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Results 221 to 230 of about 1,469,677 (296)

Cumulative Reproductive‐Lactation Burdens Induce a Systemic Immunometabolic Trade‐Off Between Milk Yield and Mammary Health of Dairy Cows

Animal Research and One Health, EarlyView.
A population‐scale longitudinal transcriptomic atlas reveals how lactation stage and parity reshape systemic gene regulation in dairy cows. Multiomics‐inspired analyses uncover dynamic immune and metabolic adaptations that contribute to reproductive longevity and sustained productivity across the bovine lifespan.
Yangyang Shen +8 more
wiley +1 more source

Association-Based Analysis of Verticillium Wilt Resistance in a Bi-Parental Hop (<i>Humulus lupulus</i> L.) Population for Marker Development in Breeding. [PDF]

Plants (Basel)
Luskar L +6 more
europepmc +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel +12 more
wiley +1 more source

Purified Compounds from <i>Phyllanthus amarus</i> Schum. & Thonn. Inhibit Mast Cell Degranulation via Modulation of Syk/PLCγ Signaling. [PDF]

Molecules
Vo TS, My VTN, Luan PVH, Ngo DH.
europepmc +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

Epigenetic Regulation of Sialyltransferase ST6GAL1 Drives Breast Tumor Heterogeneity. [PDF]

Cancers (Basel)
Maiti A +7 more
europepmc +1 more source

Cross-species transcriptomics identify mineralocorticoid receptor pathway overactivation as a central driver of ocular rosacea. [PDF]

Nat Commun
Zhu L +9 more
europepmc +1 more source

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda +5 more
wiley +1 more source

VP1-141 is a determinant of a Vero cell-adapted Coxsackievirus A10 for vaccine development. [PDF]

PLoS Negl Trop Dis
Chen CH +5 more
europepmc +1 more source

Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations

Arthritis &Rheumatology, Accepted Article.
Objectives Sjögren's disease (SjD) is a heterogeneous autoimmune disorder characterized by substantial clinical and molecular diversity. This heterogeneity raises key questions regarding the existence of distinct pathogenic mechanisms underlying disease subtypes.
Geoffrey Urbanski +15 more
wiley +1 more source

3. good health
animals
adenosine

receptors, purinergic p1
humans
receptors, purinergic p2

medicine
purinergic p1 receptor agonists
atp