Results 111 to 120 of about 481,863 (320)

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Previous studies have demonstrated that p21 occupies a central position in cell-cycle regulation and DNA damage responses. As an unstable protein, the regulation of p21 stability has been extensively investigated over the past 20 years ...
Tanggang Deng, G. Yan, Xin Song, Lin Xie, Yu Zhou, Jianglin Li, Xiaoxiao Hu, Zhen Li, Jun Hu, Yibin Zhang, Hui Zhang, Yang Sun, Peifu Feng, Dong Wei, Bin Hu, Jing Liu, W. Tan, Mao Ye   +17 more
semanticscholar   +1 more source

A Programmable Semiconductor Containing Active Molecular Photoswitches Located in the Crystal's Volume Phase

Advanced Functional Materials, EarlyView.
A novel approach for the design of functional semiconductors is presented, which utilizes the excellent optoelectronic properties of layered hybrid perovskites and the possibility to introduce a molecular photoswitch as the organic spacer. This concept is successfully demonstrated on a coumarin‐based system with the possibility to change the bandgap ...
Oliver Treske, Yaşar Krysiak, Hans Tornatzky, Markus R. Wagner, Sebastian Polarz   +4 more
wiley   +1 more source

Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

Cell Death and Disease, 2017
Hepatocellular carcinoma (HCC) is characterized by a poor prognosis and is one of the leading causes of cancer-related death worldwide. Simvastatin, an HMG-CoA reductase inhibitor, which decreases cholesterol synthesis by inhibiting mevalonate pathways ...
Sin-Ting Wang, H. Ho, Jaw-Town Lin, J. Shieh, Chun-Ying Wu   +4 more
semanticscholar   +1 more source

Targeting p21 Degradation Locally [PDF]

Developmental Cell, 2010
Just as the activity of many multifunctional proteins is restricted by subcellular localization, so is their regulation. In this issue of Development Cell, Starostina et al. identify an E3 ubiquitin ligase, CRL2(LRR1), for the cyclin-dependent kinase inhibitor p21 that specifically ubiquitylates cytoplasmic p21 to facilitate cell migration.
openaire   +2 more sources

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, EarlyView.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source

Control of the Restriction Point by Rb and p21

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The canonical Restriction Point model suggests that cells are born into a state in which they are uncommitted to the cell cycle, but will activate cyclin-dependent kinase 2 and cross the Restriction Point several hours later if sufficient ...
Justin Moser, Iain Miller, Dylan Carter, S. Spencer   +3 more
semanticscholar   +1 more source

Testing CPT Symmetry with Supernova Neutrinos

, 2005
Diagnosing core of supernova requires favor-dependent reconstruction of three species of neutrino spectra, \nu_e, \bar{\nu}_{e} and \nu_x (a collective notation for \nu_{\mu}, \bar{\nu}_{\mu}, \nu_{\tau}, and \bar{\nu}_{\tau}).
B. Pontecorvo, B. Pontecorvo, C. Saji, G. Barenboim, Hisakazu Minakata, S. Weinberg, S. P. Mikheyev, S. P. Mikheyev, S. P. Mikheyev, Shoichi Uchinami, Z. Maki   +10 more
core   +1 more source

Where Most Frameworks Degrade: Flexible Bimetallic Phosphonate Crystals as pH‐Universal Supercapacitor Electrodes

Advanced Functional Materials, EarlyView.
Plastically flexible single crystals of the bimetallic phosphonate framework [Cu(2,2′‐bpy)VO(O3PC6H5)2] combine mechanical adaptability with robust pseudocapacitive charge storage. The material delivers about 140 Fg−1 at pH 4 and pH 10 and remains stable across pH 2‐12, enabling energy storage under comparatively mild electrolyte conditions.
Tim Müller, Jean G. A. Ruthes, Biswajit Battacharya, Dorothee Silbernagl, Patrik Tholen, Aysenur Limon, Gülsüm Kinik, Christoph Janiak, Markus Suta, Franziska Emmerling, Volker Presser, Gündoğ Yücesan   +11 more
wiley   +1 more source

A screen for inducers of p21waf1/cip1 identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties

Neurobiology of Disease, 2013
Preventing neuronal death is a priority for treating neurological diseases. However, therapies that inhibit pathological neuron loss could promote tumorigenesis by preventing the physiological death of cancerous cells.
Thong C. Ma, Brett Langley, Brian Ko, Na Wei, Irina G. Gazaryan, Neela Zareen, Darrell J. Yamashiro, Dianna E. Willis, Rajiv R. Ratan   +8 more
doaj   +1 more source

A lincRNA-p21/miR-181 family feedback loop regulates microglial activation during systemic LPS- and MPTP- induced neuroinflammation

Cell Death and Disease, 2018
The role of microglial-mediated sustained neuroinflammation in the onset and progression of Parkinson’s disease (PD) is well established, but the mechanisms contributing to microglial activation remain unclear. LincRNA-p21, a well studied long intergenic
Yongyi Ye, Xiaozheng He, Feng-fei Lu, Hengxu Mao, Zhiyuan Zhu, Longping Yao, Wanxian Luo, Xiang Sun, Baoyan Wang, Chen Qian, Yizhou Zhang, Guohui Lu, Shizhong Zhang   +12 more
semanticscholar   +1 more source