Results 151 to 160 of about 99,821 (298)

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

open access: yesArthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen   +23 more
wiley   +1 more source

Adenosine Signaling in Primary and Metastatic Brain Tumors: Immune Suppression, Tumor Progression, and Therapeutic Opportunities. [PDF]

open access: yesMol Neurobiol
de Oliveira Lima T   +10 more
europepmc   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

open access: yesArthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel   +12 more
wiley   +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez   +295 more
wiley   +1 more source

VP1-141 is a determinant of a Vero cell-adapted Coxsackievirus A10 for vaccine development. [PDF]

open access: yesPLoS Negl Trop Dis
Chen CH   +5 more
europepmc   +1 more source

Game‐based learning for undergraduate consolidation: A qualitative study of how game‐based learning provides much more than knowledge acquisition

open access: yesAnatomical Sciences Education, Volume 19, Issue 6, Page 810-821, June 2026.
Abstract Game‐based learning (GBL) is increasingly used in medical education to supplement traditional didactic learning methods. Adult learners in particular may benefit from GBL, given the autonomous and iterative nature of a well‐designed educational game.
Thomas J. Paddock, Erin P. Fillmore
wiley   +1 more source

A1 ADENOSINE RECEPTOR REGULATES ATP-MEDIATED MICROGLIAL ACTIVATION IN VIVO AND IN VITRO: ROLE IN THE SPINAL NEURONAL PLASTICITY IN NEUROPATHIC MICE

open access: yes, 2013
Microglia are central nervous system (CNS) resident cells that sense pathological tissue alterations. Several microglia functions are governed by the purinergic system due to the presence on these cells of P1 and P2 (P2X, P2Y) receptors for adenosine and
L. Gatta   +14 more
core  

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