Results 31 to 40 of about 212,746 (279)

P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.

PLoS ONE, 2019
The P16 (CDKN2Aink4a) gene is an endogenous CDK4/6 inhibitor. Palbociclib (PD0332991) is an anti-CDK4/6 chemical for cancer treatment. P16 is most frequently inactivated by copy number deletion and DNA methylation in cancers. It is well known that cancer
Paiyun Li, Xuehong Zhang, Liankun Gu, Jing Zhou, Dajun Deng   +4 more
doaj   +1 more source

Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]

, 2014
We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura, Cayrol, Maria Florencia, Colombo, L., Cremaschi, Graciela Alicia, Díaz Flaqué, María Celeste, Klecha, Alicia Juana, Martinel Lamas, Diego José, Medina, Vanina Araceli, Paulazo, Maria Alejandra, Sterle, Helena Andrea, Valli, Eduardo   +10 more
core   +1 more source

Role of p16 testing in cervical cancer screening among HIV-infected women. [PDF]

PLoS ONE, 2017
p16 immunohistochemistry is used to evaluate for HPV-associated cervical intraepithelial neoplasia. The diagnostic performance of p16 in HIV infection is unclear.Between June-December 2009, HIV-infected women underwent Papanicolaou (Pap) smear, human ...
Christine J McGrath, Rochelle Garcia, Trong T Trinh, Barbra A Richardson, Grace C John-Stewart, Evans Nyongesa-Malava, Nelly R Mugo, Emily H Glynn, Samah R Sakr, Hugo De Vuyst, Michael H Chung   +10 more
doaj   +1 more source

Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status

Frontiers in Oncology
BackgroundThe incidence of oropharyngeal cancer (OPC) is increasing, due mainly to a rise in Human Papilloma Virus (HPV)-mediated disease. HPV-mediated OPC has significantly better prognosis compared with HPV-negative OPC, stimulating interest in ...
Jill M. Brooks, Yuanning Zheng, Kelly Hunter, Benjamin E. Willcox, Janet Dunn, Paul Nankivell, Olivier Gevaert, Hisham Mehanna, Hisham Mehanna   +8 more
doaj   +1 more source

Taking stock of SLSN and LGRB host galaxy comparison using a complete sample of LGRBs [PDF]

, 2016
Long gamma-ray bursts (LGRBs) and superluminous supernovae (SLSNe) are both explosive transients with very massive progenitor stars. Clues about the nature of the progenitors can be found by investigating environments in which such transients occur ...
Hunt, L. K., Japelj, J., Mannucci, F., Salvaterra, R., Vergani, S. D.   +4 more
core   +3 more sources

Prevalence and predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity cancer [PDF]

, 2012
Background The purpose of this study was to describe the relationship of p16 and epidermal growth factor receptor (EGFR) expression with survival in surgically treated patients who had oropharyngeal or oral cavity squamous cell carcinoma (SCC ...
Bradford, Carol R., Carey, Thomas E., Chandarana, Shamir P., Chanowski, Eric J. P., Chepeha, Douglas B., Cordell, Katrina G., Eisbruch, Avraham, Giordano, Thomas J., Kumar, Bhavna, Lee, Julia S., Moyer, Jeffrey S., Prince, Mark E., Sacco, Assuntina G., Wolf, Gregory T., Worden, Francis P.   +14 more
core   +1 more source

Warty carcinoma of uterine cervix - review of the literature and case report [PDF]

, 2020
Introduction. The Histological Classification of Epithelial Tumors of the Uterine Cervix of the World Health Organization includes inter alia warty carcinoma as a variant of squamous cell carcinoma.
Balalau, Oana Denisa, Gabriel Olaru, Octavian, Pena, Catalina Monica, Stanescu, Anca Daniela   +3 more
core   +3 more sources

The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco, Chen, Rong, Francis, Heather, Glaser, Shannon, Li, Siwen, Li, Xuesen, Meng, Fanyin, Wan, Ying, Wu, Nan, Zhang, Chunmei, Zhou, Bingru, Zhou, Tianhao, Zou, Ping   +12 more
core   +1 more source

Clinical characteristics and treatment outcome in p16 negative anal cancer

Acta Oncologica
Background: Anal squamous cell carcinoma (ASCC) is linked to human papillomavirus infection with p16 being positive in about 85% of cases. Overall survival (OS) of ASCC is 60%–80%. Prognosis in p16 negative (p16-) ASCC is worse with an OS of 30%–60%.
Catherine Burgos, Calin Radu, Sofia Heyman, Nina Cavalli-Björkman, Peter Nygren   +4 more
doaj   +1 more source

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Cell Reports, 2019
Summary: Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS).
Raquel Buj, Chi-Wei Chen, Erika S. Dahl, Kelly E. Leon, Rostislav Kuskovsky, Natella Maglakelidze, Maithili Navaratnarajah, Gao Zhang, Mary T. Doan, Helen Jiang, Michael Zaleski, Lydia Kutzler, Holly Lacko, Yiling Lu, Gordon B. Mills, Raghavendra Gowda, Gavin P. Robertson, Joshua I. Warrick, Meenhard Herlyn, Yuka Imamura, Scot R. Kimball, David J. DeGraff, Nathaniel W. Snyder, Katherine M. Aird   +23 more
doaj   +1 more source