Results 141 to 150 of about 398,988 (295)

Predicting and Rationalizing Piezoelectricity in Racemic Bioorganic Molecular Crystals

Angewandte Chemie, EarlyView.
Racemic molecular crystals, composed of equal mixtures of chiral enantiomeric components, are predicted to exhibit significant piezoelectric responses and favourable mechanical flexibility. This study identifies organic and bioorganic racemates as promising candidates for sustainable, lead‐free materials, enabling next‐generation applications in energy
Shubham Vishnoi, Sarah Guerin
wiley   +2 more sources

Expectations and Reality: The Lived Experiences of Australians With Psychosocial Disability Within the NDIS

Australian Journal of Social Issues, EarlyView.
ABSTRACT While Australia's National Disability Insurance Scheme (NDIS) was founded on principles of choice and control, for people with significant mental health challenges (what the NDIS calls ‘psychosocial disability’) these ideals often remain elusive. Support systems continue to be fractured and in the context of ongoing policy reforms, it is vital
Joel Hollier, Jennifer Smith‐Merry
wiley   +1 more source

Australian Practitioners' Beliefs, Confidence, and Training Needs for Delivering Behaviour Support to Children and Young People in Out‐of‐Home Care

Australian Journal of Social Issues, EarlyView.
ABSTRACT Children in out‐of‐home care (OOHC) frequently present with complex behavioural needs. In New South Wales (NSW), behaviour support plans (BSPs) are mandated when restrictive practices, including psychotropic medication, are used. Little research has examined whether the statutory workforce is adequately prepared to meet behaviour support ...
Manisha Abayakoon Stanborough, Kelly‐Ann Allen, Emily Berger, Mikaela Stanborough, Erin Leif   +4 more
wiley   +1 more source

Circularly Polarized Luminescent and Melt‐Processable Copper(I)‐Organic Glasses Based on 2,2′‐Bis(diphenylphosphino)‐1,1′‐binaphthyl

Angewandte Chemie, EarlyView.
Homochiral Cu(I) cyanide complexes based on 2,2’‐bis(diphenylphosphino)‐1,1’‐binaphthyl (BINAP) form melt‐quenched and desolvation‐derived metal–organic glasses that exhibit circularly polarized thermally activated delayed fluorescence (TADF) at room temperature, enabling processable chiroptical materials.
Zeyu Fan, Indranil Sen, Roman Pallach, Guo‐Qiang Li, Andreas Steffen, Sebastian Henke   +5 more
wiley   +2 more sources

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

Annals of Neurology, EarlyView.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral, Ana María Domínguez Cobo, Sol Balsells, Anna Aguilar‐Ros, Chu‐Ting Chang, William G. Ludlam, Kathryn Yang, Katerina Bernardi, Micaela Chinigioli, Ainara Salazar‐Villacorta, Veronica Di Pisa, Nuria Lamagrande‐Casanova, Elena González‐Alguacil, Beatriz De la Casa‐Fages, Akihisa Okumura, Josefina Rodríguez, Ayush Agarwal, Daniela Muñoz‐Chesta, Carolina Reynoso‐Osnayo, Amy Lin, Brahim Tabarki, Jobaida Parvin, Adolfo Alberto Gallo, Andreia Forno, Fabian Maass, Johnny Montiel Blanco, Salomé Nasif, Elizabeth Jennions, Jorge Luis Ramón‐Gómez, Helene Verhelst, Juan José Nieto Barceló, Dunja Čokolić Petrović, Luz Victoria García Ruiz, Christoph van Riesen, Paulo Rego Sousa, Maria del Pilar Massaro Sanchez, Husnea Ara Khan, Wejdan Hakami, Jennifer Friedman, Iván Espinoza‐Quinteros, Monica Troncoso, Divyani Garg, Micaela Pauni, Hirokazu Kurahashi, María Concepción Miranda‐Herrero, Anna Duat‐Rodriguez, Luca Soliani, Manju A. Kurian, Angeles Schteinschnaider, Siddharth Srivastava, Darius Ebrahimi‐Fakhari, Kirill A. Martemyanov, Juan Darío Ortigoza‐Escobar   +52 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Isolation und Reaktivtät eines quadratisch‐planaren Trisamidosilans

Angewandte Chemie, EarlyView.
Wir berichten über die Synthese und umfassende Charakterisierung eines quadratisch‐planaren Si(+IV)‐Hydrids, das von einem unsymmetrischen, trianionischen und dearomatisierten N,N,N‐Pincerliganden stabilisiert wird. Dieses System ermöglicht eine Element–Liganden‐kooperative Reaktivität als Alternative zur siliciumzentrierten Redoxchemie und erweitert ...
David M. J. Krengel, Xiaobai Wang, Christopher Golz, Regine Herbst‐Irmer, Oliver P. E. Townrow, Malte Fischer   +5 more
wiley   +1 more source

Dynamisch‐kovalente Radikalrekombination zur Assemblierung justierbarer responsiver poröser organischer Käfige

Angewandte Chemie, EarlyView.
Dynamisch‐kovalente Chemie (DCC) basierend auf reversibler Radikalrekombination ermöglicht die Assemblierung responsiver, C–C‐verknüpfter organischer Käfige. Substituentenkontrollierte Aryldicyanomethylradikale bilden diskrete, poröse Architekturen mit abstimmbarer Topologie aus Tri2‐ und Tri4‐Käfigen, Gasselektivität, Chromismus und ...
Yannic Hartmann, Robert Oestreich, Yuki Wada, Philippe de Bary, Masaki Kawano, Christoph Janiak, Bernd M. Schmidt   +6 more
wiley   +1 more source

Isolation and Reactivity of a Square‐Planar Trisamido Silane

Angewandte Chemie International Edition, EarlyView.
We report the synthesis and comprehensive characterisation of a square‐planar Si(+IV) hydride supported by an unsymmetric, trianionic and dearomatised N,N,N‐pincer ligand. This system enables element–ligand cooperative reactivity as an alternative to silicon‐centred redox chemistry, illuminating a largely unexplored regime in high‐valent silicon ...
David M. J. Krengel, Xiaobai Wang, Christopher Golz, Regine Herbst‐Irmer, Oliver P. E. Townrow, Malte Fischer   +5 more
wiley   +1 more source