression of cervical cancer. Recent studies have reported an increased abundance of Porphyromonas species in the vaginal microbiota of cervical cancer patients.
Xiuting Huang, Yuan Zhuang, Rui Wang, Jing Qu, Yuanyang Tan, Liang Li, Wenjun Pan, Huilong Nie, Kefeng Li, Yujing Lin, Liutong Yi, Xiaoyu Feng, Huimin Lan, Guangxue Wang, Xiantao Zeng, Zhenqi Jiang, De-Yun Wang, Yongkang Qiao, Yan Yan   +18 more
doaj   +1 more source

Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review

Frontiers in Oral Health
ObjectivePorphyromonas gingivalis, a major periodontal pathogen, interacts with other oral microbes through quorum sensing, enhancing its growth and virulence, which contributes to periodontitis.
Zelda Ziyi Zhao, Wenwen Shan, Lifeng Guo, Chun Hung Chu, Jing Zhang, Jing Zhang   +5 more
doaj   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Heterogeneity of virulence factors among Porphyromonas gingivalis clinical isolates from patients with chronic generalized periodontitis

Инфекция и иммунитет
The development of chronic generalized periodontitis occurs due to a combination of a several causes, among which the leading role is assigned to periodontal pathogens, which include P. gingivalis. Among P.
I. V. Koroleva, Ekaterina S. Mikhailova, K. A. Privalova, L. A. Ermolaeva, S. A. Tumanova, A. N. Suvorov   +5 more
doaj   +1 more source

The Complex World of Toothpaste Diversity, Meeting Patient Clinical Needs. An Umbrella Review

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Background Amidst numerous recent advancements in toothpaste formulations and active ingredients, some clinicians may believe all toothpastes are similar despite differences in their active ingredients and corresponding clinical application.
Jeanie Suvan, Crystal Marruganti
wiley   +1 more source

Periodontal Status of Type 1 Diabetes Mellitus and Healthy Pregnant Women: A Case–Control Pilot Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Aims This cross‐sectional ‘case–control’ pilot study aimed to compare the size of periodontal wounds, periodontal status and total inflammatory burden between pregnant women with type 1 diabetes mellitus (T1DM) and non‐diabetic pregnant women. Methods Fifteen T1DM pregnant women and 15 healthy pregnant women were included. Clinical parameters (
M. Janc, M. Tomažič, M. Pirc, U. Skalerič, R. Schara   +4 more
wiley   +1 more source

Harnessing Natural Quorum Sensing Inhibitors to Prevent Porphyromonas gingivalis-Induced Oral Squamous Cell Carcinoma: An Innovative Approach

Galician Medical Journal
The quest for effective cancer preventive strategies has led researchers to explore novel ways that go beyond conventional treatments. One such innovative method involves using natural quorum sensing inhibitory compounds to target Porphyromonas ...
Naji Naseef Pathoor, Pitchaipillai Sankar Ganesh   +1 more
doaj   +1 more source

Inflammation‐Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF‐κB Crosstalk

International Endodontic Journal, EarlyView.
ABSTRACT Background Inflammation critically determines dental pulp regenerative outcomes, with dental pulp stem cells (DPSCs) orchestrating tissue homeostasis through differentiation, self‐renewal and immunomodulation processes dynamically regulated by Wnt/β‐catenin and NF‐κB signaling crosstalk.
V. Rajasekar, M. Huang, M. M. Abdalla, P. Neelakantan, C. K. Y. Yiu   +4 more
wiley   +1 more source