Results 41 to 50 of about 208,852 (280)

Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration

Journal of Orthopaedic Surgery and Research, 2022
Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found to be highly expressed in a variety of tumor tissues.
Dechao Cai, Xiao Ma, Huihui Guo, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng   +6 more
doaj   +1 more source

Prevalence and predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity cancer [PDF]

, 2012
Background The purpose of this study was to describe the relationship of p16 and epidermal growth factor receptor (EGFR) expression with survival in surgically treated patients who had oropharyngeal or oral cavity squamous cell carcinoma (SCC ...
Bradford, Carol R., Carey, Thomas E., Chandarana, Shamir P., Chanowski, Eric J. P., Chepeha, Douglas B., Cordell, Katrina G., Eisbruch, Avraham, Giordano, Thomas J., Kumar, Bhavna, Lee, Julia S., Moyer, Jeffrey S., Prince, Mark E., Sacco, Assuntina G., Wolf, Gregory T., Worden, Francis P.   +14 more
core   +1 more source

P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.

PLoS ONE, 2019
The P16 (CDKN2Aink4a) gene is an endogenous CDK4/6 inhibitor. Palbociclib (PD0332991) is an anti-CDK4/6 chemical for cancer treatment. P16 is most frequently inactivated by copy number deletion and DNA methylation in cancers. It is well known that cancer
Paiyun Li, Xuehong Zhang, Liankun Gu, Jing Zhou, Dajun Deng   +4 more
doaj   +1 more source

Significance of P16INK4A hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study [PDF]

, 2006
BACKGROUND: Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivation; its incidence is extremely variable according to the type of tumor involved.
Adamo, V., Agnese, V., Agrusa, A., Altavilla, G., Augello, C., Bazan, V., Bruno, L., Calcara, D., Calo', V., Cicero, G., Colucci, G., Corsale, S., Crosta, A., DI FEDE, G., Fiorentino, E., Grassi, N., Latteri, F., Latteri, M., Morello, V., Rinaldi, G., Rodolico, V., Russo, A., Tomasino, R., Valerio, M.   +23 more
core   +1 more source

Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status

Frontiers in Oncology
BackgroundThe incidence of oropharyngeal cancer (OPC) is increasing, due mainly to a rise in Human Papilloma Virus (HPV)-mediated disease. HPV-mediated OPC has significantly better prognosis compared with HPV-negative OPC, stimulating interest in ...
Jill M. Brooks, Yuanning Zheng, Kelly Hunter, Benjamin E. Willcox, Janet Dunn, Paul Nankivell, Olivier Gevaert, Hisham Mehanna, Hisham Mehanna   +8 more
doaj   +1 more source

The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging

BMC Cancer, 2018
Background Tumor suppressor gene p16 promoter hypermethylation has been widely studied in colorectal cancer (CRC), yet its clinicopathological significance remains controversial.
Xiaoxia Ye, Mingming Mo, Simin Xu, Qingjin Yang, Minhua Wu, Junjie Zhang, Bin Chen, Jian Li, Yu Zhong, Qionglin Huang, Chun Cai   +10 more
doaj   +1 more source

The Chandra Dust Scattering Halo of Galactic Center transient Swift J174540.7-290015 [PDF]

, 2017
We report the detection of a dust scattering halo around a recently discovered X-ray transient, Swift J174540.7-290015, which in early February of 2016 underwent one of the brightest outbursts (F_X ~ 5e-10 erg/cm^2/s) observed from a compact object in ...
Baganoff, F., Corrales, L., Degenaar, N., Garmire, G., Haggard, D., Mon, B., Reynolds, M.   +6 more
core   +3 more sources

Reconstructing seasonality through stable-isotope and trace-element analyses of the Proserpine stalagmite, Han-sur-Lesse cave, Belgium : indications for climate-driven changes during the last 400 years [PDF]

, 2020
Fast-growing speleothems allow for the reconstruction of palaeoclimate down to a seasonal scale. Additionally, annual lamination in some of these speleothems yields highly accurate age models for these palaeoclimate records, making these speleothems ...
Claeys, Philippe, Goderis, Steven, J. De Winter, Niels, J. M. Van Malderen, Stijn, non-UU output of UU-AW members, Sinnesael, Matthias, Vanhaecke, Frank, Vansteenberge, Stef, Verheyden, Sophie   +8 more
core   +2 more sources

Clinical characteristics and treatment outcome in p16 negative anal cancer

Acta Oncologica
Background: Anal squamous cell carcinoma (ASCC) is linked to human papillomavirus infection with p16 being positive in about 85% of cases. Overall survival (OS) of ASCC is 60%–80%. Prognosis in p16 negative (p16-) ASCC is worse with an OS of 30%–60%.
Catherine Burgos, Calin Radu, Sofia Heyman, Nina Cavalli-Björkman, Peter Nygren   +4 more
doaj   +1 more source

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis [PDF]

, 2016
Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here,
Algül, Hana, Demir, Ihsan Ekin, Diakopoulos, Kalliope Nina, Einwächter, Henrik, Heikenwälder, Mathias, Kehl, Timo, Korneeva, Olga, Lesina, Marina, Morton, Jennifer, Sansom, Owen J., Saur, Dieter, Schmid, Roland Michael, Sipos, Bence, Sperveslage, Jan, Steiner, Jörg Manfred, Wang, Timothy Cragin, Wimmer, Margit, Wörmann, Sonja Maria   +17 more
core   +1 more source