Results 91 to 100 of about 398,988 (295)

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Cyclin kinase inhibitor p21: a mediator of immune tolerance: direct and indirect evidence [PDF]

, 2009
*Background:* Uncontrolled proliferation of T-cells is considered a barrier to the induction of transplantation tolerance by T regulatory cells. Therefore, cyclin kinase inhibitor p21, one of the most potent inhibitors of cell proliferation, may exert an
Ashwani Khanna
core   +1 more source

Three-gluon vertex in arbitrary gauge and dimension [PDF]

, 1995
One-loop off-shell contributions to the three-gluon vertex are calculated, in arbitrary covariant gauge and in arbitrary space-time dimension, including quark-loop contributions (with massless quarks).
A. A. Abrikosov, A. Andras̆i, A. C. Hearn, A. I. Davydychev, A. I. Davydychev, A. I. Davydychev, A. I. Davydychev, A. I. Davydychev, A. Kizilersü, A. P. Prudnikov, A. T. Suzuki, B. A. Arbuzov, B. R. Webber, B. W. Harris, C. Ford, C. G. Bollini, C. Itzykson, C. Parrinello, D. Decamp, D. J. Broadhurst, D. J. Gross, D. Z. Friedman, E. Abdalla, E. Bagan, E. Braaten, E. E. Boos, E. E. Boos, E. E. Boos, F. T. Brandt, F. V. Tkachov, G. 't Hooft, G. 't Hooft, G. Källen, G. Mahlon, G. Passarino, H. C. Lee, H. D. Politzer, H. Fritzsch, H. M. Fried, I. Vendramin, J. J. van der Bij, J. M. Cornwall, J. S. Ball, J. S. Ball, J. S. Ball, K. G. Chetyrkin, L. D. Soloviev, L. Dixon, L. M. Brown, L. V. Dung, M. A. Nowak, M. D'Eramo, M. Dalbosco, M. Teper, N. I. Ussyukina, N. I. Ussyukina, N. I. Ussyukina, N. I. Ussyukina, O. V. Tarasov, P. Abreu, P. Osland, P. Pascual, P. Pascual, R. Akers, R. Brock, S. Bethke, S. K. Kim, S. Weinberg, T. Muta, W. A. Bardeen, W. Beenakker, W. Celmaster, W. Marciano, W. T. Giele, Z. Bern, Z. Bern, Z. Kunszt   +76 more
core   +5 more sources

Targeting p21 Degradation Locally [PDF]

Developmental Cell, 2010
Just as the activity of many multifunctional proteins is restricted by subcellular localization, so is their regulation. In this issue of Development Cell, Starostina et al. identify an E3 ubiquitin ligase, CRL2(LRR1), for the cyclin-dependent kinase inhibitor p21 that specifically ubiquitylates cytoplasmic p21 to facilitate cell migration.
openaire   +2 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

A screen for inducers of p21waf1/cip1 identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties

Neurobiology of Disease, 2013
Preventing neuronal death is a priority for treating neurological diseases. However, therapies that inhibit pathological neuron loss could promote tumorigenesis by preventing the physiological death of cancerous cells.
Thong C. Ma, Brett Langley, Brian Ko, Na Wei, Irina G. Gazaryan, Neela Zareen, Darrell J. Yamashiro, Dianna E. Willis, Rajiv R. Ratan   +8 more
doaj   +1 more source

Klein's programme and Quantum Mechanics

, 2015
We review the geometrical formulation of Quantum Mechanics to identify, according to Klein's programme, the corresponding group of transformations. For closed systems, it is the unitary group.
Clemente-Gallardo, J., Marmo, G.
core   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Nexrutine Inhibits Cancer Cell Growth as a Consequence of Mitochondrial Damage and Mitophagy

Cellular Physiology and Biochemistry, 2015
Background/Aims: Nexrutine is an herbal extract of Phellodendron amurense and has been used as nutrient supplement in China as well as America. Potential protection effect of Nexrutine has been reported. Methods: To investigate the mechanism of Nexrutine,
Xiang Wu, Shao-ming Zhou, Yi-Ling Ding, Ying-ping Gong, Weiqi Zeng, Yi Cui   +5 more
doaj   +1 more source

Vitamin C Promotes Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Oral squamous cell carcinoma (OSCC) is currently ranked as the eighth most prevalent type of cancer. Despite recent advances in cancer research, the 8-year survival rate for oral squamous cell carcinoma remains only 50–60%.
Jianjun Zhou, Chen Chen, Xiaoqing Chen, Yifan Fei, Lei Jiang, Guodong Wang   +5 more
doaj   +1 more source