Results 111 to 120 of about 398,988 (295)
Advanced Science, EarlyView.This study develops a novel 2D molecular ferroelectric [C6N2H18]PbI4 with polarization enhanced photovoltaics. It systematically investigates the effect of alkylamine spacer cation chain lengths on the band gap, ferroelectric, and photoelectric properties, offering new design strategies.
Ganghua Zhang +7 more
wiley +1 more source
Cells, 2018 Gene expression is often altered by epigenetic modifications that can significantly influence the growth ability and progression of cancers. SAHA (Suberoylanilide hydroxamic acid, also known as Vorinostat), a well-known Histone deacetylase (HDAC ...
Umamaheswari Natarajan +4 more
doaj +1 more source
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, EarlyView.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
eLife, 2014 The p53 transcription factor is a potent suppressor of tumor growth. We report here an analysis of its direct transcriptional program using Global Run-On sequencing (GRO-seq). Shortly after MDM2 inhibition by Nutlin-3, low levels of p53 rapidly activate ∼
Mary Ann Allen +11 more
doaj +1 more source
First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, EarlyView.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
Role of lncRNAs in Cellular Aging
Frontiers in Endocrinology, 2016 Aging is a universal, intrinsic and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism.
Lei Sun +3 more
doaj +1 more source
Bifurcation in cell cycle dynamics regulated by p53
, 2014 We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53.
Alam, Md. Jahoor +3 more
core +2 more sources
Advanced Science, EarlyView.Metal‐free molecular crystal [(CH3C6H10NH3)(18‐crown‐6)][ClO4] functions as a high‐performance molecular ferroelectric. Through strategic methylation of the cyclohexylamine unit, the compound achieves large spontaneous polarization and outstanding piezoelectric coefficients.
Nan Chen +4 more
wiley +1 more source
CITED1 promotes proliferation of papillary thyroid cancer cells via the regulation of p21 and p27
Cell & Bioscience, 2018 Background It has been reported that CBP/p300-Interacting Transactivator with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain 1 (CITED1) is overexpressed in papillary thyroid cancer (PTC).
Hai Li +9 more
doaj +1 more source
Robust and Tailored 1D/3D Heterojunction for Efficient and Stable Perovskite Solar Cells
Advanced Science, EarlyView.This study successfully established a robust 1D/3D heterojunction, characterized by a stable 1D phase, favorable lattice matching, strong interface binding, and effective defect passivation. The resulting epitaxial perovskite film demonstrates preferential vertical orientation of (100) facets, thereby facilitating carriers’ transport and stress relief.
Wending Hao +7 more
wiley +1 more source