Results 221 to 230 of about 97,940 (264)
Some of the next articles are maybe not open access.
Modulating P1 Adenosine Receptors in Disease Progression of SOD1G93A Mutant Mice
Neurochemical Research, 2019Amyotrophic lateral sclerosis (ALS) is a fatal progressing neurodegenerative disease; to date, despite the intense research effort, only two therapeutic options, with very limited effects, are available. The purinergic system has been indicated as a possible new therapeutic target for ALS, but the results are often contradictory and generally confused.
Monica Armida +6 more
openaire +2 more sources
P1 and P2 Receptors in Platelets
2001Because of the importance of platelets in haemostasis and thrombosis, these cell fragments have been extensively studied for many years and the existence of receptors for adenosine and adenine nucleotides on platelets has been recognised since the early 1960s.
openaire +1 more source
P1 and P2 receptors in cell growth and differentiation
Drug Development Research, 1996Besides their well-established roles as short-term neurotransmitters, nucleotides and nucleosides are also potent regulators of cell growth and differentiation. Compelling evidence obtained on neural, immune, cardiovascular and respiratory system cells, as well as on many other cell types, suggests that these compounds may act as physiological ...
openaire +2 more sources
Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.
International Journal of Oncology, 2000Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. Recombinantly prepared soluble form of rat NKR-P1 (CD161) recognized carbohydrate GalNac and GlcNac moieties. Ganglioside GM2 and heparin related-IS oligosaccharides representing the high affinity ligands for this receptor, increased the ...
M, Pospisil +6 more
openaire +2 more sources
P1 and P2 Receptors in the Renal System
2001Modulation of the function of excretory organs by purine receptors is an ancient regulatory strategy adopted early in the course of vertebrate evolution. For instance, in the shark rectal gland, an excretory organ that evolved more than 400 million years ago, primordial adenosine receptors strongly influence the rate of sodium chloride transport and ...
openaire +1 more source
P1 Receptor Agonists/Antagonists in Clinical Trials - Potential Drug Candidates of the Future
Current Pharmaceutical Design, 2019Background:Adenosine mediates various physiological and pathological conditions by acting on its four P1 receptors (A1, A2A, A2B and A3 receptors). Omnipresence of P1 receptors and their activation, exert a wide range of biological activities. Thus, its modulation is implicated in various disorders like Parkinson’s disease, asthma, cardiovascular ...
Pobitra, Borah +3 more
openaire +2 more sources
P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes
Journal of Applied Physiology, 1989Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas the EC50 for ADP, AMP, adenosine, and the nonmetabolizable ATP analogue alpha,beta-methylene ATP ...
D, Warburton, S, Buckley, L, Cosico
openaire +2 more sources
Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly