Results 1 to 10 of about 398,988 (295)

p21 in Cancer Research [PDF]

Cancers, 2019
p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models emphasized the role of this protein in cell cycle arrest under the p53 transcription factor activity.
Bahar Shamloo, Sinem Usluer
exaly   +3 more sources

An E2F1/DDX11/EZH2 Positive Feedback Loop Promotes Cell Proliferation in Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) accounts for one of the leading causes of cancer-related death, and is attributed to the dysregulation of genes involved in genome stability.
Shu-Guang Su, Qiu-Li Li, Mei-Fang Zhang, Peng-Wei Zhang, Huimin Shen, Chris Zhiyi Zhang   +5 more
doaj   +1 more source

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype [PDF]

PeerJ, 2013
The end replication problem, which occurs in normal somatic cells inducing replicative senescence, is solved in most cancer cells by activating telomerase.
Lei Zhao, Michael Wink
doaj   +2 more sources

Senescence of alveolar epithelial cells impacts initiation and chronic phases of murine fibrosing interstitial lung disease

Frontiers in Immunology, 2022
Fibrosing interstitial lung disease (ILD) develops due to the impaired reparative processes following lung tissue damage. Cellular senescence has been reported to contribute to the progression of fibrosis. However, the mechanisms by which these senescent
Zento Yamada, Zento Yamada, Junko Nishio, Junko Nishio, Kaori Motomura, Satoshi Mizutani, Soichi Yamada, Tetuo Mikami, Toshihiro Nanki, Toshihiro Nanki   +9 more
doaj   +1 more source

The m6A methyltransferase METTL16 inhibits the proliferation of pancreatic adenocarcinoma cancer cells via the p21 signaling pathway

Frontiers in Oncology, 2023
BackgroundMany studies have reported that N6-methyladenosine (m6A) modification plays a critical role in the epigenetic regulation of organisms and especially in the pathogenesis of malignant diseases.
Fuming Xie, Fuming Xie, Fuming Xie, Fuming Xie, Yao Zheng, Yao Zheng, Wen Fu, Wen Fu, Wen Fu, Wen Fu, Bojing Chi, Bojing Chi, Xianxing Wang, Xianxing Wang, Junfeng Zhang, Jianyou Gu, Jingyang Yin, Jingyang Yin, Jingyang Yin, Jingyang Yin, Qiang Zhou, Qiang Zhou, Shixiang Guo, Shixiang Guo, Lei Cai, Jiali Yang, Jiali Yang, Songsong Liu, Huaizhi Wang, Huaizhi Wang, Huaizhi Wang, Huaizhi Wang, Huaizhi Wang   +32 more
doaj   +1 more source

Constitutive cytoplasmic localization of p21Waf1/Cip1 affects the apoptotic process in monocytic leukaemia [PDF]

, 2003
In the present study, we analysed the expression and localization of p21Waf1/Cip1 in normal and malignant haematopoietic cells. We demonstrate that in normal monocytic cells, protein kinase C (PKC)-induced p21 gene activation, which is nuclear factor-κB (
A de Thonel, A Rambaldi, A Suzuki, A Suzuki, A Suzuki, A Suzuki, AS Baldwin Jr, CD Bloomfield, D Toullec, E Kobayashi, E Schreiber, H Ichijo, HY Chang, J Chen, J Chen, J Lin, JE Thompson, JJ Schuringa, JM Bennett, JM Herbert, JM Lai, K Kuno, K Kuno, KN Pennington, KU Birkenkamp, KU Birkenkamp, KU Birkenkamp, L Koenderman, L Rossig, LM Tuyt, M Asada, M Asada, M Mizuki, M Nakanishi, ML Guzman, MT Scott, MV Blagosklonny, MW Mayo, PJ Fialkow, RA Steinman, TS Finco, Y Arvidsson, Y Li, Y Luo, Y Miyazaki   +44 more
core   +9 more sources

CPEB4 Inhibit Cell Proliferation via Upregulating p21 mRNA Stability in Renal Cell Carcinoma

Frontiers in Cell and Developmental Biology, 2021
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) has been reported to be dysregulated in a variety of cancers and seems to play paradoxical roles in different cancers.
Jiehui Di, Jiehui Di, Jiehui Di, Hui Wang, Hui Wang, Hui Wang, Zhongjun Zhao, Zhongjun Zhao, Zhongjun Zhao, Guang Zhao, Guang Zhao, Guang Zhao, Xiaobing Qin, Zhengxiang Han, Yong Liu, Yong Liu, Yong Liu   +16 more
doaj   +1 more source

Role of P21 in Resistance of Lung Cancer

Chinese Journal of Lung Cancer, 2020
Lung cancer is the most common malignant tumor in the world with the highest incidence of deaths. In recent years, the treatment of lung cancer has made a significant breakthrough.
Tian FU, Ailing LIANG, Yongjun LIU
doaj   +1 more source

Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells

Frontiers in Oncology, 2020
Abnormal histone deacetylase (HDAC) expression is closely related to cancer development and progression. Many HDAC inhibitors have been widely used in cancer treatment; however, severe side effects often limit their clinical application.
Chi-Yuan Chen, Chi-Yuan Chen, Chin-Chuan Chen, Chin-Chuan Chen, Wen-Yu Chuang, Yann-Lii Leu, Yann-Lii Leu, Yann-Lii Leu, Shir-Hwa Ueng, Chuen Hsueh, Chuen Hsueh, Chau-Ting Yeh, Tong-Hong Wang, Tong-Hong Wang, Tong-Hong Wang   +14 more
doaj   +1 more source

CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma

Cancer Biology & Medicine, 2020
Objective: The E3 ligase, CRL4, plays diverse roles in different cellular processes, such as DNA damage, transcriptional regulation, cell cycle progression, and cell apoptosis.
Ting Li, Si Wu, Lei Jia, Wenfeng Cao, Yuan Yao, Gang Zhao, Hui Li   +6 more
doaj   +1 more source