Results 41 to 50 of about 398,988 (295)

HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis [PDF]

, 2009
Penile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis. In this study we examined cell-cycle proteins expression and correlation with human papillomavirus infection in a series of 15 pure penile verrucous ...
A Ouban, AL Cubilla, AL Cubilla, AL Cubilla, AL Cubilla, AL Cubilla, AL Seixas, AS Masih, AS Narayana, B Kleter, C Dianzani, C Missero, Catherine Corbishley, CB Bunker, CL Haycox, Daniel M Berney, David M Prowse, DE Johnson, DM Prowse, E Ferreux, EF Velazquez, Elena Ktori, Elzbieta Stankiewicz, FT Kraus, GD Higgins, IB Roninson, Jack Cuzick, JC Noel, JR Nevins, KH Cuesta, KW Chan, KY Lam, KY Lam, L Gregoire, Laurence Ambroisine, LC Cubilla, LH Sobin, LL Villa, LV Ackerman, M Gualco, M Senba, M Serrano, M Wong, MA Rubin, MR Cupp, MT Kiyabu, Nicholas Watkin, PA Adegboyega, PA Hall, PH McKee, S Pilotti, Sakunthala C Kudahetti, SL Harris, T Sano, TH Cheung, VA Tron, VA Varma, Xiaoxi Zhang, Y Koyamatsu   +58 more
core   +1 more source

rap1 p21 regulates the interaction of ras p21 with RGL, a new effector protein of ras p21 [PDF]

FEBS Letters, 1995
We have recently found that ralGDS family members (RGL and ralGDS) are putative effector proteins of ras p21. rap1 p21 is a small GTP‐binding protein which has the same amino acid sequence as the effector loop of ras p21. We examined the effect of rap1 p21 on the interaction of ras p21 with RGL.
Ikeda, Masahiro, Koyama, Shinya, Okazaki, Michiko, Dohi, Kiyohiko, Kikuchi, Akira   +4 more
openaire   +2 more sources

Canine Mammary Tumor Cell Lines Derived from Metastatic Foci Show Increased RAD51 Expression but Diminished Radioresistance via p21 Inhibition

Veterinary Sciences, 2022
Due to the high incidence of mammary tumors in dogs, it is important to elucidate the pathogenesis of these tumors in veterinary medicine. Radiation therapy is often used to treat mammary tumors that target DNA lesions.
Kei Shimakawa, Kazuhiko Ochiai, Sachi Hirose, Eri Tanabe, Masaki Michishita, Motoharu Sakaue, Yasunaga Yoshikawa, Masami Morimatsu, Tsuyoshi Tajima, Masami Watanabe, Yoshikazu Tanaka   +10 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An Experimental Study on Apoptosis of cultivated Wild Ginseng Distilled Herbal Acupuncture by Concentration Level

Journal of Pharmacopuncture, 2004
Objectives : In order to measure the efficacy of cultivated wild ginseng distilled herbal acupuncture by concentration level, we've treated A549 human lung cancer lines with different concentrations of cultivated wild ginseng distilled herbal acupuncture
Hee-Chul Cho, Sun-Gu Lee, Ki-Rok Kwon
doaj   +1 more source

Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Lmna Mutation

Frontiers in Cardiovascular Medicine, 2021
LMNA is one of the leading causative genes of genetically inherited dilated cardiomyopathy (DCM). Unlike most DCM-causative genes, which encode sarcomeric or sarcomere-related proteins, LMNA encodes nuclear envelope proteins, lamin A and C, and does not ...
Kenji Onoue, Kenji Onoue, Hiroko Wakimoto, Jiangming Jiang, Michael Parfenov, Steven DePalma, David Conner, Joshua Gorham, David McKean, Jonathan G. Seidman, Christine E. Seidman, Christine E. Seidman, Yoshihiko Saito   +12 more
doaj   +1 more source

Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]

, 1993
The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico, Goody, R. S., John, J., Rensland, H., Schlichting, I., Vetter, I., Wittinghofer, A.   +6 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Development of a Fish Cell Biosensor System for Genotoxicity Detection Based on DNA Damage-Induced Trans-Activation of p21 Gene Expression

Biosensors, 2012
p21CIP1/WAF1 is a p53-target gene in response to cellular DNA damage. Here we report the development of a fish cell biosensor system for high throughput genotoxicity detection of new drugs, by stably integrating two reporter plasmids of pGL3-p21-luc ...
Huarong Guo, Zhixia Zhang, Deyu Geng
doaj   +1 more source

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing [PDF]

, 2016
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could also be oncogenic, through a mechanism that has so far remained obscure.
A Duursma, A Viale, AB Niculescu, AC Bester, AC Porter, AJ Holland, Akshay K. Ahuja, Alexander Polyzos, Ana Igea, Angel Nebreda, Antonis Kokkalis, Apolinar Maya-Mendoza, B Langmead, Begoña Canovas, C Delehouzé, C Vaziri, CG Havens, Claus Storgaard Sørensen, CM Beauséjour, CZ Zhang, D Ottaviani, David Walter, Dimitris Kletsas, Dimitris Thanos, E Gibbs, E Petermann, EA Georgakopoulou, EK Benson, EK Papachristou, Emanuel Kanavakis, Emma J. Haagensen, ES Venkatraman, Fani-Marlen Roumelioti, FB Couch, G Velimezi, H Beck, H Li, H Nishitani, HA Sikder, HH Cha, I Iraqui, I Murfuni, IB Roninson, Igor B. Roninson, IS Pateras, J Bartkova, J Essers, J Pines, J Yu, J. Julian Blow, JCF de Winter, JH Barlow, Jiri Bartek, JJ Blow, JJ Blow, JR Rosai, JW Shay, K Chen, K Evangelou, K Hanada, KJ Neelsen, KJ Neelsen, KJ Neelsen, KJ Neelsen, Konstantinos Vougas, M Liontos, M Liontos, M Sideridou, M Terradas, Maria Tzetis, Massimo Lopes, MJ Peart, ML Agarwal, N Rivlin, NA Warfel, ND Perkins, P Karakaidos, Panagiotis Galanos, Paul Townsend, PJ Hastings, PJ Stephens, R Zellweger, RA Burrell, RA Woo, Ralph Zellweger, RH Ramirez-Gonzalez, S Bates, S Gonzalez, S Jørgensen, S Negrini, Sarantis Gagos, Sofia Havaki, Spiros D. Garbis, T Abbas, T Abbas, T Cooks, TD Halazonetis, TG Petrakis, Vassilis G. Gorgoulis, VG Gorgoulis, VN Budhavarapu, Y Wu   +101 more
core   +3 more sources