Results 201 to 210 of about 117,126 (251)

P1 Receptors in the Cardiovascular System

2001
The presence of adenosine receptors on cardiovascular tissues has previously been established on the basis of functional responses to adenosine and adenosine analogs. Specific functions attributed to each of the four adenosine receptor subtypes (A1, A2A, A2B, and A3) are discussed in detail below following a summary of the direct evidence for adenosine
R.M. Broad, Joel Linden
openaire   +1 more source

P1 Receptors in the Respiratory System

2001
In this chapter the role of adenosine receptors in the modulation respiratory system is reviewed. The chapter is divided into sections based on the effects of adenosine receptors on the different aspects of pulmonary physiology. The potential role of PI purinergic receptors in the regulation of epithelial and endothelial function, ventilatory drive ...
I. Biaggioni, I. Feoktistov
openaire   +1 more source

Impact of Ectoenzymes on P2 and P1 Receptor Signaling

2011
P2 receptors that are activated by extracellular nucleotides (e.g., ATP, ADP, UTP, UDP, Ap(n)A) and P1 receptors activated by adenosine control a diversity of biological processes. The activation of these receptors is tightly regulated by ectoenzymes that metabolize their ligands.
Filip, Kukulski, Sébastien A, Lévesque, Jean, Sévigny   +2 more
openaire   +2 more sources

Modulating P1 Adenosine Receptors in Disease Progression of SOD1G93A Mutant Mice

Neurochemical Research, 2019
Amyotrophic lateral sclerosis (ALS) is a fatal progressing neurodegenerative disease; to date, despite the intense research effort, only two therapeutic options, with very limited effects, are available. The purinergic system has been indicated as a possible new therapeutic target for ALS, but the results are often contradictory and generally confused.
Monica Armida, Alessandra Matteucci, Antonella Pèzzola, Younis Baqi, Christa E. Müller, Patrizia Popoli, Rosa Luisa Potenza   +6 more
openaire   +2 more sources

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

Glia, 2012
AbstractMicroglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic “modal shifts”, purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y12 receptors, they are transformed into a moving phenotype, showing process extension and migration ...
Schuichi, Koizumi, Keiko, Ohsawa, Kazuhide, Inoue, Shinichi, Kohsaka   +3 more
openaire   +2 more sources

P1 and P2 Purine and Pyrimidine Receptor Ligands

2001
Research focused on P1 and P2 purinergic receptor function is currently at a critical stage where considerable efforts in the disciplines of medicinal chemistry, molecular biology, and pharmacology have resulted in the identification of a number of novel ligands that have been used to enhance understanding of the roles of both P1 (adenosine) and P2 ...
K. A. Jacobson, L. J. S. Knutsen
openaire   +1 more source

Abstract P1-07-09: Estrogen receptor positivity: 10% or 1%?

Cancer Research, 2012
Abstract Background. Guidelines by the American Society of Clinical Oncology and the College of American Pathologists recently recommended that estrogen receptor (ER) status should be considered positive if 1% of tumor cells demonstrate positive nuclear staining by immunohistochemistry.
M Yi, L Huo, KB Koenig, EA Mittendorf, F Meric-Bernstam, HM Kuerer, I Bedrosian, WF Symmans, GN Hortobagyi, JR Crow, RR Shah, KK Hunt   +11 more
openaire   +1 more source

P1 and P2 Receptors in Platelets

2001
Because of the importance of platelets in haemostasis and thrombosis, these cell fragments have been extensively studied for many years and the existence of receptors for adenosine and adenine nucleotides on platelets has been recognised since the early 1960s.
openaire   +1 more source

P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes

Journal of Applied Physiology, 1989
Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas the EC50 for ADP, AMP, adenosine, and the nonmetabolizable ATP analogue alpha,beta-methylene ATP ...
D, Warburton, S, Buckley, L, Cosico
openaire   +2 more sources

Abstract P1-05-03: Isoform specific targeting of insulin receptor

Cancer Research, 2019
Abstract The insulin receptor (InsR) exists in both an A and B isoform. InsR-B differs from InsR-A by the inclusion of exon 11, which encodes 12 amino acid residues at the C-terminus of the InsR alpha-subunit. Increased InsR-A expression is associated with mitogenic signaling pathways while InsR-B is linked to insulin-mediated metabolic ...
K LaPara, JY Chan, A Zdechlik, K Ljunggren, D Schmidt, B Hackel, D Yee   +6 more
openaire   +1 more source