Results 91 to 100 of about 89,060 (300)

p16 enhances HCC cell migration.

, 2013
(A) Upper panel: Immunoblot confirming ectopic p16 expression in MM189 and BL322 mouse HCC cells infected with either pBabe-puro retrovirus (Vector control, VC) or pBabe-puro retrovirus encoding wild type p16 (p16).
Hsiao-Chien Chu (142299), David S. Klimstra (316768), Brian C. Lewis (142308), Wei-Jyh Shiah (436893), Ya-Wen Chen (142312), Ze-Shiang Lin (142294), Chen-Pin Chou (436894)   +6 more
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Identification and characterization of a homozygous deletion found in ovarian ascites by representational difference analysis

, 1999
We have performed representational difference analysis (RDA) on DNA from tumor cells and normal fibroblasts isolated from the ascites of a patient with ovarian cancer. Five of six products of the RDA were homozygously deleted from the tumor DNA.
Perry, P, Morrison, H, Gabra, H, Taylor, K J, Watson, J E, Porteous, D J, Rabiasz, G J, Smyth, J F   +7 more
core  

ABCB5 and the regulation of p16INK4a by non-coding RNA [PDF]

, 2014
p16INK4a (p16) traps the cell at the restriction point of the cell cycle by binding to cyclin-dependent kinase 4/6 thus preventing the phosphorylation of the retinoblastoma protein (pRB).
Braker, Paul
core  

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Expression of Anion Exchanger 1 Sequestrates p16 in the Cytoplasm in Gastric, Colonic Adenocarcinoma

Neoplasia: An International Journal for Oncology Research, 2007
p16INK4A (p16) binds to cyclin-dependent kinase 4/6, negatively regulates cell growth. Recent studies have led to an understanding of additional biologic functions for p16; however, the detailed mechanisms involved are still elusive.
Wei-Wei Shen, Jun Wu, Li Cai, Bing-Ya Liu, Yan Gao, Guo-Qiang Chen, Guo-Hui Fu   +6 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Comparison of Modified Scarff-Bloom-Richardson Grading System with p16 and bcl-2 Expression in Invasive Ductal Carcinoma

, 2015
Aim: Breast cancer is the most frequent cancer among women. The p16INK4a and bcl-2 genes are the two major pathways involved in control of the cell cycle. They also play key roles in breast carcinogenesis.
Selma Erdoğan Düzcü, Mihriban Gürbüzel, Saime Gül Barut   +2 more
core   +1 more source

Deregulation of cell growth and apoptosis in UV-induced melanomagenesis

Frontiers in Bioscience-Elite, 2020
We have previously characterized the role of p16/Rb in coordinating the early events in UVB-irradiated skin. As an extension to this work, normal melanocytes and mutant p16-inducible melanoma cell models were employed to elucidate further the coordinated
Allal Ouhtit, Ishita Gupta, Rajiv L. Gaur, Augusta Fernando, Amira O. Abd El-Azim, Ali Eid, Therese M Becker   +6 more
doaj   +1 more source

Genome-wide overexpression screen identifies genes able to bypass p16-mediated senescence in melanoma [PDF]

, 2017
Malignant melanomas often arise from nevi, which result from initial oncogene-induced hyperproliferation of melanocytes that are maintained in a CDKN2A/p16-mediated senescent state.
Stevenson, Alexander J, Gonda, Thomas J., Gabrielli, Brian, Fox, Carly, Yaswen, Paul, Gonda, Thomas J, Stevenson, Alexander J., Skalamera, Dubravka, Ranall, Max V, Shakhbazov, Konstanin, Lambie, Duncan, Lee, Won Jae, Dahmer-Heath, Mareike, Ranall, Max V.   +13 more
core   +1 more source