Results 31 to 40 of about 208,852 (280)
Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth. [PDF]
PLoS ONE, 2014 The INK4A locus codes for two independent tumor suppressors, p14ARF and p16/CDKN2A, and is frequently mutated in many cancers. Here we report a novel deletion/substitution from CC to T in the shared exon 2 of p14ARF/p16 in a melanoma cell line.
Richard T Williams +6 more
doaj +1 more source
Prognostic significance of p16 immunohistochemical expression in urothelial carcinoma
Surgical and Experimental Pathology, 2019 Background p16 is the protein product of most commonly involved gene in bladder carcinogenesis. Therefore, we performed an immunohistochemical study to evaluate association of p16 overexpression with prognostic parameters in bladder cancer.
Atif Ali Hashmi +5 more
doaj +1 more source
Taking stock of SLSN and LGRB host galaxy comparison using a complete sample of LGRBs [PDF]
, 2016 Long gamma-ray bursts (LGRBs) and superluminous supernovae (SLSNe) are both explosive transients with very massive progenitor stars. Clues about the nature of the progenitors can be found by investigating environments in which such transients occur ...
Hunt, L. K. +4 more
core +4 more sources
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
The International Journal of Biological Markers, 2016 Background p16 has been indicated as a suitable surrogate biomarker of HPV infection. The prognosis of p16-positive oropharynx tumors (OTs) of squamous cell carcinoma (SCC) histology is better than that of p16-negative tumors.
Marco Carlo Merlano +7 more
doaj +1 more source
A study on the correlation between HPV DNA and IHC P16 expression in cervical lesions [PDF]
Zhongguo aizheng zazhiBackground and purpose: Human papilloma virus (HPV) infection status is crucial for diagnosing cervical precancerous lesions and classifying cervical cancer.
WANG Haochen, JIA Liqing, YANG Yu, WANG Qian, YU Chengli, TIAN Tian, BI Rui, TU Xiaoyu, BAI Qianming, ZHU Xiaoli, ZHOU Xiaoyan, REN Min
doaj +1 more source
p16, pRb, and p53 in Feline Oral Squamous Cell Carcinoma
Veterinary Sciences, 2016 Feline oral squamous cell carcinoma (FOSCC) is a highly aggressive head and neck cancer in cats, but the molecular pathogenesis of this cancer is still uncertain.
Wachiraphan Supsavhad +3 more
doaj +1 more source
MicroRNA-551b expression profile in low and high-grade cervical intraepithelial neoplasia [PDF]
, 2018 OBJECTIVE: To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers ...
Bordi, G +7 more
core +1 more source
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]
, 2020 The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda +9 more
core +1 more source
IKKβ specifically binds to P16 and phosphorylates Ser8 of P16 [PDF]
Biochemical and Biophysical Research Communications, 2010 In spite of its central roles in cell cycle progression, senescence, and aging, knowledge about the posttranslational regulation of P16 (also known as INK4A and MTS1) remains limited. While it has been reported that P16 could be phosphorylated at Ser7, Ser8, Ser140, and Ser152, the corresponding kinases have not been identified yet. Here we report that
Yi, Guo +3 more
openaire +2 more sources