Results 201 to 210 of about 212,746 (279)

Ageing‐Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1‐Meditated Ca2+ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice

Cell Proliferation, EarlyView.
During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi, Yusheng Zhang, Gong Chen, Jiru Zhang, Jing Liu, Hao Zhu, Minne Sun, Yu Duan   +7 more
wiley   +1 more source

Comment on Hasan et al. Clinico-Pathological Features and Immunohistochemical Comparison of p16, p53, and Ki-67 Expression in Muscle-Invasive and Non-Muscle-Invasive Conventional Urothelial Bladder Carcinoma. Clin. Pract. 2023, 13, 806-819. [PDF]

Clin Pract
Harsanyi S, Novakova ZV, Ziaran S, Danisovic L, Bevizova K.   +4 more
europepmc   +1 more source

HPV42 – a human papillomavirus classified as a low‐risk type with oncogenic potential

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Human papillomavirus (HPV) type 42 is a rare HPV type currently classified as “low‐risk” and belongs to the alpha genus. It has primarily been detected in benign vulvar papillomas and is predominantly associated with benign lesions such as anogenital warts.
Sven Niklas Burmann, Ulrike Wieland, Steffi Silling, Frank Oellig, David Chromy, Julia Hyun, Thilo Gambichler, Alexander Kreuter   +7 more
wiley   +1 more source

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues. [PDF]

EMBO J
Saul D, Jurk D, Doolittle ML, Kosinsky RL, Han Y, Zhang X, Franco AC, Kim SY, Wyles SP, Prakash YS, Monroe DG, Ferrucci L, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Khosla S, Passos JF.   +16 more
europepmc   +1 more source

‘There is more to life than HbA1c’: A comprehensive qualitative framework from the Hypo‐RESOLVE project evidencing the impacts of hypoglycaemia on the quality of life of adults living with type 1 or type 2 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims To develop a comprehensive, in‐depth understanding of the impacts of hypoglycaemia on the quality of life of adults living with type 1 (T1D) or type 2 diabetes (T2D). Methods Thirty‐one adults with T1D or T2D who experienced hypoglycaemia participated in semi‐structured interviews.
Philip A. Powell, Sé M. Frances, Bastiaan E. de Galan, Simon Heller, Jane Speight, Myriam Rosilio, Frans Pouwer, Mari‐Anne Gall, Christopher J. Child, Rory J. McCrimmon, Ken Tait, Jill Carlton, on behalf of the Hypo‐RESOLVE Consortium   +12 more
wiley   +1 more source

Trop2 expression, p16 expression status, and histologic subtype in carcinoma of the uterine cervix. [PDF]

Pathol Oncol Res
Hiller GGR, Wolf B, Forberger M, Freude A, Brambs CE, Droste S, Horn LC, Höhn AK.   +7 more
europepmc   +1 more source

Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte‐derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward, M. U. Shah, K. Lee, P. E. Squires, C. E. Hills   +4 more
wiley   +1 more source

p16 Examination Is not Sufficient [PDF]

Deutsches Ärzteblatt international, 2018
openaire   +2 more sources

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source