Results 31 to 40 of about 398,988 (295)

Ethanol Impairs NRF2/Antioxidant and Growth Signaling in the Intact Placenta In Vivo and in Human Trophoblasts

Biomolecules, 2019
NRF2 is a redox-sensitive transcription factor that depending on the duration or magnitude of the stress, either translocates to the nucleus (beneficial) or is degraded in the cytosol (harmful). However, the role of NRF2-based mechanism(s) under ethanol (
Sambantham Shanmugam, Dhyanesh Patel, John M. Wolpert, Caezaan Keshvani, Xiaobo Liu, Susan E. Bergeson, Srivatsan Kidambi, Lenin Mahimainathan, George I. Henderson, Madhusudhanan Narasimhan   +9 more
doaj   +1 more source

Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced ApoptosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: The intestinal epithelium must be resilient to physiochemical stress to uphold the physiological barrier separating the systemic compartment from the microbial and antigenic components of the gut lumen.
Alexandra A. Wolfarth, Xu Liu, Trevor M. Darby, Darra J. Boyer, Jocelyn B. Spizman, Joshua A. Owens, Bindu Chandrasekharan, Crystal R. Naudin, Krisztina Z. Hanley, Brian S. Robinson, Eric A. Ortlund, Rheinallt M. Jones, Andrew S. Neish   +12 more
doaj   +1 more source

ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53

mBio, 2019
Macrophages and dendritic cells dominate early immune responses to lentiviruses. HIV-1 sensing by pathogen recognition receptors induces signaling cascades that culminate in type I alpha/beta interferon (IFN-α/β) induction.
Edmund Osei Kuffour, Renate König, Dieter Häussinger, Wolfgang A. Schulz, Carsten Münk   +4 more
doaj   +1 more source

Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson’s Disease

Antioxidants, 2020
Hericium erinaceus, a valuable pharmaceutical and edible mushroom, contains potent bioactive compounds such as H. erinaceus mycelium (HEM) and its derived ethanol extraction of erinacine A, which have been found to regulate physiological functions in our
Kam-Fai Lee, Shui-Yi Tung, Chih-Chuan Teng, Chien-Heng Shen, Meng Chiao Hsieh, Cheng-Yi Huang, Ko-Chao Lee, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Wen-Shih Huang, Hsing-Chun Kuo   +11 more
doaj   +1 more source

Long noncoding RNA HOXC-AS3 interacts with CDK2 to promote proliferation in hepatocellular carcinoma

Biomarker Research, 2022
Background Hepatocellular carcinoma (HCC) is a type of cancer that affects the liver and has a high mortality rate. Long non-coding RNAs (lncRNAs) dysregulation can contribute to cancer occurrence and progression, although the underlying molecular ...
Chen Su, Weijian Wang, Jie Mo, Furong Liu, Hongwei Zhang, Yachong Liu, Xiaoping Chen, Zhibin Liao, Bixiang Zhang, Peng Zhu   +9 more
doaj   +1 more source

Osteopontin Regulates Ubiquitin-Dependent Degradation of Stat1 in Murine Mammary Epithelial Tumor Cells

Neoplasia: An International Journal for Oncology Research, 2007
Background: Osteopontin (OPN) is a secreted glycoprotein that mediates cell-matrix interactions and cellular signaling by binding with integrin (primarily αvβ3) and CD44 receptors.
Chengjiang Gao, Zhiyong Mi, Hongtao Guo, Paul C. Kuo   +3 more
doaj   +1 more source

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. [PDF]

, 2015
Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell ...
Cramer, Julie M, Dunn, James CY, Epperly, Michael, Greenberger, Joel, Judge, Colleen, Lagasse, Eric, Leibowitz, Brian J, Li, Linheng, Martin, Martin G, Stelzner, Matthias G, Wang, Fengchao, Wang, Xinwei, Wei, Liang, Yu, Jian, Zhang, Lin   +14 more
core   +2 more sources

p21 regulates the migration and polarization of macrophages in diabetic tooth extraction wound by regulating periodontal ligament fibroblasts

Kouqiang hemian waike zazhi
[Objective:] To explore the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21) in the healing process of tooth extraction wounds in diabetic mice and the effect on migration and polarization of macrophages.
ZHU Jiayu, YI Zimei, CHEN Siyi, DING Shuwen, YAN Jiayu, WU Junhua   +5 more
doaj   +1 more source

Prognostic value of plasmablastic morphology and p21, p53 and Cyclin D1 expression in myeloma cells: retrospective study of 122 patients with newly diagnosed multiple myeloma

Biotechnology & Biotechnological Equipment, 2021
Multiple myeloma (MM) is the most common bone marrow malignancy which is defined with bone marrow infiltration of more than 10% of terminally differentiated plasma cells sive myeloma cells.
Jurijs Nazarovs, Austra Breikša, Regīna Kleina, Sandra Lejniece, Jūlija Voicehovska, Georgi Momekov   +5 more
doaj   +1 more source

Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence [PDF]

The EMBO Journal, 2002
The cyclin-dependent kinase (CDK) inhibitor p21(Waf1/Cip1/Sdi1) was identified initially as a gene induced in senescent cells and itself has been shown to cause permanent growth arrest/senescence. Reactive oxygen species (ROS), a byproduct of oxidative processes, can also induce an irreversible growth arrest similar to senescence. Here we show that p21
Macip, S., Igarashi, M., Fang, L., Chen, A., Pan, Z. Q., Lee, S. W., Aaronson, S. A.   +6 more
openaire   +3 more sources