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Journal of Clinical Pathology, 2018 Thep16gene belongs toINK4family of genes and is made up of four members: p16INK4A, p15INK4B, p18INK4Cand p19INK4D, all of which share biological properties, namely, inhibition of cell growth and tumour suppression. Afterp53,p16is the second most common tumour suppressor gene. It has been regarded as the familial melanoma gene.
Stefano Serra, Runjan Chetty
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Treatment failure patterns are similar between p16− and p16+ oropharyngeal squamous cell carcinomas
Laryngoscope Investigative Otolaryngology, 2022 Background The incidence of p16+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing. The notion that p16+ OPSCC has a propensity for atypical and disseminating metastasis has gained traction.
Chelsea S. Hamill +13 more
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p16(INK4a) translation suppressed by miR-24. [PDF]
PLoS ONE, 2008 Expression of the tumor suppressor p16(INK4a) increases during aging and replicative senescence.Here, we report that the microRNA miR-24 suppresses p16 expression in human diploid fibroblasts and cervical carcinoma cells.
Ashish Lal +13 more
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Role of p16 Immunohistochemistry in Cervical Intraepithelial Neoplasia [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: p16 or p16/INK4a is a Cyclin Dependant Kinase Inhibitor 2 (CDKN2) and is upregulated in HPV-related lesions. Therefore, p16 can be considered an indirect marker for altered HR-HPV and growth cycle transformation.
NICHOLAS JOSEPH DCUNHA +2 more
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Scientific Reports, 2021 The eighth edition of the TNM classifies oropharyngeal squamous cell carcinomas (OSCCs) depending on p16 status. Some imaging features are reportedly associated more frequently with p16-positive (P16+) OSCC than p16-negative (p16−) OSCC.
Jean-Michel Trinh +3 more
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Scientific Reports, 2021 p16 inhibits cyclin-dependent kinases and regulates senescence-mediated arrest as well as p21. Nuclear p16 promotes G1 cell cycle arrest and cellular senescence.
Sayo Ueda +8 more
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Clinical impact of p16 positivity in nasopharyngeal carcinoma
Laryngoscope Investigative Otolaryngology, 2022 Purpose The clinical characteristics and prognosis of HPV‐related nasopharyngeal cancer (NPC) remain controversial. The relationship between p16 status and outcome was retrospectively investigated in the NPC patients.
Yuri Shimizu +17 more
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Indian Journal of Pathology and Microbiology, 2022 Context: p16 is an important tumor suppressor gene and responsible for regulating the cell cycle. Diffuse positivity with p16 in the cervix and head/neck carcinomas can be regarded as a surrogate marker of the presence of high-risk human papillomavirus ...
Elçin Süren +5 more
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Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell line [PDF]
Korean Journal of Pediatrics, 2010 PurposeIt has been suggested that p16 has a role in glucocorticoid (GC)-related apoptosis in leukemic cells, but the exact mechanisms have yet to be clarified.
Sun-Young Kim +3 more
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Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]
, 2019 The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O. +9 more
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