Results 1 to 10 of about 204,217 (208)

Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review

Brain Research Bulletin, 2023
Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
doaj   +2 more sources

P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells [PDF]

Biomolecules, 2022
Extracellular ATP (eATP) and P2 receptors are novel emerging regulators of T-lymphocyte responses. Cellular ATP is released via multiple pathways and accumulates at sites of tissue damage and inflammation. P2 receptor expression and function are affected
Valentina Vultaggio-Poma, Francesco Di Virgilio   +1 more
doaj   +2 more sources

Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation [PDF]

Frontiers in Pharmacology, 2019
Organs and tissues and their constituent cells are physiologically submitted to diverse types of mechanical forces or stress, one common sequence of which is release of intracellular ATP into extracellular space.
Linyu Wei, Fatema Mousawi, Dongliang Li, Sébastien Roger, Jing Li, Xuebin Yang, Lin-Hua Jiang, Lin-Hua Jiang, Lin-Hua Jiang   +8 more
doaj   +2 more sources

Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis. [PDF]

Int J Mol Sci, 2020
Christensen MG, Johnsen N, Skals M, Hamilton ADM, Rubak P, Hvas AM, Praetorius H.   +6 more
europepmc   +3 more sources

Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling. [PDF]

Stem Cells, 2020
Mousawi F, Peng H, Li J, Ponnambalam S, Roger S, Zhao H, Yang X, Jiang LH.   +7 more
europepmc   +3 more sources

A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model. [PDF]

Front Cell Neurosci, 2018
Sun H, Ma L, Zhang Y, Pan X, Wang C, Zhang J, Zhang X, Sun H, Wang Q, Zhu W.   +9 more
europepmc   +3 more sources

Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

Frontiers in Pharmacology, 2021
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

Role of Nucleotide P2 Receptors in the Immune System: Focus on Effector T Cells. [PDF]

Cells
Babou Kammoe RB, Hamoudi C, Aoudjit F.
europepmc   +3 more sources

Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies

Journal of Pharmacological Sciences, 2022
Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been extensively studied in pain signaling.
Kazuhide Inoue
doaj   +1 more source

Activation of P2×7 Receptor Promotes the Invasion and Migration of Colon Cancer Cells via the STAT3 Signaling

Frontiers in Cell and Developmental Biology, 2020
The pathological mechanism of colon cancer is very complicated. Therefore, exploring the molecular basis of the pathogenesis of colon cancer and finding a new therapeutic target has become an urgent problem to be solved in the treatment of colon cancer ...
Wen-jun Zhang, Ce-gui Hu, Hong-liang Luo, Zheng-ming Zhu   +3 more
doaj   +1 more source