Results 91 to 100 of about 204,366 (349)

Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release [PDF]

, 2017
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in ...
Arnett, T R, Gueneri, D, Hajjawai, M O, Orriss, I R, Patel, J J, Shaw, K   +5 more
core   +2 more sources

Composition and Resulting Band Alignment at the TiO2/InP Heterointerface: A Fundamental Study Combining Photoemission Spectroscopy and Theory

Advanced Functional Materials, EarlyView.
The chemical composition and band alignment are systematically investigated at the TiO2/InP heterointerface. Thin TiO2 films are deposited by ALD on atomically ordered, P‐terminated p‐InP(100). By combining UPS, XPS, and ab initio molecular dynamics, the atomistic structure and electronic alignment are revealed.
Mohammad Amin Zare Pour, Muhammad Nawaz Qaisrani, Christian Höhn, Johannes Laurenz Wolf, Negin Mogharehabed, Jennifer Velazquez Rojas, Wolfram Jaegermann, Erich Runge, Roel van de Krol, Thomas Hannappel, Christian Dreßler, Agnieszka Paszuk   +11 more
wiley   +1 more source

Improving epilepsy management by targeting P2 × 7 receptor with ROS/electric responsive nanomicelles

Journal of Nanobiotechnology
Background The intricate pathogenesis of epilepsy, characterized by abnormal neuronal discharges and neuroinflammation, underscores the critical involvement of the adenosine triphosphate (ATP)-P2X purinoceptor 7 (P2 × 7) receptor pathway in inflammation ...
Zhaohong Kong, Jian Jiang, Min Deng, Ming Deng, Huisheng Wu   +4 more
doaj   +1 more source

Adsorption-desorption noise can be used for improving selectivity

, 2002
Small chemical sensors are subjected to adsorption-desorption fluctuations which usually considered as noise contaminating useful signal. Based on temporal properties of this noise, it is shown that it can be made useful if proper processed.
Vidybida, Alexander K.
core   +1 more source

Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]

, 2004
Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Peptide P2 targeting Vibrio parahaemolyticus PirB toxins blocks the cytotoxic effects to shrimp Litopenaeus vannamei

Aquaculture Reports
PirB is the main virulence factor of acute hepatopancreatic necrosis disease (AHPND) which induced the sloughing of hepatopancreatic cells and shrimp death.
Xin Zhang, Ting Chen, Chunhua Ren, Yanhong Wang, Xiao Jiang, Jiasheng Huang, Bo Ma, Boxiang Zhu, Jiayue Yin, Chaoqun Hu, Peng Luo   +10 more
doaj   +1 more source

In vitro and in vivo evaluation of a (18)F-labeled high affinity NOTA conjugated bombesin antagonist as a PET ligand for GRPR-targeted tumor imaging. [PDF]

PLoS ONE, 2013
Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this receptor can be used as a potential molecular target to visualize and treat these tumors.
Zohreh Varasteh, Ola Aberg, Irina Velikyan, Gunnar Lindeberg, Jens Sörensen, Mats Larhed, Gunnar Antoni, Mattias Sandström, Vladimir Tolmachev, Anna Orlova   +9 more
doaj   +1 more source

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer [PDF]

, 2015
In the absence of extracellular stimulation the adaptor protein growth factor receptor-bound protein (Grb2) and the phospholipase Plcγ1 compete for the same binding site on fibroblast growth factor receptor 2 (FGFR2).
A B Gladden, A Casamayor, A K Sood, AB Turke, AK Mahbub Hasan, B Rotblat, B Vanhaesebroeck, C Cole, C Gauglhofer, C Ivan, C V Kingsley, C Vallien, C-C Lin, DA Altomare, DA Altomare, EF Rodriguez, F Janku, G B Mills, G Lopez-Berestein, G N A Pena, I Vivanco, J Berrout, J Clark, J E Ladbury, J F Hancock, J Liu, J Pan, JA Engelman, JK Ching, K Yang, KH Khan, LM Ooms, M Bogdanov, M Cully, M Gagea, M Mazzoletti, M Ushio-Fukai, M-C Hung, MJ Fry, MS Song, MV Risbud, N Thapa, N Yamamoto, P Storz, R Troncoso, RB Campbell, RE Redfern, RW Tothill, S König, S Pirkmajer, S Srinivasan, SA Byron, TF Franke, X Hu, Y Katoh, Y Lu, Y Matsuda, Y Zhou, Y Zhou, Z Ahmed, Z Ahmed, Z Ahmed, Z Ahmed, Z Timsah, Z Timsah   +64 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source