Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
Cell Reports, 2019 Summary: Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS).
Raquel Buj +23 more
doaj +1 more source
Warty carcinoma of uterine cervix - review of the literature and case report [PDF]
, 2020 Introduction. The Histological Classification of Epithelial Tumors of the Uterine Cervix of the World Health Organization includes inter alia warty carcinoma as a variant of squamous cell carcinoma.
Balalau, Oana Denisa +3 more
core +3 more sources
Veterinary Sciences, 2022 Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest.
Leni Maylina +3 more
doaj +1 more source
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis [PDF]
, 2011 Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of
Andrew Edwards +13 more
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P16 expression in human breast carcinoma and its relationship to clinicopathological parameters
Advanced Biomedical Research, 2023 Background: p16 is a cyclin-dependent kinase inhibitor and a cardinal regulator of the cell cycle. The relationship between p16 overexpression and poor prognosis of breast cancer has been reported in some studies.
Fereshteh Mohammadizadeh, Farnaz Nasri
doaj +1 more source
$\alpha$ Centauri A as a potential stellar model calibrator: establishing the nature of its core
, 2018 Understanding the physical process responsible for the transport of energy in the core of $\alpha$ Centauri A is of the utmost importance if this star is to be used in the calibration of stellar model physics.
Campante, T. L. +4 more
core +1 more source
Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]
, 2014 We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura +10 more
core +1 more source
Expression of CK7, CK19 and p16 in HPV-mediated oropharyngeal squamous cell carcinoma [PDF]
PeerJBackground The incidence of oropharyngeal squamous cell carcinoma (OPSCC) mediated by human papilloma virus (HPV) has been steadily increasing worldwide.
Qizhang Yan +8 more
doaj +2 more sources
High prevalence of p16 staining in malignant tumors.
PLoS ONE, 2022 p16 (CDKN2A) is a member of the INK4 class of cell cycle inhibitors, which is often dysregulated in cancer. However, the prevalence of p16 expression in different cancer types is controversial.
Noémi De Wispelaere +29 more
doaj +1 more source
A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing. [PDF]
, 2012 Background. Next-generation sequencing of cancers has identified important therapeutic targets and biomarkers. The goal of this pilot study was to compare the genetic changes in a human papillomavirus- (HPV-)positive and an HPV-negative head and neck ...
Barrett, John W +19 more
core +3 more sources