Results 41 to 50 of about 46,904 (259)

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2014
About 15 years ago it was proposed that generation of the truncated protein p25 contributes to toxicity in Alzheimer's disease (AD). p25 is a calcium-dependent degradation product of p35, the principal activator of cyclin-dependent kinase 5 (Cdk5).
Karl Peter eGiese
doaj   +1 more source

Systematic Phosphorus‐Driven Structural and Field Engineering of n‐a‐Si:H for Flexible n‐a‐Si:H/Te Near‐Infrared Photodetectors

Advanced Science, EarlyView.
Our research elucidates the systematic evolution of the microstructure and optoelectronic properties of n‐a‐Si:H governed by the phosphine dilution ratio. Optimally phosphorus‐doped n‐a‐Si:H is integrated with Te to form a flexible heterojunction, enabling high‐performance near‐infrared photodetectors.
Kyeong‐jin Hyun, Soo‐Won Choi, Byeongjin Park, Hee‐Won Jang, Jongwon Yoon, Yonghun Kim, Woon Ik Park, Jung‐Dae Kwon   +7 more
wiley   +1 more source

Prenatal p25-activated Cdk5 induces pituitary tumorigenesis through MCM2 phosphorylation-mediated cell proliferation

Neoplasia: An International Journal for Oncology Research
Aberrant expression of cyclin-dependent kinase 5 (Cdk5) has been reported in pituitary adenomas. However, the role of Cdk5 in the tumorigenesis remains unclear. We show that prenatal p25-activated Cdk5 phosphorylates minichromosome maintenance protein 2 (
Yingwei Huang, Qiqi Wang, Weiwei Zhou, Yawei Jiang, Kai He, Wei Huang, Yating Feng, Hong Wu, Lijuan Liu, Yue Pan, Yihua Huang, Zirui Chen, Wei Li, Yaowei Huang, Guanchuan Lin, Yulong Zhang, Yongyan Ren, Kaibiao Xu, Yanlin Yu, Yuping Peng, Xinghua Pan, Suyue Pan, Hailiang Hu, Yafang Hu   +23 more
doaj   +1 more source

Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies

Neurobiology of Disease, 2004
The novel basic, heat-stable tubulin polymerization promoting protein TPPP/p25 is associated with microtubules in vitro and can induce the formation of aberrant microtubule assemblies.
Gábor G. Kovács, Lajos László, János Kovács, Poul Henning Jensen, Evo Lindersson, Gergő Botond, Tamás Molnár, András Perczel, Ferenc Hudecz, Gábor Mező, Anna Erdei, László Tirián, Attila Lehotzky, Ellen Gelpi, Herbert Budka, Judit Ovádi   +15 more
doaj   +1 more source

Gamma Radiation Synthesis of Ag/P25 Nanocomposites for Efficient Photocatalytic Degradation of Organic Contaminant

Nanomaterials, 2023
Titanium dioxide (TiO2) has garnered significant attention among various photocatalysts, whereas its photocatalytic activity is limited by its wide bandgap and inefficient charge separation, making the exploration of new strategies to improve its ...
Zihua Zeng, Shuangxiao Li, Xueyan Que, Jing Peng, Jiuqiang Li, Maolin Zhai   +5 more
doaj   +1 more source

t(3;8)(p25;q24) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019
Review on t(3;8)(p25;q24), with data on ...
openaire   +2 more sources

A Printed Hydrogel Hybrid Electronic System With Thermoresponsive Adhesion for Neurophysiological Monitoring

Advanced Science, EarlyView.
This work develops a soft hybrid electronic system with printed thermoresponsive hydrogel electrodes, which enables high‐fidelity neural signal acquisition and stimulation. The system precisely assesses median and ulnar nerve injuries in clinical cases, realizing accurate diagnosis of neural impairment while ensuring customized adhesion regulation ...
Bo Pang, Ganguang Yang, Jiacheng Wen, Hangyu Gong, Caixin Gong, Yuqi Qiu, Zhixin Wang, Qingyang Zheng, Sen Zhou, Tianzhao Bu, Jia Tian, Zhouping Yin, Yutian Liu, Hao Wu   +13 more
wiley   +1 more source

Comparative study of catalytic activity of N, S, N-S doping P25 on degradation of acid red B in visible light

Journal of Hebei University of Science and Technology, 2017
In order to improve the photocatalytic properties of P25, using urea, thiourea and methionine as modifiers, the modified catalysts N-P25, S-P25 and N,S-P25 with visible light catalytic activity are prepared by grinding-calcination method, respectively ...
Xiao LUO, Qin YANG, Yuechao SONG, Tongyao HAO, Lin YUE   +4 more
doaj   +1 more source

Enhancement of photocatalytic activity by Z-scheme heterojunction of CaTiO3 nanocuboids and P25

Energy Reports, 2023
Photocatalysis is an interesting approach to convert solar energy into chemical energy. To achieve efficient energy conversion, a mixed photocatalyst of CaTiO3 nanocuboids and commercial anatase TiO2 nanoparticles P25 were used.
Genki Saijo, Dang Trang Nguyen, Kozo Taguchi   +2 more
doaj   +1 more source