Results 191 to 200 of about 1,469,677 (296)

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Functional Repurposing of Magnetic Nanoparticle-Assisted Hyperthermia for Immune Cell Labelling and Tracking. [PDF]

Small Methods
Nucci GEP, Vitale C, Girolamo AD, Silvestri N, Persano S, Gjurgjaj L, Bottino C, Castriconi R, Pellegrino T.   +8 more
europepmc   +1 more source

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Annals of Neurology, EarlyView.
Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified.
Ionuț‐Flavius Bratu, Isabelle Lambert, Olivier Felician, Samuel Medina Villalon, Agnès Trébuchon, Fabrice Bartolomei   +5 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Investigating the fruitless-directed molecular and circuit architecture of courtship behavior in Drosophila melanogaster, Drosophila simulans, and their hybrids. [PDF]

Genetics
Palmateer CM, Morris KC, Nolting S, Mast J, Arbeitman MN.   +4 more
europepmc   +1 more source

Discovery of Small-Molecule GLP‑1 Receptor Agonists with Improved Oral Pharmacokinetics Based on Orforglipron. [PDF]

ACS Med Chem Lett
Li M, Fang J, Qi G, Guo S, Xu T, Lu Y, Yuan Q, Wang J, Zhu S, Shen J, Yang H, Xie X, Wang K.   +12 more
europepmc   +1 more source

OBSERVATIONS ON THE BLOOD GROUP RECEPTOR P1 AND ITS DEVELOPMENT IN CHILDREN [PDF]

Hereditas, 2009
openaire   +1 more source

Adenosine Signaling in Primary and Metastatic Brain Tumors: Immune Suppression, Tumor Progression, and Therapeutic Opportunities. [PDF]

Mol Neurobiol
de Oliveira Lima T, Soares AA, Böhm BR, Teixeira BM, da Costa LCT, Pretto KP, de Souza JVG, da Cunha MLV, Lameu C, Boison D, de Resende eSilva DT.   +10 more
europepmc   +1 more source

Synergistic effects of two bacteriophages with distinct infection patterns and broad host specificity against multidrug-resistant Salmonella Typhimurium and their potential applications in the poultry industry. [PDF]

Poult Sci
Choi Y, Park J, Kang A, Seo E, Lee DJ, Son SH, Jang KB, Kim WK, Kang D, Kim Y.   +9 more
europepmc   +1 more source

Characterization of muscarinic receptor in guinea pig uterus smooth muscle

, 1991
(), Doods, H. N. (Author), Willim, K. (Author), Krause, J. (Author)   +3 more
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