Results 131 to 140 of about 217,248 (344)

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

P1–047: Elucidating the relationship between β2 adrenergic receptor, tau and mTOR [PDF]

, 2013
Elena V. Wisely, Salvatore Oddo
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Case report: CAR-T therapy demonstrated safety and efficacy in relapsed/refractory diffuse large B-cell lymphoma patients complicated with hepatitis B-related cirrhosis

Frontiers in Oncology
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated both efficacy and safety in relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients infected with hepatitis B virus (HBV).
Danqing Kong, Danqing Kong, Nana Ping, Nana Ping, Qian Zhu, Qian Zhu, Xiao Zhang, Xiao Zhang, Junhong Li, Junhong Li, Rui Zou, Depei Wu, Depei Wu, Zhengming Jin, Zhengming Jin, Changju Qu, Changju Qu   +16 more
doaj   +1 more source

Development of a Novel Fiber Optic Sensor Combined with a Fluorescence Turn-on Probe for Cu (II) Detection

E3S Web of Conferences, 2013
Existing staining-based methodology for the detection of metal ions is not well suited for real-time or in situ use. This is a significant problem, given that these ions can have a considerable impact on both human health and the environment. Thus, there
Ma J., Chiniforooshan Y., Hao W. H., Bock W.J., Wang Z. Y., Dabek-Zlotorzynska E.   +5 more
doaj   +1 more source

P1-193: Epidermal Growth Factor Receptor (EGFR) inhibition with gefitinib is synergistic with prostacyclin synthase overexpression in chemopreventing murine lung cancer [PDF]

, 2007
Anthony B. Mozer, Tyler M. Hudish, Mysan Le, Vijaya Karoor, York E. Miller, Robert L. Keith   +5 more
openalex   +1 more source

Automated Benchmarking of Variable‐Property Soft Robotic Fingertips to Enable Task‐Optimized Sensor Selection

Advanced Science, EarlyView.
Sensorized fingertips are needed to unlock robotic dexterity, versatility, and diverse interactions. Here, 15 identically‐shaped robotic fingertips are benchmarked by a fully automated toolchange system, covering eight different materials and six broadly‐ranging sensing mechanisms.
David Hardman, Benhui Dai, Qinghua Guan, Antonia Georgopoulou, Fumiya Iida, Josie Hughes   +5 more
wiley   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

The Membrane-type Collectin CL-P1 Is a Scavenger Receptor on Vascular Endothelial Cells [PDF]

, 2001
Katsuki Ohtani, Yasuhiko Suzuki, Souji Eda, Takao Kawai, Tetsuo Kase, Hiroyuki Keshi, Yoshinori Sakai, Atsushi Fukuoh, Takashi Sakamoto, Hiroyuki Itabe, Tatsuo Suzutani, Masahiro Ogasawara, Itsuro Yoshida, Nobutaka Wakamiya   +13 more
openalex   +1 more source

Diffusive Mobile Molecular Communications Over Time-Variant Channels

, 2017
This letter introduces a formalism for modeling time-variant channels for diffusive molecular communication systems. In particular, we consider a fluid environment where one transmitter nano-machine and one receiver nano-machine are subjected to Brownian
Ahmadzadeh, Arman, Jamali, Vahid, Noel, Adam, Schober, Robert   +3 more
core   +1 more source