Results 81 to 90 of about 89,060 (300)

Induction of the Tumor-Suppressor p16INK4a within Regenerative Epithelial Crypts in Ulcerative Colitis

Neoplasia: An International Journal for Oncology Research, 2006
p16INK4a is a major tumor-suppressor protein, but its regulation and settings of fuction remain poorly understood. To explore the notion that p16 is induced in vivo in response to replicative stress, we examined p16 expression in tissues from human ...
Emma E. Furth, Karen S. Gustafson, Charlotte Y. Dai, Steven L. Gibson, Paul Menard-Katcher, Tina Chen, Jim Koh, Greg H. Enders   +7 more
doaj   +1 more source

Differential impact of p16 inactivation by promoter methylation in non-small cell lung and colorectal cancer: Clinical implications

, 2004
Inactivation of p16 has been reported as one of the more frequent events in human carcinogenesis. In order to contribute to the knowledge of the impact of p16 silencing by promoter methylation, we have investigated p16 expression and inactivation of p16 ...
Morán, Alberto, González-Quevedo, Rosa, Benito De Las Heras, Manuel R., Pilar Iniesta, Sánchez Pernaute, Andrés, Balibrea Cantero, José Luis, García-Aranda, Cristina, Juan Chocano, María Del Carmen De, Díaz-Rubio García, Eduardo, Iniesta Serrano, María Pilar, Torres García, Antonio José   +10 more
core   +1 more source

Genomic characterization of p16+ compared to p16- HNSCC patients treated with immune checkpoint inhibitors and overall survival

, 2021
e18024 Background: Multiple studies investigating immune checkpoint inhibitors (ICI) in head and neck squamous cell cancer (HNSCC) patients have demonstrated prolonged survival of p16+ versus p16- tumors. However, the data has been conflicting.
Hughes, Brittany Nicole, Nabhan, Chadi, Grover, Punita, McGrath, Julie Elaine, Chernock, Rebecca, Sukari, Ammar, Shaikh, Hira Ghazal, Ikpeazu, Chukwuemeka, Wise-Draper, Trisha Michel, Darabi, Sourat, Xiu, Joanne, Korn, Wolfgang Michael   +11 more
core   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16^INK4a

Molecular Cancer, 2009
Background CDKN2A/p16INK4a is frequently altered in human cancers and it is the most important melanoma susceptibility gene identified to date. p16INK4a inhibits pRb phosphorylation and induces cell cycle arrest, which is considered its main tumour ...
Mann Graham J, Reisman David N, Scolyer Richard A, Diefenbach Eve, Frausto Monika, Scurr Lyndee L, Dijkstra Menno K, Haferkamp Sebastian, Becker Therese M, Kefford Richard F, Rizos Helen   +10 more
doaj   +1 more source

Expression of p16 protein in breast cancer

Breast cancer is the most common cancer and a leading cause of death in women in Saudi Arabia. P16 is a tumour suppressor gene that plays a crucial role in regulating cell cycle.
Saad Samargandy, Mehenaz Hanbazazh, Jaudah Al-Maghrabi, Abdulhadi Samman   +3 more
core   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

p16^INK4a hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell Carcinoma

BMC Cancer, 2010
Background Tumor suppressor genes p53 and p16INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis.
Memar Bahram, Moaven Omeed, Malekzadeh Reza, Khademi Hooman, Sotoudeh Masoud, Biramijamal Firouzeh, Taghavi Noushin, A'rabi Azadeh, Abbaszadegan Mohammad   +8 more
doaj   +1 more source

CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels

Frontiers in Cell and Developmental Biology, 2020
The lipid-storage hepatic stellate cells (HSC) play as pivotal role in liver fibrosis being able to trans-differentiate into myofibroblasts in response to various pro-fibrogenic stimuli.
Fangqiao Lv, Nan Li, Ming Kong, Jun Wu, Zhiwen Fan, Dengshun Miao, Yong Xu, Yong Xu, Qing Ye, Yutong Wang   +9 more
doaj   +1 more source