Results 11 to 20 of about 398,988 (295)

Repeated Administration of Cisplatin Transforms Kidney Fibroblasts through G2/M Arrest and Cellular Senescence

Cells, 2022
Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer, but it has nephrotoxic side effects leading to acute kidney injury and subsequently chronic kidney disease (CKD).
Jia-Bin Yu, Dong-Sun Lee, Babu J. Padanilam, Jinu Kim   +3 more
doaj   +1 more source

c-Myc/microRNA-17-92 Axis Phase-Dependently Regulates PTEN and p21 Expression via ceRNA during Reprogramming to Mouse Pluripotent Stem Cells

Biomedicines, 2023
Induced pluripotent stem cells (iPSCs) are promising cell sources for regenerative medicine and disease modeling. iPSCs are commonly established by introducing the defined reprogramming factors Oct4, Sox2, Klf4, and c-Myc.
Tomoaki Ishida, Tomoe Ueyama, Dai Ihara, Yukihiro Harada, Sae Nakagawa, Kaho Saito, Shu Nakao, Teruhisa Kawamura   +7 more
doaj   +1 more source

The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27

Frontiers in Cell and Developmental Biology, 2020
The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffolding
Carmen Rodriguez-Cupello, Monica Dam, Laura Serini, Shan Wang, David Lindgren, Emelie Englund, Pontus Kjellman, Håkan Axelson, Alberto García-Mariscal, Chris D. Madsen   +9 more
doaj   +1 more source

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]

, 2015
BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi, Bauer, Jessica, Carroll, Timothy, Eckmann, Lars, Grippo, Paul J, Jung, Barbara, Ozden, Ozkan, Principe, Daniel R, Spehlmann, Martina E, Staudacher, Jonas J   +9 more
core   +2 more sources

MDM2 Antagonists Counteract Drug-Induced DNA Damage

EBioMedicine, 2017
Antagonists of MDM2-p53 interaction are emerging anti-cancer drugs utilized in clinical trials for malignancies that rarely mutate p53, including melanoma. We discovered that MDM2-p53 antagonists protect DNA from drug-induced damage in melanoma cells and
Anna E. Vilgelm, Priscilla Cobb, Kiran Malikayil, David Flaherty, C. Andrew Johnson, Dayanidhi Raman, Nabil Saleh, Brian Higgins, Brandon A. Vara, Jeffrey N. Johnston, Douglas B. Johnson, Mark C. Kelley, Sheau-Chiann Chen, Gregory D. Ayers, Ann Richmond   +14 more
doaj   +1 more source

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21

FEBS Open Bio, 2022
Cholangiocarcinoma (CC) has a poor prognosis and different driver genes depending on the site of onset. Intrahepatic CC is the second‐most common liver cancer after hepatocellular carcinoma, and novel therapeutic targets are urgently needed.
Etsushi Kawamura, Tsutomu Matsubara, Atsuko Daikoku, Sanae Deguchi, Masahiko Kinoshita, Hideto Yuasa, Hayato Urushima, Naoshi Odagiri, Hiroyuki Motoyama, Kohei Kotani, Ritsuzo Kozuka, Atsushi Hagihara, Hideki Fujii, Sawako Uchida‐Kobayashi, Shogo Tanaka, Shigekazu Takemura, Keiko Iwaisako, Masaru Enomoto, Y. H. Taguchi, Akihiro Tamori, Shoji Kubo, Kazuo Ikeda, Norifumi Kawada   +22 more
doaj   +1 more source

Crude aqueous extracts of Pluchea indica (L.) Less. inhibit proliferation and migration of cancer cells through induction of p53-dependent cell death

BMC Complementary and Alternative Medicine, 2012
Background Pluchea indica (L.) Less. (Asteraceae) is a perennial shrub plant with anti-inflammatory and antioxidant medicinal properties. However, the anti-cancer properties of its aqueous extracts have not been studied.
Cho Jonathan J, Cho Chung-Lung, Kao Chiu-Li, Chen Chien-Ming, Tseng Chao-Neng, Lee Ya-Zhe, Liao Li-Jen, Hong Yi-Ren   +7 more
doaj   +1 more source

Involvement of miR-106b in tumorigenic actions of both prolactin and estradiol. [PDF]

, 2017
Prolactin promotes a variety of cancers by an array of different mechanisms. Here, we have investigated prolactin's inhibitory effect on expression of the cell cycle-regulating protein, p21.
Bustamante, Karissa, Chen, Kuan-Hui Ethan, Nguyen, Vi, Walker, Ameae M   +3 more
core   +1 more source

Synthetic Lethality of Chk1 Inhibition Combined with p53 and/or p21 Loss During a DNA Damage Response in Normal and Tumor Cells [PDF]

, 2013
Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by ...
A Besson, A Eastman, A Goga, A Goloudina, A Z Munir, AA Levesque, AA Levesque, AJ Fikaris, AN Tse, AT Ferguson, B Xu, C Tapia, CJ Sherr, CS Sorensen, CX Ma, EA Kohn, EA Kohn, F Bunz, FI Raynaud, H Piwnica-Worms, H Zhao, I Hassepass, J Bartkova, J Falck, K Shimuta, L S White, LL Parker, MH Lam, MV Cespedes, O Gilad, O Wang, OA Sedelnikova, PM Fracasso, R Di Micco, R Rodriguez, RP Perez, RT Bunch, S Origanti, S-r Cai, SD Zabludoff, T Abbas, T Waldman, WR Taylor, Y Luo   +43 more
core   +2 more sources