Results 271 to 280 of about 92,291 (308)

P2-Pyrimidinergic Receptors and Their Ligands

Current Pharmaceutical Design, 2002
Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y(2), P2Y(4), P2Y(6) and P2Y(14).
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P2 receptors in the murine gastrointestinal tract

Neuropharmacology, 2002
The actions of adenosine, adenosine 5'-triphosphate (ATP), 2-methylthio adenosine diphosphate ADP (2-MeSADP), 2-methylthio ATP (2-MeSATP), alpha,beta-methylene ATP (alpha,beta-meATP) and uridine triphosphate (UTP) on isolated segments of mouse stomach (fundus), duodenum, ileum and colon were investigated. The localization of P2Y(1), P2Y(2), P2Y(4), P2X(
GIARONI, CRISTINA, KNIGHT G. E., RUAN H. Z., GLASS R., BARDINI M., LECCHINI, SERGIO, FRIGO, GIANMARIO, BURNSTOCK G.   +7 more
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The platelet P2 receptors in inflammation

Hämostaseologie, 2015
SummaryIn addition to their well characterized and established role in haemostasis and thrombosis, platelets contribute to the pathogenesis of inflammation. Adenine nucleotides are signalling molecules that regulate the function of virtually every cell in the body, by interacting with P2 receptors.
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Adventures in the pharmacological analysis of P2 receptors

Journal of the Autonomic Nervous System, 2000
The pharmacological classification of P2 receptors owes its origin to the pioneering efforts of Geoff Burnstock and those who followed him, research that was conducted primarily in physiological experimental systems. Over recent years, the techniques of molecular biology have been increasingly applied in the study of P2 receptors while, at the same ...
Fagura, M.S., Jarvis, Gavin, Dougall, I.G., Leff, P.   +3 more
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The platelet P2 receptors in arterial thrombosis

Blood Cells, Molecules, and Diseases, 2006
ADP and ATP play a crucial role in hemostasis and thrombosis and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X1 and the two G protein-coupled P2Y1 and P2Y12 ADP receptors selectively contribute to platelet aggregation.
Christian, Gachet, Catherine, Léon, Béatrice, Hechler   +2 more
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Salivary Gland P2 Nucleotide Receptors

Critical Reviews in Oral Biology & Medicine, 1999
The effects of ATP on salivary glands have been recognized since 1982. Functional and pharmacological studies of the P2 nucleotide receptors that mediate the effects of ATP and other extracellular nucleotides have been supported by the cloning of receptor cDNAs, by the expression of the receptor proteins, and by the identification in salivary gland ...
J T, Turner, L A, Landon, S J, Gibbons, B R, Talamo   +3 more
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P2 receptors meet the immune system

Trends in Pharmacological Sciences, 2001
Abstract The 1st International Workshop on Nucleotides and their Receptors in the Immune System was held on 8–10 September 2000 at the University of Ferrara, Ferrara, Italy.
DI VIRGILIO, Francesco, BOREA, Pier Andrea, ILLES P.   +2 more
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P2 Purinergic Receptors in Tumor Immunity

Cancer Research
Abstract P2 purinergic receptors are activated by extracellular ATP and other nucleotides released during cellular stress, hypoxia, or inflammation, serving as key mediators of intercellular communication. In cancer, they rapidly accumulate in the tumor microenvironment following cell death or metabolic stress.
Xin Wang, Shu-Heng Jiang, Mingyue Ma, Shuqi Cai, Dong Song, Bing Han   +5 more
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REGULATION OF PLATELET FUNCTIONS BY P2 RECEPTORS

Annual Review of Pharmacology and Toxicology, 2006
▪ Abstract  The main role of blood platelets is to ensure primary hemostasis, which is the maintenance of vessel integrity and cessation of bleeding upon injury. While playing a major part in acute arterial thrombosis, platelets are also involved in inflammation, atherosclerosis, and angiogenesis. ADP and ATP play a crucial role in platelet activation,
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The P2 Nucleotide Receptors

1998
Part I. Historical Perspectives of P2 Nucleotide Receptors. History of Extracellular Nucleotides and Their Receptors, G. Burnstock. Part II. Pharmacological and Molecular Characterization of P2 Nucleotide Receptors. P2x Receptors: Cloned and Expressed, R. J. Evans, A. Surprenant, and R. A. North.
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