Results 11 to 20 of about 126,105 (250)

P27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability [PDF]

, 2015
The cyclin-dependent kinase (CDK) inhibitor p27(kip1) is a critical regulator of the G1/S-phase transition of the cell cycle and also regulates microtubule (MT) stability.
Armenia, Joshua, Baldassarre, Gustavo, Belletti, Barbara, Berton, Stefania, Bomben, Riccardo, D'Andrea, Sara, Fabris, Linda, Gattei, Valter, Pellizzari, Ilenia, Philips, Mark R., Schiappacassi, Monica, Segatto, Ilenia, VECCHIONE, ANDREA   +12 more
core   +1 more source

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine.

PLoS Biology, 2018
We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on
Niloofar Ale-Agha, Christine Goy, Philipp Jakobs, Ioakim Spyridopoulos, Stefanie Gonnissen, Nadine Dyballa-Rukes, Karin Aufenvenne, Florian von Ameln, Mark Zurek, Tim Spannbrucker, Olaf Eckermann, Sascha Jakob, Simone Gorressen, Marcel Abrams, Maria Grandoch, Jens W Fischer, Karl Köhrer, René Deenen, Klaus Unfried, Joachim Altschmied, Judith Haendeler   +20 more
doaj   +1 more source

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

Scientific Reports, 2023
p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs.
Rhianna J. Rowland, Richard Heath, Daniel Maskell, Rebecca F. Thompson, Neil A. Ranson, James N. Blaza, Jane A. Endicott, Martin E. M. Noble, Marco Salamina   +8 more
doaj   +1 more source

Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma [PDF]

, 2013
BACKGROUND: The cyclin-dependent kinase inhibitor p27(Kip1) functions during normal cerebellar development and has demonstrated tumor suppressor functions in mouse models of medulloblastoma. Because P27 loss is associated with increased proliferation, we
Amar Gajjar, Beryl A Hatton, David W Ellison, James M Olson, Marcel Kool, Matthew Fero   +5 more
core   +2 more sources

FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia

Haematologica, 2017
P27Kip1 (p27) can prevent cell proliferation by inactivating cyclin-dependent kinases. This function is impaired upon phosphorylation of p27 at tyrosine residue 88. We observed that FLT3 and FLT3-ITD can directly bind and selectively phosphorylate p27 on
Ines Peschel, Silvio R. Podmirseg, Martin Taschler, Justus Duyster, Katharina S. Götze, Heinz Sill, David Nachbaur, Heidelinde Jäkel, Ludger Hengst   +8 more
doaj   +1 more source

Enhanced ribosomal association of p27Kip1 mRNA is a mechanism contributing to accumulation during growth arrest [PDF]

, 1997
p27(Kip1) regulates the decision to enter into S-phase or withdraw from the cell cycle by establishing an inhibitory threshold above which G(1) cyclin-dependent kinases accumulate before activation. We have used the HL-60 cell line to study regulation of
Kiyokawa, Hiroaki, Koff, Andrew, Millard, S. Sean, Nguyen, Hoang, Pagano, Michele, Yan, Jie Shi   +5 more
core   +1 more source

p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

eLife, 2017
p27Kip1 (p27) is a cyclin-CDK inhibitor and negative regulator of cell proliferation. p27 also controls other cellular processes including migration and cytoplasmic p27 can act as an oncogene. Furthermore, cytoplasmic p27 promotes invasion and metastasis,
Pauline Jeannot, Ada Nowosad, Renaud T Perchey, Caroline Callot, Evangeline Bennana, Takanori Katsube, Patrick Mayeux, François Guillonneau, Stéphane Manenti, Arnaud Besson   +9 more
doaj   +1 more source

The growth suppressor p27Kip1 protects against diet-induced atherosclerosis [PDF]

, 2001
7 páginas, 5 figuras.The molecular basis of atherosclerosis is associated with excessive proliferation of vascular cells. Previous studies have suggested an inverse correlation between the expression of the growth suppressor p27Kip1 (p27) and cellular ...
Andrés, Vicente, Díez-Juan, Antonio
core   +1 more source

PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation

Journal of Experimental & Clinical Cancer Research, 2018
Background Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis ...
Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang   +12 more
doaj   +1 more source

p27^Kip1 deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process

BMC Cancer, 2010
Background p27 is a cell cycle suppressor gene, whose protein is a negative regulator of cyclin/cdk complexes. p27 is also a potential target of retinoids in cancer prevention studies. In benign prostate hyperplasia (BPH), and in most carcinomas, p27Kip1
Kiyokawa Hiroaki, Green Albert, Shilkaitis Anne, Stoynev Nikolay, Ke Hengning, Ali Arshia, Mathias Amanda, Taylor Winna, Christov Konstantin   +8 more
doaj   +1 more source