Results 51 to 60 of about 212,746 (279)
High prevalence of p16 staining in malignant tumors.
PLoS ONE, 2022 p16 (CDKN2A) is a member of the INK4 class of cell cycle inhibitors, which is often dysregulated in cancer. However, the prevalence of p16 expression in different cancer types is controversial.
Noémi De Wispelaere +29 more
doaj +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
A search-based technique for testing from extended finite state machine model [PDF]
, 2009 Extended finite state machines (EFSMs), and languages such as state-charts that are similar to EFSMs, are widely used to model state-based systems. When testing from an EFSM M it is common to aim to produce a set of test sequences (input sequences) that ...
Hierons, RM, Kalaji, AS, Swift, S
core
On the fundamental group of the complement of a complex hyperplane arrangement
, 2015 We construct two combinatorially equivalent line arrangements in the complex projective plane such that the fundamental groups of their complements are not isomorphic.
D. J. A. Welsh +8 more
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Towards understanding the Planck thermal dust models
, 2017 Understanding the properties of dust emission in the microwave domain is an important premise for the next generation of cosmic microwave background (CMB) experiments, devoted to the measurement of the primordial $B$-modes of polarization. In this paper,
Liu, Hao +2 more
core +1 more source
Advanced Functional Materials, EarlyView.Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk +3 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao +20 more
wiley +1 more source
Immunostaining for the tumour suppressor gene p16 product is a useful marker to differentiate melanoma metastasis from lymph-node nevus [PDF]
, 2018 Upon the introduction of extensive sampling protocols of sentinel node biopsies, pathologists are increasingly confronted with small melanoma metastases.
Heitz, Philipp +3 more
core
A semi-analytic dynamical friction model for cored galaxies [PDF]
, 2016 We present a dynamical friction model based on Chandrasekhar's formula that reproduces the fast inspiral and stalling experienced by satellites orbiting galaxies with a large constant density core.
Gualandris, Alessia +2 more
core +2 more sources