Results 61 to 70 of about 210,208 (298)

$\alpha$ Centauri A as a potential stellar model calibrator: establishing the nature of its core

, 2018
Understanding the physical process responsible for the transport of energy in the core of $\alpha$ Centauri A is of the utmost importance if this star is to be used in the calibration of stellar model physics.
Campante, T. L., Cunha, M. S., Monteiro, M. J. P. F. G., Nsamba, B., Sousa, S. G.   +4 more
core   +1 more source

The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding [PDF]

, 2013
The validity of the identification and classification of human cancer using antibodies to detect biomarker proteins depends upon antibody specificity. Antibodies that bind to the tumour-suppressor protein p16INK4a are widely used for cancer diagnosis and
A Melck, A Okamoto, AM Groeger, BC Soares de Sa, BE Gould Rotheberg, C Michaloglou, C Pilon, CQ Zhu, David Andrew Gunn, DE Marra, Dudley Ferdinando, F Haller, F Haller, G Volgareva, H Lin, HA McKenzie, Hong Wu, J Chen, J Lukas, Jeffrey Pawlikowski, JW Rocco, K Cuschieri, K Nilsson, M Dray, M Schutte, Magdalena Sawicka, Peter David Adams, R Klaes, S Pavey, Sophia N. Karagiannis, SS Wang, Stephen Wilson, WH Liggett Jr, William Parish, Y Cheng   +34 more
core   +3 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]

, 2016
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA, Clarke, J, Eliceiri, KW, Ford, K, Frampton, S, Garcia, E, Gil, J, Hanley, CJ, Herranz, N, Kabir, TD, King, EV, Lambert, DW, Lim, KP, Mellone, M, Mellows, T, Moutasim, KA, Ottensmeier, CH, Prime, SS, Thirdborough, S, Thomas, GJ, Tod, J, Underwood, TJ, Venei, V, Venturi, G, Vijayanand, P, Woelk, C, Woo, J   +26 more
core   +3 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Inhibition of Breast Tumor Cell Growth by Ectopic Expression of p16/INK4A Via Combined Effects of Cell Cycle Arrest, Senescence and Apoptotic Induction, and Angiogenesis Inhibition

Journal of Cancer, 2012
p16-mediated inhibition of cancer cell proliferation and tumor suppression have been studied before,; the common consensus is that p16's cell-cycle arrest function plays a primary role in these actions, with some additional apoptotic induction by p16 ...
Yi Lu, Xiongwen Zhang, Jun Zhang
doaj  

Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts

Chinese Medical Journal
. Background:. P16 inactivation is frequently accompanied by telomerase reverse transcriptase (TERT) amplification in human cancer genomes. P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cells by TERT ...
Xuehong Zhang, Paiyun Li, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang, Dajun Deng, Jing Ni   +10 more
doaj   +1 more source

Atorvastatin treatment modulates p16 promoter methylation to regulate p16 expression [PDF]

The FEBS Journal, 2017
Intimal hyperplasia, the key event of arterial restenosis, is a result of cell proliferation and cell migration. Atorvastatin exerts an inhibitory effect on cell proliferation and migration, but the mechanism remains largely unknown. p16, as a well‐known tumor suppressor, was also reported to suppress cell growth and migration, but with an unclear ...
Boqian, Zhu, Yaoyao, Gong, Gaoliang, Yan, Dong, Wang, Qingjie, Wang, Yong, Qiao, Jiantong, Hou, Bo, Liu, Chengchun, Tang   +8 more
openaire   +2 more sources

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Loss of P16 in Esophageal Adenocarcinoma Detected by Fluorescence in situ Hybridization and Immunohistochemistry

Acta Medica Bulgarica, 2017
Molecular biology of esophageal adenocarcinoma (EAC) is not fully elucidated. The aim of this study was to assess the expression of cycle regulator and tumor suppressor p16 in esophageal adenocarcinoma. The expression of p16 at protein and gene level was
Kotzev A., Kamenova M.
doaj   +1 more source