Results 151 to 160 of about 97,940 (264)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Advances in cancer immunotherapy: adoptive cell therapy and immune cell engagers in solid tumours. [PDF]

Br J Cancer
Panasci J, Park CL, Tran B, Siu LL.
europepmc   +1 more source

‘Giving Back to Our Community’: The Retention of the Aboriginal and Torres Strait Islander Disability Workforce in New South Wales, Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT The Aboriginal and Torres Strait Islander people of Australia require culturally responsive services. The Australian government has committed to establishing strategies to increase the size of the Aboriginal and Torres Strait Islander disability workforce; however, there is scant research on the factors influencing retention.
J. Gwynn, J. Gilroy, S. Peter, F. Talbot, K. Bulkeley, C. Alcorso, K. Gwynne, B. Rambaldini, A. Haines, M. Lincoln   +9 more
wiley   +1 more source

A single residue in the VP3 capsid protein governs virulence and informs live-attenuated vaccine design for coxsackievirus A6. [PDF]

J Virol
Liu K, Liu Z, Yan X, Yang Z, Li X, Zhang C.   +5 more
europepmc   +1 more source

Expectations and Reality: The Lived Experiences of Australians With Psychosocial Disability Within the NDIS

Australian Journal of Social Issues, EarlyView.
ABSTRACT While Australia's National Disability Insurance Scheme (NDIS) was founded on principles of choice and control, for people with significant mental health challenges (what the NDIS calls ‘psychosocial disability’) these ideals often remain elusive. Support systems continue to be fractured and in the context of ongoing policy reforms, it is vital
Joel Hollier, Jennifer Smith‐Merry
wiley   +1 more source

Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2). [PDF]

J Exp Med
Gruber C, Ramba M, Debnath B, Cuollo L, Neehus AL, Lee A, Buta S, Martin-Fernandez M, Rosain J, Berteloot L, Drabent P, Le Voyer T, Soudée C, Peel J, Seeleuthner Y, Puel A, Zhang SY, Ciancanelli MJ, Arango-Franco CA, Migaud M, Frémond ML, Renaldo F, Boespflug-Tanguy O, Dorboz I, Dubern B, Fonteneau T, Parvaneh N, Molatefi R, Shahrooei M, Duffy D, Bondet V, Rice GI, Crow YJ, Molina TJ, Boddaert N, Casanova JL, Houdouin V, Melki I, Hadchouel A, Bustamante J, Bogunovic D.   +40 more
europepmc   +1 more source

Australian Practitioners' Beliefs, Confidence, and Training Needs for Delivering Behaviour Support to Children and Young People in Out‐of‐Home Care

Australian Journal of Social Issues, EarlyView.
ABSTRACT Children in out‐of‐home care (OOHC) frequently present with complex behavioural needs. In New South Wales (NSW), behaviour support plans (BSPs) are mandated when restrictive practices, including psychotropic medication, are used. Little research has examined whether the statutory workforce is adequately prepared to meet behaviour support ...
Manisha Abayakoon Stanborough, Kelly‐Ann Allen, Emily Berger, Mikaela Stanborough, Erin Leif   +4 more
wiley   +1 more source

Complications after medullary thyroid carcinoma surgery: multicentre study of the SQRTPA and EUROCRINE® databases

BJS (British Journal of Surgery), EarlyView., 2020
This study investigated postoperative complications after surgery for medullary thyroid carcinoma (MTC) in Europe. Hypoparathyroidism, recurrent laryngeal nerve palsy and bleeding requiring reoperation occurred in 170 (26·2 per cent), 62 (13·7 per cent) and 17 (2·6 per cent) patients respectively.
D.‐J. van Beek, M. Almquist, A. O. Bergenfelz, T. J. Musholt, E. Nordenström, on behalf of the EUROCRINE® Council, M. Almquist, M. Barczynski, L. Brunaud, T. Clerici, M. H. Hansen, M. Iacobone, Ö. Makay, F. F. Palazzo, N. Muñoz‐Pérez, M. Raffaelli, P. Riss, S. van Slycke, M. R. Vriens   +18 more
wiley   +1 more source

Mouse Lacrimal Gland Ductal Organoids With Controlled Polarity: A Novel Ex Vivo Research Model. [PDF]

Invest Ophthalmol Vis Sci
Csapó V, Elekes G, Tálosi D, Török D, Bellák T, Tóth-Molnár E.   +5 more
europepmc   +1 more source

Aberrant intra-epithelial lymphocytes cause enterocyte cell death in refractory celiac disease by CD103-β7-receptor-mediated granzyme-B degranulation which can be restored by etrolizumab. [PDF]

Clin Transl Immunology
Castelijn DAR, van de Water JMW, de Baaij LR, McGlinchy BS, van Leeuwen M, Joosten SPJ, Alberts N, Rossi M, Reijm M, Hollander JC, Bonnet P, Kooy-Winkelaar YMC, Koning F, Pals ST, Bouma G, Meijer CJLM, Bontkes HJ, Mulder CJJ, Cillessen SAGM.   +18 more
europepmc   +1 more source